Search Results - "Col, Valentina Dal"

Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing by Chen, Chao, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Laurini, Erik, Zhou, Jiehua, Liu, Cheng, Wang, Yang, Tang, Jingjie, Col, Valentina Dal, Yu, Tianzhu, Giorgio, Suzanne, Fermeglia, Maurizio, Qu, Fanqi, Liang, Zicai, Rossi, John J., Liu, Minghua, Rocchi, Palma, Pricl, Sabrina, Peng, Ling

“…Self‐assembly is a fundamental concept and a powerful approach in molecular science. However, creating functional materials with the desired properties through…”
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Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma by Pricl, Sabrina, Cortelazzi, Barbara, Dal Col, Valentina, Marson, Domenico, Laurini, Erik, Fermeglia, Maurizio, Licitra, Lisa, Pilotti, Silvana, Bossi, Paolo, Perrone, Federica

“…Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss-of-function mutations in the tumor suppressor gene, PTCH1. PTCH1…”
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Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC-33 Compounds: Promising Neuroprotective Agents Acting as σ1 Receptor Agonists by Rossi, Daniela, Pedrali, Alice, Gaggeri, Raffaella, Marra, Annamaria, Pignataro, Luca, Laurini, Erik, Dal Col, Valentina, Fermeglia, Maurizio, Pricl, Sabrina, Schepmann, Dirk, Wünsch, Bernhard, Peviani, Marco, Curti, Daniela, Collina, Simona

“…Our recent research efforts identified racemic RC‐33 as a potent and metabolically stable σ1 receptor agonist. Herein we describe the isolation of pure RC‐33…”
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Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib by Conca, Elena, Miranda, Claudia, Col, Valentina Dal, Fumagalli, Elena, Pelosi, Giuseppe, Mazzoni, Mara, Fermeglia, Maurizio, Laurini, Erik, Pierotti, Marco A., Pilotti, Silvana, Greco, Angela, Pricl, Sabrina, Tamborini, Elena

“…Gastrointestinal stromal tumors carry in about 85% of the cases activating mutations in KIT gene. Generally only one KIT mutation is found in primary tumors…”
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Another Brick in the Wall. Validation of the σ1 Receptor 3D Model by Computer-Assisted Design, Synthesis, and Activity of New σ1 Ligands by Laurini, Erik, Marson, Domenico, Dal Col, Valentina, Fermeglia, Maurizio, Mamolo, Maria Grazia, Zampieri, Daniele, Vio, Luciano, Pricl, Sabrina

“…Originally considered an enigmatic polypeptide, the σ1 receptor has recently been identified as a unique ligand-regulated protein. Many studies have shown the…”
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Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor by Laurini, Erik, Col, Valentina Dal, Mamolo, Maria Grazia, Zampieri, Daniele, Posocco, Paola, Fermeglia, Maurizio, Vio, Luciano, Pricl, Sabrina

“…This study presents for the first time the 3D model of the σ1 receptor protein as obtained from homology modeling techniques, shows the applicability of this…”
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Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 Receptor by Meyer, Christina, Schepmann, Dirk, Yanagisawa, Shuichi, Yamaguchi, Junichiro, Dal Col, Valentina, Laurini, Erik, Itami, Kenichiro, Pricl, Sabrina, Wünsch, Bernhard

“…To explore the hydrophobic binding region of the σ1 receptor protein, regioisomeric spirocyclic thiophenes 9–11 were developed as versatile building blocks…”
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Homology Model and Docking-Based Virtual Screening for Ligands of the σ 1 Receptor by Laurini, Erik, Col, Valentina Dal, Mamolo, Maria Grazia, Zampieri, Daniele, Posocco, Paola, Fermeglia, Maurizio, Vio, Luciano, Pricl, Sabrina

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Synthesis, Pharmacological Evaluation, and σ1 Receptor Interaction Analysis of Hydroxyethyl Substituted Piperazines by Weber, Frauke, Brune, Stefanie, Korpis, Katharina, Bednarski, Patrick J, Laurini, Erik, Dal Col, Valentina, Pricl, Sabrina, Schepmann, Dirk, Wünsch, Bernhard

