Search Results - "Cohen, Malkiel A"

Molecular Criteria for Defining the Naive Human Pluripotent State by Theunissen, Thorold W., Friedli, Marc, He, Yupeng, Planet, Evarist, O’Neil, Ryan C., Markoulaki, Styliani, Pontis, Julien, Wang, Haoyi, Iouranova, Alexandra, Imbeault, Michaël, Duc, Julien, Cohen, Malkiel A., Wert, Katherine J., Castanon, Rosa, Zhang, Zhuzhu, Huang, Yanmei, Nery, Joseph R., Drotar, Jesse, Lungjangwa, Tenzin, Trono, Didier, Ecker, Joseph R., Jaenisch, Rudolf

“…Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate…”
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops by Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.

“…There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that…”
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Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs by Song, Yuelin, van den Berg, Patrick R., Markoulaki, Styliani, Soldner, Frank, Dall’Agnese, Alessandra, Henninger, Jonathan E., Drotar, Jesse, Rosenau, Nicholas, Cohen, Malkiel A., Young, Richard A., Semrau, Stefan, Stelzer, Yonatan, Jaenisch, Rudolf

“…Variable levels of DNA methylation have been reported at tissue-specific differential methylation regions (DMRs) overlapping enhancers, including…”
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Intravital imaging of mouse embryos by Huang, Qiang, Cohen, Malkiel A, Alsina, Fernando C, Devlin, Garth, Garrett, Aliesha, McKey, Jennifer, Havlik, Patrick, Rakhilin, Nikolai, Wang, Ergang, Xiang, Kun, Mathews, Parker, Wang, Lihua, Bock, Cheryl, Ruthig, Victor, Wang, Yi, Negrete, Marcos, Wong, Chi Wut, Murthy, Preetish K L, Zhang, Shupei, Daniel, Andrea R, Kirsch, David G, Kang, Yubin, Capel, Blanche, Asokan, Aravind, Silver, Debra L, Jaenisch, Rudolf, Shen, Xiling

“…Embryonic development is a complex process that is unamenable to direct observation. In this study, we implanted a window to the mouse uterus to visualize the…”
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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras by Cohen, Malkiel A., Zhang, Shupei, Sengupta, Satyaki, Ma, Haiting, Bell, George W., Horton, Brendan, Sharma, Bandana, George, Rani E., Spranger, Stefani, Jaenisch, Rudolf

“…Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here, we establish a platform that allows the…”
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Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease by Sarkar, Sovan, Carroll, Bernadette, Buganim, Yosef, Maetzel, Dorothea, Ng, Alex H.M., Cassady, John P., Cohen, Malkiel A., Chakraborty, Souvik, Wang, Haoyi, Spooner, Eric, Ploegh, Hidde, Gsponer, Joerg, Korolchuk, Viktor I., Jaenisch, Rudolf

“…Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also…”
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Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos by Cohen, Malkiel A., Wert, Katherine J., Goldmann, Johanna, Markoulaki, Styliani, Buganim, Yosef, Fu, Dongdong, Jaenisch, Rudolf

“…The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC…”
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Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation by Cohen, Malkiel A., Markoulaki, Styliani, Jaenisch, Rudolf

“…Chimeric mice have been generated by injecting pluripotent stem cells into morula-to-blastocyst stage mouse embryo or by introducing more mature cells into…”
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The Lamina Propria of Adult Human Oral Mucosa Harbors a Novel Stem Cell Population by Marynka‐Kalmani, Keren, Treves, Sandra, Yafee, Miri, Rachima, Heled, Gafni, Yossi, Cohen, Malkiel A., Pitaru, Sandu

“…The highly regenerative capacity of the human adult oral mucosa suggests the existence of a robust stem cell (SC) population in its lamina propria (OMLP). The…”
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A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity by D’Alessio, Ana C., Fan, Zi Peng, Wert, Katherine J., Baranov, Petr, Cohen, Malkiel A., Saini, Janmeet S., Cohick, Evan, Charniga, Carol, Dadon, Daniel, Hannett, Nancy M., Young, Michael J., Temple, Sally, Jaenisch, Rudolf, Lee, Tong Ihn, Young, Richard A.

