Search Results - "Coló, Georgina P"

The MRL proteins: Adapting cell adhesion, migration and growth by Coló, Georgina P., Lafuente, Esther M., Teixidó, Joaquin

“…MIG-10, RIAM and Lamellipodin (Lpd) are the founding members of the MRL family of multi-adaptor molecules. These proteins have common domain structures but…”
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Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway by Coló, Georgina P, Hernández-Varas, Pablo, Lock, John, Bartolomé, Rubén A, Arellano-Sánchez, Nohemí, Strömblad, Staffan, Teixidó, Joaquin

“…Cell migration and invasion require regulated turnover of integrin-dependent adhesion complexes. Rap1-GTP-interacting adaptor molecule (RIAM) is an adaptor…”
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Hemoxygenase-1 Promotes Head and Neck Cancer Cell Viability by Mascaró, Marilina, Alonso, Exequiel G, Schweitzer, Karen, Rabassa, Martín E, Carballido, Jessica A, Ibarra, Agustina, Alonso, Eliana N, Bermúdez, Vicente, Fernández Chavez, Lucía, Coló, Georgina P, Ferronato, María Julia, Pichel, Pamela, Recio, Sergio, Clemente, Valentina, Fermento, Maria Eugenia, Facchinetti, María Marta, Curino, Alejandro C

“…Head and neck squamous cell carcinoma (HNSCC) is a remarkably heterogeneous disease with around 50% mortality, a fact that has prompted researchers to try new…”
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Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells by Hernández-Varas, Pablo, Coló, Georgina P., Bartolomé, Ruben A., Paterson, Andrew, Medraño-Fernández, Iria, Arellano-Sánchez, Nohemí, Cabañas, Carlos, Sánchez-Mateos, Paloma, Lafuente, Esther M., Boussiotis, Vassiliki A., Strömblad, Staffan, Teixidó, Joaquin

“…The Mig-10/RIAM/lamellipodin (MRL) family member Rap1-GTP-interacting adaptor molecule (RIAM) interacts with active Rap1, a small GTPase that is frequently…”
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Lfc subcellular localization and activity is controlled by αv-class integrin by Coló, Georgina P, Seiwert, Andrea, Haga, Raquel B

“…Fibronectin (FN)-binding integrins control a variety of cellular responses through Rho GTPases. The FN-binding integrins, αvβ3 and α5β1, are known to induce…”
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αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin by Bharadwaj, Mitasha, Strohmeyer, Nico, Colo, Georgina P., Helenius, Jonne, Beerenwinkel, Niko, Schiller, Herbert B., Fässler, Reinhard, Müller, Daniel J.

“…Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins trigger the recruitment of large protein assemblies and strengthen…”
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Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator by Cerikan, Berati, Shaheen, Ranad, Colo, Georgina P., Gläßer, Christine, Hata, Shoji, Knobeloch, Klaus-Peter, Alkuraya, Fowzan S., Fässler, Reinhard, Schiebel, Elmar

“…Genome-editing technologies allow systematic inactivation of human genes. Whether knockout phenotypes always reflect gene functions as determined by acute RNAi…”
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A Blk–p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion by Bartolomé, Rubén A., Díaz-Martínez, Marta, Coló, Georgina P., Arellano-Sánchez, Nohemí, Torres-Ayuso, Pedro, Kleinovink, Jan Willem, Mérida, Isabel, Teixidó, Joaquin

“…Activation of the GTPase RhoA linked to cell invasion can be tightly regulated following Gα13 stimulation. We have used a cellular model displaying…”
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Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA by Molina-Ortiz, Isabel, Bartolomé, Rubén A., Hernández-Varas, Pablo, Colo, Georgina P., Teixidó, Joaquin

“…Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the…”
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The dioxin receptor controls β1 integrin activation in fibroblasts through a Cbp–Csk–Src pathway by Rey-Barroso, Javier, Colo, Georgina P., Alvarez-Barrientos, Alberto, Redondo-Muñoz, Javier, Carvajal-González, José M., Mulero-Navarro, Sonia, García-Pardo, Angeles, Teixidó, Joaquín, Fernandez-Salguero, Pedro M.

“…Recent studies have suggested a regulatory role for the dioxin receptor (AhR) in cell adhesion and migration. Following our previous work, we report here that…”
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Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion by Hermann, Michaela-Rosemarie, Jakobson, Madis, Colo, Georgina P, Rognoni, Emanuel, Jakobson, Maili, Kupatt, Christian, Posern, Guido, Fässler, Reinhard

“…Integrin-mediated activation of small GTPases induces the polymerisation of G-actin into various actin structures and the release of the transcriptional…”
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Cyclin D1 is a NF-κB corepressor by Rubio, María F., Fernandez, Pablo N. Larrosa, Alvarado, Cecilia V., Panelo, L.C., Grecco, Marina Ruiz, Colo, Georgina P., Martínez-Noel, Giselle A., Micenmacher, Sabrina M., Costas, Mónica A.

“…NF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated…”
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RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis by Colo, Georgina P., Rosato, Roberto R., Grant, Steven, Costas, Mónica A.

“…The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human…”
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RAC3 nuclear receptor co-activator has a protective role in the apoptosis induced by different stimuli by Coló, Georgina P, Rubio, María F, Alvarado, Cecilia V, Costas, Mónica A

“…RAC3 belongs to the family of p160 nuclear receptors coactivators and it is over-expressed in several tumors. We have previously shown that RAC3 is a NF-kappaB…”
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The dioxin receptor controls beta 1 integrin activation in fibroblasts through a Cbp-Csk-Src pathway by Rey-Barroso, Javier, Colo, Georgina P, Alvarez-Barrientos, Alberto, Redondo-Munoz, Javier, Carvajal-Gonzalez, Jose M, Mulero-Navarro, Sonia, Garcia-Pardo, Angeles, Teixido, Joaquin, Fernandez-Salguero, Pedro M

“…Recent studies have suggested a regulatory role for the dioxin receptor (AhR) in cell adhesion and migration. Following our previous work, we report here that…”
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[alpha]V-class integrins exert dual roles on [alpha]5[beta]1 integrins to strengthen adhesion to fibronectin by Bharadwaj, Mitasha, Strohmeyer, Nico, Colo, Georgina P, Helenius, Jonne, Beerenwinkel, Niko, Schiller, Herbert B, Fässler, Reinhard, Müller, Daniel J

“…Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins trigger the recruitment of large protein assemblies and strengthen…”
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Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoAS by Molina-Ortiz, Isabel, Bartolomé, Rubén A., Hernández-Varas, Pablo, Colo, Georgina P., Teixidó, Joaquin

“…Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the…”
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Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kappaB transactivation by Nojek, Ignacio M, Werbajh, Santiago E, Colo, Georgina P, Rubio, Fernanda M, Franco, Lorena D, Nahmod, Victor E, Costas, Monica A

“…We have previously shown that nuclear receptor coactivator overexpression significantly enhanced NF-kappaB activity in a dose response manner. We studied the…”
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