Search Results - "Cohn, Lillian"

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies by Cohn, Lillian B, Chomont, Nicolas, Deeks, Steven G

“…Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4 T cells and…”
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HIV-1 Integration Landscape during Latent and Active Infection by Cohn, Lillian B., Silva, Israel T., Oliveira, Thiago Y., Rosales, Rafael A., Parrish, Erica H., Learn, Gerald H., Hahn, Beatrice H., Czartoski, Julie L., McElrath, M. Juliana, Lehmann, Clara, Klein, Florian, Caskey, Marina, Walker, Bruce D., Siliciano, Janet D., Siliciano, Robert F., Jankovic, Mila, Nussenzweig, Michel C.

“…The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent proviruses. To characterize these latently infected cells, we…”
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Leptin receptor signaling in T cells is required for Th17 differentiation by Reis, Bernardo S, Lee, Kihyun, Fanok, Melania H, Mascaraque, Cristina, Amoury, Manal, Cohn, Lillian B, Rogoz, Aneta, Dallner, Olof S, Moraes-Vieira, Pedro M, Domingos, Ana I, Mucida, Daniel

“…The hormone leptin plays a key role in energy homeostasis, and the absence of either leptin or its receptor (LepR) leads to severe obesity and metabolic…”
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Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir by Mendoza, Pilar, Jackson, Julia R, Oliveira, Thiago Y, Gaebler, Christian, Ramos, Victor, Caskey, Marina, Jankovic, Mila, Nussenzweig, Michel C, Cohn, Lillian B

“…Antiretroviral therapy suppresses but does not cure HIV-1 infection due to the existence of a long-lived reservoir of latently infected cells. The reservoir…”
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Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence by Huang, Amy S, Ramos, Victor, Oliveira, Thiago Y, Gaebler, Christian, Jankovic, Mila, Nussenzweig, Michel C, Cohn, Lillian B

“…Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4+ T cells that can undergo clonal expansion in vivo. Expanded clones of CD4+ T cells…”
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Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation by Cohn, Lillian B., da Silva, Israel T., Valieris, Renan, Huang, Amy S., Lorenzi, Julio C. C., Cohen, Yehuda Z., Pai, Joy A., Butler, Allison L., Caskey, Marina, Jankovic, Mila, Nussenzweig, Michel C.

“…Despite suppressive combination antiretroviral therapy (ART), latent HIV-1 proviruses persist in patients. This latent reservoir is established within 48–72 h…”
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Impact of misclassified defective proviruses on HIV reservoir measurements by Reeves, Daniel B., Gaebler, Christian, Oliveira, Thiago Y., Peluso, Michael J., Schiffer, Joshua T., Cohn, Lillian B., Deeks, Steven G., Nussenzweig, Michel C.

“…Most proviruses persisting in people living with HIV (PWH) on antiretroviral therapy (ART) are defective. However, rarer intact proviruses almost always…”
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Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4 + T cells by Battivelli, Emilie, Dahabieh, Matthew S, Abdel-Mohsen, Mohamed, Svensson, J Peter, Tojal Da Silva, Israel, Cohn, Lillian B, Gramatica, Andrea, Deeks, Steven, Greene, Warner C, Pillai, Satish K, Verdin, Eric

“…Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The 'shock and kill' approach to a cure…”
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The immune response fails to control HIV early in initial virus spread by Cohn, Lillian B, Deeks, Steven G

“…Discontinued antiretroviral therapy (ART) results in uncontrolled HIV replication in most cases. How the virus population that persists during ART escapes…”
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Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA by Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Kreider, Edward F., Barton, John P., Learn, Gerald H., Oliveira, Thiago, Lavine, Christy L., Horwitz, Joshua A., Settler, Allison, Jankovic, Mila, Seaman, Michael S., Chakraborty, Arup K., Hahn, Beatrice H., Caskey, Marina, Nussenzweig, Michel C.

