Search Results - "Cohen, V I"

In vitro and in vivo m2 muscarinic subtype selectivity of some dibenzodiazepinones and pyridobenzodiazepinones by Cohen, Victor I, Jin, Biyun, McRee, R.Carter, Boulay, Sheila F, Cohen, Emil I, Sood, Virendar K, Zeeberg, Barry R, Reba, Richard C

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype receptors in cortical and hippocampal regions of the human brain…”
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A novel m2-selective muscarinic antagonist: binding characteristics and autoradiographic distribution in rat brain by Gitler, M S, Reba, R C, Cohen, V I, Rzeszotarski, W J, Jin, B, Baumgold, J

“…Although several m2-selective muscarinic antagonists have been described, they are not particularly potent. Thus, the development of potent m2-selective…”
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In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT by Cohen, V I, Zeeberg, B R, Boulay, S F, Sood, V K, Rayeq, M R, Danesh, R A, McPherson, D W, Reba, R C

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in cortical and hippocampal regions of the human brain…”
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A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype by Gitler, M S, Cohen, V I, De la Cruz, R, Boulay, S F, Jin, B, Zeeberg, B R, Reba, R C

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain…”
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Specific binding component of the “inactive” stereoisomer (S,S)-[ 125I]IQNB to rat brain muscarinic receptors in vivo by Boulay, Sheila F., McRee, R.Carter, Cohen, Victor I., Sood, Virendar K., Zeeberg, Barry R., Reba, Richard C.

“…In vivo nonspecific binding can be estimated using the inactive stereoisomer of a receptor radioligand. However, the binding of the inactive stereoisomer may…”
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Muscarinic receptor subtype selectivity of novel heterocyclic QNB analogues by Baumgold, J, Cohen, V I, Paek, R, Reba, R C

“…In an effort at synthesizing centrally-active subtype-selective antimuscarinic agents, we derivatized QNB (quinuclidinyl benzilate), a potent muscarinic…”
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Novel potent and m2-selective antimuscarinic compounds which penetrate the blood-brain barrier by COHEN, V. I, JIN, B, GITLER, M. S, DE LA CRUZ, R. A, BOULAY, S. F, SOOD, V. K, ZEEBERG, B. R, REBA, R. C

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Synthesis and structure-activity relationships of new muscarinic antagonists by Cohen, V I, Gibson, R E, Reba, R C

“…In an attempt to develop more selective muscarinic acetylcholine receptor (m-AcChR) antagonists, (R)-1-azabicyclo[2.2.2]oct-3-yl-thioxanthene-9-carboxylate,…”
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Autoradiographic evidence that 3-quinuclidinyl-4-fluorobenzilate (FQNB) displays in vivo selectivity for the m2 subtype by Boulay, S F, Sood, V K, Rayeq, M R, Cohen, V I, Zeeberg, B R, Reba, R C

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in cortical and hippocampal regions of the human brain…”
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Autoradiographic Evidence That QNB Displays in Vivo Selectivity for the m2 Subtype by McRee, R.C., Boulay, S.F., Sood, V.K., Cohen, E.I., Cohen, V.I., Gitler, M.S., Zeeberg, B.R., Gibson, R.E., Reba, R.C.

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in cortical and hippocampal regions of the human brain…”
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Synthesis and structure-activity relationship of some 5-[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H-benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics by COHEN, V. I, BAUMGOLD, J, JIN, B, DE LA CRUZ, R, RZESZOTARSKI, W. J, REBA, R. C

“…A series of 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]- 10,11-dihydro-5H-dibenzo[b,e][1,4]-diazepin-11-ones were prepared as potential M2-selective…”
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Autoradiographic Evidence That Quinuclidinyl 4-(Bromophenyl)-2-thienylglycolate (QBPTG) Displays in Vivo Selectivity for the Muscarinic m2 Subtype by Boulay, S.F., Sood, V.K., Rayeq, M.R., McRee, R.C., Cohen, E.I., Cohen, V.I., Zeeberg, B.R., Reba, R.C.

“…Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in cortical and hippocampal regions of the human brain…”
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Preparation and properties of (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-[125I]iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-[125I]iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals by Cohen, V I, Rzeszotarski, W J, Gibson, R E, Fan, L H, Reba, R C

“…rac-4-Nitrobenzilic acid was synthesized and resolved with quinidine and quinine to give the corresponding (R)- and (S)-salts. The resolved diastereomeric…”
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In Vitro and In Vivo Characteristics of [Iodine-125] 3-(R)-Quinuclidinyl (S)-4-Iodobenzilate by Gibson, Raymond E, Schneidau, Timothy A, Cohen, Victor I, Sood, Virendar, Ruch, Jennifer, Melograna, John, Eckelman, William C, Reba, Richard C

“…The radioiodinated muscarinic acetylcholine receptor antagonist, [125I] 3-quinuclidinyl 4-iodobenzilate, has two high affinity diastereomeric forms, the (R,R)…”
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Comparison of the in vivo rat brain regional pharmacokinetics of [3H]QNB, (R,S)-[125I]-4IQNB, and (R,R)-[125I]-4IQNB binding to the muscarinic acetylcholine receptor in relationship to the regional subtype composition by Boulay, S F, Gitler, M S, Sood, V K, Cohen, V I, Zeeberg, B R, Reba, R C

“…We have used the dissection of selected rat brain regions to compare the in vivo pharmacokinetics of [3H]QNB, (R,S)-[125I]-4IQNB, and (R,R)-[125I]-4IQNB…”
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Synthesis and muscarinic cholinergic receptor affinities of 3-quinuclidinyl .alpha.-(alkoxyalkyl)-.alpha.-aryl-.alpha.-hydroxyacetates by Cohen, Victor I, Gibson, Raymond E, Fan, Linda H, De la Cruz, Rosanna, Gitler, Miriam S, Hariman, Erin, Reba, Richard C

“…Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the…”
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Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain by Makunts, Tigran, Cohen, Isaac V, Lee, Kelly C, Abagyan, Ruben

“…Currently approved monoamine modulating antidepressant and anxiolytic pharmaceutics fail in over one third of patients due to delayed and variable therapeutic…”
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Synthesis and receptor affinities of new 3-quinuclidinyl alpha-heteroaryl-alpha-aryl-alpha-hydroxyacetates by Cohen, V I, Gibson, R E, Fan, L H, de la Cruz, R, Gitler, M S, Hariman, E, Reba, R C

“…Five analogues of 3-quinuclidinyl benzilate were prepared in which one phenyl ring was substituted by a heterocycle; a bromine was included on either the…”
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Molecular modeling of the interaction of diagnostic radiopharmaceuticals with receptor proteins: m2 antagonist binding to the muscarinic m2 subtype receptor by Kapp, O H, Siemion, J, Eckelman, W C, Cohen, V I, Reba, R C

“…Models of the m2 muscarinic receptor have been built and acetylcholine and an antagonist of the quinuclidinyl benzilate family docked to the putative active…”
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Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones by Cohen, Isaac V., Cirulli, Elizabeth T., Mitchell, Matthew W., Jonsson, Thomas J., Yu, James, Shah, Naisha, Spector, Tim D., Guo, Lining, Venter, J. Craig, Telenti, Amalio

“…Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of…”
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