Search Results - "Cojutti, Piergiorgio"

Dosing Nomograms for Attaining Optimum Concentrations of Meropenem by Continuous Infusion in Critically Ill Patients with Severe Gram-Negative Infections: a Pharmacokinetics/Pharmacodynamics-Based Approach by PEA, Federico, VIALE, Pierluigi, COJUTTI, Piergiorgio, FURLANUT, Mario

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Population Pharmacokinetics and Dosing Considerations for the Use of Linezolid in Overweight and Obese Adult Patients by Cojutti, Piergiorgio, Pai, Manjunath P., Pea, Federico

“…Background Linezolid is an anti-Gram-positive antimicrobial agent used at a fixed dose of 600 mg every 12 h. Objectives The objective of this study was to…”
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Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae by Cojutti, Piergiorgio, Sartor, Assunta, Righi, Elda, Scarparo, Claudio, Bassetti, Matteo, Pea, Federico

“…We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with carbapenemase (KPC)-producing…”
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Therapeutic Drug Monitoring of Linezolid: a Retrospective Monocentric Analysis by PEA, Federico, FURLANUT, Mario, COJUTTI, Piergiorgio, CRISTINI, Francesco, ZAMPARINI, Eleonora, FRANCESCHI, Loretta, VIALE, Pierluigi

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Antifungal Prophylaxis with Posaconazole in Patients with Acute Myeloid Leukemia: Dose Intensification Coupled with Avoidance of Proton Pump Inhibitors Is Beneficial in Shortening Time to Effective Concentrations by COJUTTI, Piergiorgio, CANDONI, Anna, SIMEONE, Erica, FRANCESCHI, Loretta, FANIN, Renato, PEA, Federico

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Successful Long-Term Treatment of Cerebral Nocardiosis with Unexpectedly Low Doses of Linezolid in an Immunocompromised Patient Receiving Complex Polytherapy by Pea, Federico, Cojutti, Piergiorgio, Pagotto, Alberto, Cristini, Francesco, Furlanut, Mario, Viale, Pierluigi

“…Cerebral nocardiosis is a severe infection that carries the highest mortality rate among all bacterial cerebral abscesses. We report on a case in an…”
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Monitoring Polypharmacy in Healthcare Systems through a Multi-Setting Survey: Should We Put More Attention on Long Term Care Facilities? by Arnoldo, Luca, Cattani, Giovanni, Cojutti, Piergiorgio, Pea, Federico, Brusaferro, Silvio

“…Background Polypharmacy is a main issue of patient safety in all healthcare settings (i.e. increase adverse drug reactions and incidence of drug-drug…”
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Pharmacokinetic Interaction Between Everolimus and Antifungal Triazoles in a Liver Transplant Patient by Pea, Federico, Baccarani, Umberto, Tavio, Marcello, Cojutti, Piergiorgio, Adani, Gian Luigi, Londero, Angela, Baraldo, Massimo, Franceschi, Loretta, Furlanut, Mario, Viale, Pierluigi

“…Objective: TO describe the management of a pharmacokinetic interaction between azole antifungals (fluconazole and voriconazole) and everolimus in a patient who…”
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The pharmacokinetics of recombinant FXIII (catridecacog) from the MENTORTM2 trial to a real-world study: a head-to-head comparison by Pasca, Samantha, PierGiorgio, Cojutti, Pea, Federico

“…Background FXIII deficiency is a very rare coagulation disorder that can affect equally males and females with an estimated incidence of 1 in 2 million persons…”
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Pharmacokinetics and pharmacodynamics of continuous-infusion meropenem in pediatric hematopoietic stem cell transplant patients by Cojutti, Piergiorgio, Maximova, Natalia, Pea, Federico

“…This study explored the pharmacokinetics and the pharmacodynamics of continuous-infusion meropenem in a population of pediatric hematopoietic stem cell…”
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Might real-time pharmacokinetic/pharmacodynamic optimisation of high-dose continuous-infusion meropenem improve clinical cure in infections caused by KPC-producing Klebsiella pneumoniae ? by Pea, Federico, Della Siega, Paola, Cojutti, Piergiorgio, Sartor, Assunta, Crapis, Massimo, Scarparo, Claudio, Bassetti, Matteo