“…HIV-1–infected individuals harbor a latent reservoir of infected CD4⁺ T cells that is not eradicated by antiretroviral therapy (ART). This reservoir presents…”
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Relationship between intact HIV-1 proviruses in circulating CD4⁺ T cells and rebound viruses emerging during treatment interruption by Lu, Ching-Lan, Pai, Joy A., Nogueira, Lilian, Mendoza, Pilar, Gruell, Henning, Oliveira, Thiago Y., Barton, John, Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Klein, Florian, Caskey, Marina, Nussenzweig, Michel C., Jankovic, Mila

“…Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound…”
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Galectin-9 Levels as a Potential Predictor of Intact HIV Reservoir Decay by Serrano-Villar, Sergio, Gala, Akshay, Bacchetti, Peter, Hoh, Rebecca, di Germanio, Clara, Cohn, Lillian B, Henrich, Timothy J, Hunt, Peter W, Laird, Gregory M, Pillai, Satish K, Deeks, Steven G, Peluso, Michael J

“…During antiretroviral therapy (ART), the HIV reservoir exhibits variability as cells with intact genomes decay faster than those with defective genomes,…”
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Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation by Cohn, Lillian, Chatterjee, Bithi, Esselborn, Filipp, Smed-Sörensen, Anna, Nakamura, Norihiro, Chalouni, Cécile, Lee, Byoung-Chul, Vandlen, Richard, Keler, Tibor, Lauer, Peter, Brockstedt, Dirk, Mellman, Ira, Delamarre, Lélia

“…Human BDCA3(+) dendritic cells (DCs), the proposed equivalent to mouse CD8α(+) DCs, are widely thought to cross present antigens on MHC class I (MHCI)…”
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Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells by Chatterjee, Bithi, Smed-Sörensen, Anna, Cohn, Lillian, Chalouni, Cécile, Vandlen, Richard, Lee, Byoung-Chul, Widger, Jenifer, Keler, Tibor, Delamarre, Lélia, Mellman, Ira

“…Dendritic cells (DCs) can capture extracellular antigens and load resultant peptides on to MHC class I molecules, a process termed cross presentation. The…”
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HIV-1 reservoir dynamics in CD4+ T cells by Bruner, Katherine M, Cohn, Lillian B

“…PURPOSE OF REVIEWTo provide a summary of the recent data examining infected CD4+ T cell dynamics during ART and implications for cure strategies. RECENT…”
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Distinct gene expression by expanded clones of quiescent memory CD4 + T cells harboring intact latent HIV-1 proviruses by Weymar, Georg H J, Bar-On, Yotam, Oliveira, Thiago Y, Gaebler, Christian, Ramos, Victor, Hartweger, Harald, Breton, Gaëlle, Caskey, Marina, Cohn, Lillian B, Jankovic, Mila, Nussenzweig, Michel C

“…Antiretroviral therapy controls, but does not cure, HIV-1 infection due to a reservoir of rare CD4 T cells harboring latent proviruses. Little is known about…”
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HIV: Persistence through division by Cohn, Lillian B, Nussenzweig, Michel C

“…A long-lived latent reservoir for HIV-1 persists in CD4 T cells despite antiretroviral therapy and is the major barrier to cure. In this issue of JEM, Hosmane…”
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Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells by Smed-Sörensen, Anna, Chalouni, Cécile, Chatterjee, Bithi, Cohn, Lillian, Blattmann, Peter, Nakamura, Norihiro, Delamarre, Lélia, Mellman, Ira

“…Influenza A virus (IAV) infection is normally controlled by adaptive immune responses initiated by dendritic cells (DCs). We investigated the consequences of…”
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Dendritic cell-targeted vaccines by Cohn, Lillian, Delamarre, Lélia

“…Despite significant effort, the development of effective vaccines inducing strong and durable T-cell responses against intracellular pathogens and cancer cells…”
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Relationship between intact HIV-1 proviruses in circulating CD4^sup +^ T cells and rebound viruses emerging during treatment interruption by Lu, Ching-Lan, Pai, Joy A, Nogueira, Lilian, Mendoza, Pilar, Gruell, Henning, Oliveira, Thiago Y, Barton, John, Lorenzi, Julio C, Cohen, Yehuda Z, Cohn, Lillian B, Klein, Florian, Caskey, Marina, Nussenzweig, Michel C, Jankovic, Mila

“…Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound…”
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