Search Results - "Cohoon, Travis J."

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models by Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Hung, Kenneth E., Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.

“…KRAS is the most commonly mutated oncogene, yet no effective targeted therapies exist for KRAS mutant cancers. We developed a pooled shRNA-drug screen strategy…”
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Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non―Small Cell Lung Cancer by SHIMAMURA, Takeshi, ZHAO CHEN, AKBAY, Esra, KIMMELMAN, Alec C, KUNG, Andrew L, BRADNER, James E, WONG, Kwok-Kin, SOUCHERAY, Margaret, CARRETERO, Julian, KIKUCHI, Eiki, TCHAICHA, Jeremy H, YANDI GAO, CHENG, Katherine A, COHOON, Travis J, JUN QI

“…Amplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth, invasion, and…”
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Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth by Barbie, Thanh U, Alexe, Gabriela, Aref, Amir R, Li, Shunqiang, Zhu, Zehua, Zhang, Xiuli, Imamura, Yu, Thai, Tran C, Huang, Ying, Bowden, Michaela, Herndon, John, Cohoon, Travis J, Fleming, Timothy, Tamayo, Pablo, Mesirov, Jill P, Ogino, Shuji, Wong, Kwok-Kin, Ellis, Matthew J, Hahn, William C, Barbie, David A, Gillanders, William E

“…Triple-negative breast cancers (TNBCs) are a heterogeneous set of cancers that are defined by the absence of hormone receptor expression and HER2…”
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Multicenter validation of a machine learning phase space electro-mechanical pulse wave analysis to predict elevated left ventricular end diastolic pressure at the point-of-care by Bhavnani, Sanjeev P, Khedraki, Rola, Cohoon, Travis J, Meine, 3rd, Frederick J, Stuckey, Thomas D, McMinn, Thomas, Depta, Jeremiah P, Bennett, Brett, McGarry, Thomas, Carroll, William, Suh, David, Steuter, John A, Roberts, Michael, Gillins, Horace R, Shadforth, Ian, Lange, Emmanuel, Doomra, Abhinav, Firouzi, Mohammad, Fathieh, Farhad, Burton, Timothy, Khosousi, Ali, Ramchandani, Shyam, Sanders, Jr, William E, Smart, Frank

“…Phase space is a mechanical systems approach and large-scale data representation of an object in 3-dimensional space. Whether such techniques can be applied to…”
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Attempted Cardiopulmonary Bypass Venous Cannula Extraction Catheter Extraction of a Rare Intracardiac Myoepithelioma by Cohoon, Travis J, King, Matthew R, Gharai, Fariba, Abolhoda, Amir, Sakwa, Marc, Shavelle, David M

“…Myoepithelioma of the soft tissue is a rare entity that can mimic myxoma when presenting within the heart. We present a case where cardiopulmonary bypass…”
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Identifying novel phenotypes of elevated left ventricular end diastolic pressure using hierarchical clustering of features derived from electromechanical waveform data by Burton, Timothy, Ramchandani, Shyam, Bhavnani, Sanjeev P., Khedraki, Rola, Cohoon, Travis J., Stuckey, Thomas D., Steuter, John A., Meine, Frederick J., Bennett, Brett A., Carroll, William S., Lange, Emmanuel, Fathieh, Farhad, Khosousi, Ali, Rabbat, Mark, Sanders, William E.

“…Introduction Elevated left ventricular end diastolic pressure (LVEDP) is a consequence of compromised left ventricular compliance and an important measure of…”
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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors by Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin

“…The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We…”
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Extreme Angiographic-Physiologic Mismatch With Elevated Left Ventricular End-Diastolic Pressure by Cohoon, Travis J., Kern, Morton J.

