Search Results - "Cohen, Limor"

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  1. 1

    Highly Sensitive and Multiplexed Protein Measurements by Cohen, Limor, Walt, David R

    Published in Chemical reviews (09-01-2019)
    “…Proteins are involved in many biological processes. Misfolded, truncated, or mutated proteins as well as over- or underexpressed proteins have been implicated…”
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    Single-Molecule Arrays for Protein and Nucleic Acid Analysis by Cohen, Limor, Walt, David R

    “…The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement…”
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  3. 3

    Digital direct detection of microRNAs using single molecule arrays by Cohen, Limor, Hartman, Mark R, Amardey-Wellington, Aaron, Walt, David R

    Published in Nucleic acids research (21-08-2017)
    “…MicroRNAs (miRNAs) are involved in many biological pathways, and detecting miRNAs accurately is critical for diagnosing a variety of diseases including cancer…”
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  4. 4

    Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC by Keegan, Alissa, Ricciuti, Biagio, Garden, Padric, Cohen, Limor, Nishihara, Reiko, Adeni, Anika, Paweletz, Cloud, Supplee, Julianna, Jänne, Pasi A, Severgnini, Mariano, Awad, Mark M, Walt, David R

    Published in Journal for immunotherapy of cancer (01-10-2020)
    “…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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    IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer by Zorea, Jonatan, Prasad, Manu, Cohen, Limor, Li, Nan, Schefzik, Roman, Ghosh, Susmita, Rotblat, Barak, Brors, Benedikt, Elkabets, Moshe

    Published in Cell death & disease (20-09-2018)
    “…Genomic alterations (GA) in PIK3CA leads to the hyper-activation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway in more than 20% of…”
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  6. 6

    Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines by Cohen, Limor, Keegan, Alissa, Melanson, Stacy E.F., Walt, David R.

    Published in Clinical biochemistry (01-03-2019)
    “…In this study, we evaluated the impact of clinical sample handling and processing on IL-6, IL-10, IFNγ, and IL-2 measurements in plasma. We collected whole…”
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  7. 7

    A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation by Peng, Xin, Huang, Xin, Lulu, Talal Ben, Jia, Wenqing, Zhang, Shaolu, Cohen, Limor, Huang, Shengfan, Fan, Jindian, Chen, Xi, Liu, Shanshan, Wang, Yongzhe, Wang, Kailin, Isoyama, Sho, Dan, Shingo, Wang, Feng, Zhang, Zhe, Elkabets, Moshe, Kong, Dexin

    Published in Molecular cancer (14-03-2024)
    “…Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite…”
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  8. 8

    TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer by Yegodayev, Ksenia M, Novoplansky, Ofra, Golden, Artemiy, Prasad, Manu, Levin, Liron, Jagadeeshan, Sankar, Zorea, Jonathan, Dimitstein, Orr, Joshua, Ben-Zion, Cohen, Limor, Khrameeva, Ekaterina, Elkabets, Moshe

    Published in Cancers (03-02-2020)
    “…Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known…”
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    Extracellular pH Regulates Zinc Signaling via an Asp Residue of the Zinc-sensing Receptor (ZnR/GPR39) by Cohen, Limor, Asraf, Hila, Sekler, Israel, Hershfinkel, Michal

    Published in The Journal of biological chemistry (28-09-2012)
    “…Zinc activates a specific Zn2+-sensing receptor, ZnR/GPR39, and thereby triggers cellular signaling leading to epithelial cell proliferation and survival…”
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  11. 11

    Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin by Cohen, Limor, Azriel-Tamir, Hagit, Arotsker, Natan, Sekler, Israel, Hershfinkel, Michal

    Published in PloS one (24-04-2012)
    “…Zinc enhances epithelial proliferation, protects the digestive epithelial layer and has profound antiulcerative and antidiarrheal roles in the colon. Despite…”
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    Single-molecule analysis of nucleic acid biomarkers – A review by Gilboa, Tal, Garden, Padric M., Cohen, Limor

    Published in Analytica chimica acta (08-06-2020)
    “…Nucleic acids are important biomarkers for disease detection, monitoring, and treatment. Advances in technologies for nucleic acid analysis have enabled…”
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  15. 15

    Single Molecule Protein Detection with Attomolar Sensitivity Using Droplet Digital Enzyme-Linked Immunosorbent Assay by Cohen, Limor, Cui, Naiwen, Cai, Yamei, Garden, Padric M, Li, Xiang, Weitz, David A, Walt, David R

    Published in ACS nano (25-08-2020)
    “…Many proteins are present at low concentrations in biological samples, and therefore, techniques for ultrasensitive protein detection are necessary. To…”
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  16. 16

    Evaluation of Antibody Biotinylation Approaches for Enhanced Sensitivity of Single Molecule Array (Simoa) Immunoassays by Cohen, Limor, Walt, David R

    Published in Bioconjugate chemistry (17-10-2018)
    “…In this study, we evaluated the performance of Single Molecule Array (Simoa) immunoassays based on various detection antibody biotinylation approaches. Simoa…”
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  17. 17

    Molecularly defined and spatially resolved cell atlas of the whole mouse brain by Zhang, Meng, Pan, Xingjie, Jung, Won, Halpern, Aaron R., Eichhorn, Stephen W., Lei, Zhiyun, Cohen, Limor, Smith, Kimberly A., Tasic, Bosiljka, Yao, Zizhen, Zeng, Hongkui, Zhuang, Xiaowei

    Published in Nature (London) (14-12-2023)
    “…In mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate…”
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  18. 18

    The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis by Sunuwar, Laxmi, Medini, Michal, Cohen, Limor, Sekler, Israel, Hershfinkel, Michal

    “…Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We…”
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    Elucidating siRNA Cellular Delivery Mechanism Mediated by Quaternized Starch Nanoparticles by Amar-Lewis, Eliz, Cohen, Limor, Chintakunta, Ramesh, Benafsha, Chen, Lavi, Yael, Goldbart, Riki, Traitel, Tamar, Gheber, Levi A, Kost, Joseph

    “…Starch-based nanoparticles are highly utilized in the realm of drug delivery taking advantage of their biocompatibility and biodegradability. Studies have…”
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  20. 20

    Competitive Immunoassays for the Detection of Small Molecules Using Single Molecule Arrays by Wang, Xu, Cohen, Limor, Wang, Jun, Walt, David R

    Published in Journal of the American Chemical Society (26-12-2018)
    “…Small-molecule detection is important for many applications including clinical diagnostics, drug discovery, and measurements of environmental samples and…”
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