“…Starting from (S)- or (R)-aspartate, three synthetic strategies were explored to prepare hydroxyethyl substituted piperazines with different substituents at…”
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Synthesis, Pharmacological Evaluation, and σ 1 Receptor Interaction Analysis of Hydroxyethyl Substituted Piperazines by Weber, Frauke, Brune, Stefanie, Korpis, Katharina, Bednarski, Patrick J., Laurini, Erik, Dal Col, Valentina, Pricl, Sabrina, Schepmann, Dirk, Wünsch, Bernhard

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siRNA Delivery: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016) by Chen, Chao, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Laurini, Erik, Zhou, Jiehua, Liu, Cheng, Wang, Yang, Tang, Jingjie, Col, Valentina Dal, Yu, Tianzhu, Giorgio, Suzanne, Fermeglia, Maurizio, Qu, Fanqi, Liang, Zicai, Rossi, John J., Liu, Minghua, Rocchi, Palma, Pricl, Sabrina, Peng, Ling

“…Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high‐generation dendrimers for siRNA delivery, as…”
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Abstract PR05: Resistance to Hedgehog inhibitor through Smoothened receptor mutation in basal cell carcinoma by Bossi, Paolo, Perrone, Federica, Cortellazzi, Barbara, Licitra, Lisa, Dal Col, Valentina, Laurini, Erik, Fermeglia, Maurizio, Pricl, Sabrina

“…Abstract The inappropriate activation of Hedgehog (Hh) pathway is involved in the pathogenesis of skin basal cell carcinoma (BCC). Loss of function of the…”
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Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ 1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ 1 Receptor by Meyer, Christina, Schepmann, Dirk, Yanagisawa, Shuichi, Yamaguchi, Junichiro, Dal Col, Valentina, Laurini, Erik, Itami, Kenichiro, Pricl, Sabrina, Wünsch, Bernhard

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Another Brick in the Wall. Validation of the σ 1 Receptor 3D Model by Computer-Assisted Design, Synthesis, and Activity of New σ 1 Ligands by Laurini, Erik, Marson, Domenico, Dal Col, Valentina, Fermeglia, Maurizio, Mamolo, Maria Grazia, Zampieri, Daniele, Vio, Luciano, Pricl, Sabrina

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2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria by Liu, Xinjun, Chen, Han, Laurini, Erik, Wang, Yang, Dal Col, Valentina, Posocco, Paola, Ziarelli, Fabio, Fermeglia, Maurizio, Zhang, Cheng-Cai, Pricl, Sabrina, Peng, Ling

“…2-Difluoromethylene-4-methylenepentanoic acid (DFMPA), a seemingly deviated analog of 2-oxoglutaric acid (2-OG), could surprisingly mimic its signaling…”
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Target sequencing approach intended to discover new mutations in non-syndromic intellectual disability by Morgan, Anna, Gandin, Ilaria, Belcaro, Chiara, Palumbo, Pietro, Palumbo, Orazio, Biamino, Elisa, Dal Col, Valentina, Laurini, Erik, Pricl, Sabrina, Bosco, Paolo, Carella, Massimo, Ferrero, Giovanni Battista, Romano, Corrado, d'Adamo, Adamo Pio, Faletra, Flavio, Vozzi, Diego

“…The technological improvements over the last years made considerable progresses in the knowledge of the etiology of intellectual Disability (ID). However, at…”
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Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC‐33 Compounds: Promising Neuroprotective Agents Acting as σ 1 Receptor Agonists by Rossi, Daniela, Pedrali, Alice, Gaggeri, Raffaella, Marra, Annamaria, Pignataro, Luca, Laurini, Erik, Dal Col, Valentina, Fermeglia, Maurizio, Pricl, Sabrina, Schepmann, Dirk, Wünsch, Bernhard, Peviani, Marco, Curti, Daniela, Collina, Simona

“…Abstract Our recent research efforts identified racemic RC‐33 as a potent and metabolically stable σ 1 receptor agonist. Herein we describe the isolation of…”
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siRNA Delivery: Mastering Dendrimer Self‐Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016) by Chen, Chao, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Laurini, Erik, Zhou, Jiehua, Liu, Cheng, Wang, Yang, Tang, Jingjie, Col, Valentina Dal, Yu, Tianzhu, Giorgio, Suzanne, Fermeglia, Maurizio, Qu, Fanqi, Liang, Zicai, Rossi, John J., Liu, Minghua, Rocchi, Palma, Pricl, Sabrina, Peng, Ling

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