Search Results - "Cohen, Limor"
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Highly Sensitive and Multiplexed Protein Measurements
Published in Chemical reviews (09-01-2019)“…Proteins are involved in many biological processes. Misfolded, truncated, or mutated proteins as well as over- or underexpressed proteins have been implicated…”
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2
Single-Molecule Arrays for Protein and Nucleic Acid Analysis
Published in Annual review of analytical chemistry (Palo Alto, Calif.) (12-06-2017)“…The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement…”
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3
Digital direct detection of microRNAs using single molecule arrays
Published in Nucleic acids research (21-08-2017)“…MicroRNAs (miRNAs) are involved in many biological pathways, and detecting miRNAs accurately is critical for diagnosing a variety of diseases including cancer…”
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4
Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC
Published in Journal for immunotherapy of cancer (01-10-2020)“…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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5
IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer
Published in Cell death & disease (20-09-2018)“…Genomic alterations (GA) in PIK3CA leads to the hyper-activation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway in more than 20% of…”
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Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines
Published in Clinical biochemistry (01-03-2019)“…In this study, we evaluated the impact of clinical sample handling and processing on IL-6, IL-10, IFNγ, and IL-2 measurements in plasma. We collected whole…”
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A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation
Published in Molecular cancer (14-03-2024)“…Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite…”
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TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer
Published in Cancers (03-02-2020)“…Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known…”
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Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip
Published in Advanced science (01-05-2022)“…Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic…”
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10
Extracellular pH Regulates Zinc Signaling via an Asp Residue of the Zinc-sensing Receptor (ZnR/GPR39)
Published in The Journal of biological chemistry (28-09-2012)“…Zinc activates a specific Zn2+-sensing receptor, ZnR/GPR39, and thereby triggers cellular signaling leading to epithelial cell proliferation and survival…”
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Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin
Published in PloS one (24-04-2012)“…Zinc enhances epithelial proliferation, protects the digestive epithelial layer and has profound antiulcerative and antidiarrheal roles in the colon. Despite…”
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12
MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
Published in Journal for immunotherapy of cancer (01-03-2022)“…BackgroundAlthough the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has…”
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13
Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy
Published in Frontiers in oncology (22-01-2019)“…Despite of remarkable progress made in the head and neck cancer (HNC) therapy, the survival rate of this metastatic disease remain low. Tailoring the…”
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14
Single-molecule analysis of nucleic acid biomarkers – A review
Published in Analytica chimica acta (08-06-2020)“…Nucleic acids are important biomarkers for disease detection, monitoring, and treatment. Advances in technologies for nucleic acid analysis have enabled…”
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15
Single Molecule Protein Detection with Attomolar Sensitivity Using Droplet Digital Enzyme-Linked Immunosorbent Assay
Published in ACS nano (25-08-2020)“…Many proteins are present at low concentrations in biological samples, and therefore, techniques for ultrasensitive protein detection are necessary. To…”
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Evaluation of Antibody Biotinylation Approaches for Enhanced Sensitivity of Single Molecule Array (Simoa) Immunoassays
Published in Bioconjugate chemistry (17-10-2018)“…In this study, we evaluated the performance of Single Molecule Array (Simoa) immunoassays based on various detection antibody biotinylation approaches. Simoa…”
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17
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
Published in Nature (London) (14-12-2023)“…In mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate…”
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The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-08-2016)“…Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We…”
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Elucidating siRNA Cellular Delivery Mechanism Mediated by Quaternized Starch Nanoparticles
Published in Small (Weinheim an der Bergstrasse, Germany) (02-10-2024)“…Starch-based nanoparticles are highly utilized in the realm of drug delivery taking advantage of their biocompatibility and biodegradability. Studies have…”
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Competitive Immunoassays for the Detection of Small Molecules Using Single Molecule Arrays
Published in Journal of the American Chemical Society (26-12-2018)“…Small-molecule detection is important for many applications including clinical diagnostics, drug discovery, and measurements of environmental samples and…”
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