Search Results - "Cohen, Samuel"

Secondary nucleation in amyloid formation by Törnquist, Mattias, Michaels, Thomas C T, Sanagavarapu, Kalyani, Yang, Xiaoting, Meisl, Georg, Cohen, Samuel I A, Knowles, Tuomas P J, Linse, Sara

“…Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the same peptide or protein has emerged in the past two decades as a…”
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Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide by Michaels, Thomas C. T., Šarić, Andela, Curk, Samo, Bernfur, Katja, Arosio, Paolo, Meisl, Georg, Dear, Alexander J., Cohen, Samuel I. A., Dobson, Christopher M., Vendruscolo, Michele, Linse, Sara, Knowles, Tuomas P. J.

“…Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the…”
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Analytical Solution to the Kinetics of Breakable Filament Assembly by Knowles, Tuomas P.J, Waudby, Christopher A, Devlin, Glyn L, Cohen, Samuel I.A, Aguzzi, Adriano, Vendruscolo, Michele, Terentjev, Eugene M, Welland, Mark E, Dobson, Christopher M

“…We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the…”
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From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation by Cohen, Samuel I.A., Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P.J.

“…The ability to relate bulk experimental measurements of amyloid formation to the microscopic assembly processes that underlie protein aggregation is critical…”
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A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers by Cohen, Samuel I A, Arosio, Paolo, Presto, Jenny, Kurudenkandy, Firoz Roshan, Biverstål, Henrik, Dolfe, Lisa, Dunning, Christopher, Yang, Xiaoting, Frohm, Birgitta, Vendruscolo, Michele, Johansson, Jan, Dobson, Christopher M, Fisahn, André, Knowles, Tuomas P J, Linse, Sara

“…Aβ peptide aggregation is associated with Alzheimer's disease, and Aβ fibrils can catalyze formation of toxic oligomers. Molecular chaperone Brichos binds to…”
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Phase Transitions of Associative Biomacromolecules by Pappu, Rohit V., Cohen, Samuel R., Dar, Furqan, Farag, Mina, Kar, Mrityunjoy

“…Multivalent proteins and nucleic acids, collectively referred to as multivalent associative biomacromolecules, provide the driving forces for the formation and…”
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Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein by Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David

“…Here, we use single-molecule techniques to study the aggregation of α-synuclein, the protein whose misfolding and deposition is associated with Parkinson's…”
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Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies by Linse, Sara, Scheidt, Tom, Bernfur, Katja, Vendruscolo, Michele, Dobson, Christopher M., Cohen, Samuel I. A., Sileikis, Eimantas, Lundqvist, Martin, Qian, Fang, O’Malley, Tiernan, Bussiere, Thierry, Weinreb, Paul H., Xu, Catherine K., Meisl, Georg, Devenish, Sean R. A., Knowles, Tuomas P. J., Hansson, Oskar

“…The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many…”
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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism by Cohen, Samuel I. A., Linse, Sara, Luheshi, Leila M., Hellstrand, Erik, White, Duncan A., Rajah, Luke, Otzen, Daniel E., Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J.

“…The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature…”
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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides by Meisl, Georg, Yang, Xiaoting, Hellstrand, Erik, Frohm, Birgitta, Kirkegaard, Julius B, Cohen, Samuel I A, Dobson, Christopher M, Linse, Sara, Knowles, Tuomas P J

“…The two major forms of the amyloid-beta (Aβ) peptide found in plaques in patients suffering from Alzheimer’s disease, Aβ40 and Aβ42, only differ by two amino…”
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Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations by Farag, Mina, Cohen, Samuel R., Borcherds, Wade M., Bremer, Anne, Mittag, Tanja, Pappu, Rohit V.

“…Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to…”
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Cell proliferation and carcinogenesis: an approach to screening for potential human carcinogens by Cohen, Samuel M

“…Cancer arises from multiple genetic errors occurring in a single stem cell (clonality). Every time DNA replicates, mistakes occur. Thus, agents can increase…”
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Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease by Habchi, Johnny, Chia, Sean, Limbocker, Ryan, Mannini, Benedetta, Ahn, Minkoo, Perni, Michele, Hansson, Oskar, Arosio, Paolo, Kumita, Janet R., Challa, Pavan Kumar, Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele

“…The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer’s disease (AD). The use of chemical kinetics has…”
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Eutychianorum furor! Heresiological Comparison and the Invention of Eutychians in Leo I’s Christological Polemic by Cohen, Samuel

“…This essay examines the use of heresiological rhetoric in the letters and tractates of Leo I (bishop of Rome, 440–461) written in defense of the Council of…”
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Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide by Cohen, Samuel I. A., Cukalevski, Risto, Michaels, Thomas C. T., Šarić, Anđela, Törnquist, Mattias, Vendruscolo, Michele, Dobson, Christopher M., Buell, Alexander K., Knowles, Tuomas P. J., Linse, Sara

“…Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have…”
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Observation of spatial propagation of amyloid assembly from single nuclei by Knowles, Tuomas P. J, White, Duncan A, Abate, Adam R, Agresti, Jeremy J, Cohen, Samuel I. A, Sperling, Ralph A, De Genst, Erwin J, Dobson, Christopher M, Weitz, David A

“…The crucial early stages of amyloid growth, in which normally soluble proteins are converted into fibrillar nanostructures, are challenging to study using…”
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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity by Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.

“…The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related syndromes. We show that squalamine, a natural product with known…”
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The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia by Cohen, Samuel M, Tsien, Richard W, Goff, Donald C, Halassa, Michael M

“…Abstract While the dopamine hypothesis has dominated schizophrenia research for several decades, more recent studies have highlighted the role of fast synaptic…”
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Scaling behaviour and rate-determining steps in filamentous self-assembly by Meisl, Georg, Rajah, Luke, Cohen, Samuel A I, Pfammatter, Manuela, Šarić, Anđela, Hellstrand, Erik, Buell, Alexander K, Aguzzi, Adriano, Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M, Knowles, Tuomas P J

“…The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such…”
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Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine by Perni, Michele, Flagmeier, Patrick, Limbocker, Ryan, Cascella, Roberta, Aprile, Francesco A, Galvagnion, Céline, Heller, Gabriella T, Meisl, Georg, Chen, Serene W, Kumita, Janet R, Challa, Pavan K, Kirkegaard, Julius B, Cohen, Samuel I. A, Mannini, Benedetta, Barbut, Denise, Nollen, Ellen A. A, Cecchi, Cristina, Cremades, Nunilo, Knowles, Tuomas P. J, Chiti, Fabrizio, Zasloff, Michael, Vendruscolo, Michele, Dobson, Christopher M

“…The aggregation of α-synuclein, an intrinsically disordered protein that is highly abundant in neurons, is closely associated with the onset and progression of…”
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