“…Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can be induced through the activity of just a small number of core…”
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Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy by Seranova, Elena, Palhegyi, Adina Maria, Verma, Surbhi, Dimova, Simona, Lasry, Rachel, Naama, Moriyah, Sun, Congxin, Barrett, Timothy, Rosenstock, Tatiana Rosado, Kumar, Dhiraj, Cohen, Malkiel A., Buganim, Yosef, Sarkar, Sovan

“…Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis, and human health. The housekeeping functions of…”
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Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype by Omer Javed, Attya, Li, Yun, Muffat, Julien, Su, Kuan-Chung, Cohen, Malkiel A., Lungjangwa, Tenzin, Aubourg, Patrick, Cheeseman, Iain M., Jaenisch, Rudolf

“…Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the…”
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Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation by Lefler, Sharon, Cohen, Malkiel A, Kantor, Gal, Cheishvili, David, Even, Aviel, Birger, Anastasya, Turetsky, Tikva, Gil, Yaniv, Even-Ram, Sharona, Aizenman, Einat, Bashir, Nibal, Maayan, Channa, Razin, Aharon, Reubinoff, Benjamim E, Weil, Miguel

“…A splicing mutation in the IKBKAP gene causes Familial Dysautonomia (FD), affecting the IKAP protein expression levels and proper development and function of…”
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Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation by Edupuganti, Raghu Ram, Harikumar, Arigela, Aaronson, Yair, Biran, Alva, Sailaja, Badi Sri, Nissim-Rafinia, Malka, Azad, Gajendra Kumar, Cohen, Malkiel A., Park, Jung Eun, Shivalila, Chikdu S., Markoulaki, Styliani, Sze, Siu Kwan, Jaenisch, Rudolf, Meshorer, Eran

“…Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell…”
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Enriched population of PNS neurons derived from human embryonic stem cells as a platform for studying peripheral neuropathies by Valensi-Kurtz, Moran, Lefler, Sharon, Cohen, Malkiel A, Aharonowiz, Michal, Cohen-Kupiec, Rachel, Sheinin, Anton, Ashery, Uri, Reubinoff, Benjamin, Weil, Miguel

“…The absence of a suitable cellular model is a major obstacle for the study of peripheral neuropathies. Human embryonic stem cells hold the potential to be…”
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Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells by Idelson, Maria, Alper, Ruslana, Obolensky, Alexey, Ben-Shushan, Etti, Hemo, Itzhak, Yachimovich-Cohen, Nurit, Khaner, Hanita, Smith, Yoav, Wiser, Ofer, Gropp, Michal, Cohen, Malkiel A., Even-Ram, Sharona, Berman-Zaken, Yael, Matzrafi, Limor, Rechavi, Gideon, Banin, Eyal, Reubinoff, Benjamin

“…Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis…”
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Methods to Screen the Adhesion of Fish Cells on Plant‑, Algal- and Fungal-Derived Biomaterials by Joyce, Connor M., Gordon, Edward B., McGivney, Aelish, Li, Xinxin, Lim, Taehwan, Cohen, Malkiel A., Kaplan, David L.

“…Cellular agriculture, an alternative and innovative approach to sustainable food production, has gained momentum in recent years. However, there is limited…”
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Neural differentiation of human ES cells by Cohen, Malkiel A, Itsykson, Pavey, Reubinoff, Benjamin E

“…Human embryonic stem cells (hESCs) may be converted into highly enriched cultures of neural precursors under defined culture conditions. The neural precursors…”
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SMARCE1 is required for the invasive progression of in situ cancers by Sokol, Ethan S., Feng, Yu-Xiong, Jin, Dexter X., Tizabi, Minu D., Miller, Daniel H., Cohen, Malkiel A., Sanduja, Sandhya, Reinhardt, Ferenc, Pandey, Jai, Superville, Daphne A., Jaenisch, Rudolf, Gupta, Piyush B.

“…Advances in mammography have sparked an exponential increase in the detection of early-stage breast lesions, most commonly ductal carcinoma in situ (DCIS)…”
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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency by Sun, Congxin, Seranova, Elena, Cohen, Malkiel A., Chipara, Miruna, Roberts, Jennie, Astuti, Dewi, Palhegyi, Adina M., Acharjee, Animesh, Sedlackova, Lucia, Kataura, Tetsushi, Otten, Elsje G., Panda, Prashanta K., Lara-Reyna, Samuel, Korsgen, Miriam E., Kauffman, Kevin J., Huerta-Uribe, Alejandro, Zatyka, Malgorzata, Silva, Luiz F.S.E., Torresi, Jorge, Zhang, Shupei, Hughes, Georgina W., Ward, Carl, Kuechler, Erich R., Cartwright, David, Trushin, Sergey, Trushina, Eugenia, Sahay, Gaurav, Buganim, Yosef, Lavery, Gareth G., Gsponer, Joerg, Anderson, Daniel G., Frickel, Eva-Maria, Rosenstock, Tatiana R., Barrett, Timothy, Maddocks, Oliver D.K., Tennant, Daniel A., Wang, Haoyi, Jaenisch, Rudolf, Korolchuk, Viktor I., Sarkar, Sovan

“…Autophagy is a homeostatic process critical for cellular survival, and its malfunction is implicated in human diseases including neurodegeneration. Loss of…”
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