“…Highlights • PK/PD optimisation of meropenem can overcome resistance of MDR Gram-negative organisms. • Real-time clinical pharmacological advice is valuable in…”
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Correction to: The pharmacokinetics of recombinant FXIII (catridecacog) from the MENTORTM2 trial to a real-world study: a head-to-head comparison by Pasca, Samantha, Cojutti, PierGiorgio, Pea, Federico, Zanon, Ezio

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Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients by PEA, Federico, VIALE, Pierluigi, COJUTTI, Piergiorgio, DEL PIN, Barbara, ZAMPARINI, Eleonora, FURLANUT, Mario

“…Prolonged treatment with linezolid may cause toxicity. The purpose of this study was to define pharmacodynamic thresholds for improving safety outcomes of…”
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Pharmacokinetics and Pharmacodynamics of Continuous Infusion Meropenem in Overweight, Obese, and Morbidly Obese Patients with Stable and Unstable Kidney Function: A Step Toward Dose Optimization for the Treatment of Severe Gram-Negative Bacterial Infections by Pai, Manjunath P., Cojutti, Piergiorgio, Pea, Federico

“…Background Meropenem is an anti-Gram-negative antimicrobial, the time-dependent activity of which may be maximized through administration by continuous…”
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Polytherapy and the risk of potentially inappropriate prescriptions (PIPs) among elderly and very elderly patients in three different settings (hospital, community, long-term care facilities) of the Friuli Venezia Giulia region, Italy: are the very elderly at higher risk of PIPs? by Cojutti, Piergiorgio, Arnoldo, Luca, Cattani, Giovanni, Brusaferro, Silvio, Pea, Federico

“…Purpose The aim of this point‐prevalence study was to assess the occurrence of polypharmacy and hyperpolypharmacy and the risk of potentially inappropriate…”
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Limited sampling strategies for determining the area under the plasma concentration–time curve for isoniazid might be a valuable approach for optimizing treatment in adult patients with tuberculosis by Cojutti, Piergiorgio, Giangreco, Manuela, Isola, Miriam, Pea, Federico

“…Highlights • Isoniazid exposure following the standard dose may vary greatly between patients with tuberculosis. • Optimizing isoniazid exposure is becoming an…”
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Clinical and pharmacokinetic drug evaluation of delafloxacin for the treatment of acute bacterial skin and skin structure infections by Bassetti, Matteo, Pecori, Davide, Cojutti, Piergiorgio, Righi, Elda, Pea, Federico

“…In the era of multi-drug resistant pathogens, the adequate treatment of skin and skin structure infections remains a challenge for clinicians. Delafloxacin,…”
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A 1 year retrospective audit of quality indicators of clinical pharmacological advice for personalized linezolid dosing: one stone for two birds? by Pea, Federico, Cojutti, Piergiorgio, Dose, Lucia, Baraldo, Massimo

“…Aim This study explored the clinical and economic impact of clinical pharmacological advice (CPA) (based on therapeutic drug monitoring [TDM] results, and on…”
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Levofloxacin Dosing Regimen in Severely Morbidly Obese Patients (BMI ≥40 kg/m2) Should Be Guided by Creatinine Clearance Estimates Based on Ideal Body Weight and Optimized by Therapeutic Drug Monitoring by Pai, Manjunath P., Cojutti, Piergiorgio, Pea, Federico

“…Background Levofloxacin is a commonly prescribed antimicrobial where recommendations exist to reduce doses for renal impairment but not to increase doses for…”
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Stability of generic meropenem solutions for administration by continuous infusion at normal and elevated temperatures by Franceschi, Loretta, Cojutti, Piergiorgio, Baraldo, Massimo, Pea, Federico

“…Administration by continuous infusion may represent an effective tool for the treatment of multidrug-resistant gram-negative related infections with meropenem…”
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