“…Translesional coronary pressure measures the hemodynamic significance of epicardial coronary artery disease. Angiographic-physiologic mismatching is attributed…”
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Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit by Zhu, Zehua, Aref, Amir R, Cohoon, Travis J, Barbie, Thanh U, Imamura, Yu, Yang, Shenghong, Moody, Susan E, Shen, Rhine R, Schinzel, Anna C, Thai, Tran C, Reibel, Jacob B, Tamayo, Pablo, Godfrey, Jason T, Qian, Zhi Rong, Page, Asher N, Maciag, Karolina, Chan, Edmond M, Silkworth, Whitney, Labowsky, Mary T, Rozhansky, Lior, Mesirov, Jill P, Gillanders, William E, Ogino, Shuji, Hacohen, Nir, Gaudet, Suzanne, Eck, Michael J, Engelman, Jeffrey A, Corcoran, Ryan B, Wong, Kwok-Kin, Hahn, William C, Barbie, David A

“…Although the roles of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling in KRAS-driven tumorigenesis are well established,…”
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Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer by Liu, Yan, Marks, Kevin, Cowley, Glenn S, Carretero, Julian, Liu, Qingsong, Nieland, Thomas J F, Xu, Chunxiao, Cohoon, Travis J, Gao, Peng, Zhang, Yong, Chen, Zhao, Altabef, Abigail B, Tchaicha, Jeremy H, Wang, Xiaoxu, Choe, Sung, Driggers, Edward M, Zhang, Jianming, Bailey, Sean T, Sharpless, Norman E, Hayes, D Neil, Patel, Nirali M, Janne, Pasi A, Bardeesy, Nabeel, Engelman, Jeffrey A, Manning, Brendan D, Shaw, Reuben J, Asara, John M, Scully, Ralph, Kimmelman, Alec, Byers, Lauren A, Gibbons, Don L, Wistuba, Ignacio I, Heymach, John V, Kwiatkowski, David J, Kim, William Y, Kung, Andrew L, Gray, Nathanael S, Root, David E, Cantley, Lewis C, Wong, Kwok-Kin

“…The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non-small cell lung…”
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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice by Akbay, Esra A, Moslehi, Javid, Christensen, Camilla L, Saha, Supriya, Tchaicha, Jeremy H, Ramkissoon, Shakti H, Stewart, Kelly M, Carretero, Julian, Kikuchi, Eiki, Zhang, Haikuo, Cohoon, Travis J, Murray, Stuart, Liu, Wei, Uno, Kazumasa, Fisch, Sudeshna, Jones, Kristen, Gurumurthy, Sushma, Gliser, Camelia, Choe, Sung, Keenan, Marie, Son, Jaekyoung, Stanley, Illana, Losman, Julie A, Padera, Robert, Bronson, Roderick T, Asara, John M, Abdel-Wahab, Omar, Amrein, Philip C, Fathi, Amir T, Danial, Nika N, Kimmelman, Alec C, Kung, Andrew L, Ligon, Keith L, Yen, Katharine E, Kaelin, Jr, William G, Bardeesy, Nabeel, Wong, Kwok-Kin

“…Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-hydroxyglutaric…”
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Attempted Cardiopulmonary Bypass Venous Cannula Extraction Catheter by Cohoon, Travis J., King, Matthew R., Gharai, Fariba, Abolhoda, Amir, Sakwa, Marc, Shavelle, David M.

“…Myoepithelioma of the soft tissue is a rare entity that can mimic myxoma when presenting within the heart. We present a case where cardiopulmonary bypass…”
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Abstract LB-260: Identification of DTYMK and CHEK1 as therapeutic targets in LKB1 mutant non-small cell lung cancer by Liu, Yan, Cowley, Glenn S., Cohoon, Travis J., Root, David E., Kwok-kin, Wong

“…Abstract The LKB1 tumor suppressor encodes a key metabolic sensor that integrates cell growth and metabolism. LKB1 is mutationally inactivated in multiple…”
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Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer by Shimamura, Takeshi, Chen, Zhao, Soucheray, Margaret, Carretero, Julian, Kikuchi, Eiki, Tchaicha, Jeremy H., Gao, Yandhi, Cheng, Katherine A., Cohoon, Travis J., Qi, Jun, Akbay, Esra A., Kimmelman, Alec C., Kung, Andrew L., Bradner, James E., Wong, Kwok Kin

“…Abstract Amplification of MYC is one of the most common genetic alterations in lung cancer, contributing to a myriad of phenotypes associated with growth,…”
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Abstract PR09: Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS-mutant cancer models by Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.

“…Abstract Although KRAS is the most commonly mutated oncogene in human cancer, KRAS has proven difficult to target pharmacologically, and no effective therapies…”
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Extreme Angiographic-Physiologic Mismatch With Elevated Left Ventricular End-Diastolic Pressure by Cohoon, Travis J, Kern, Morton J

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