Search Results - "Cohen, Clemens"

Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus by Chuang, Peter Y, Dai, Yan, Liu, Ruijie, He, Helen, Kretzler, Matthias, Jim, Belinda, Cohen, Clemens D, He, John C

“…The number of kidney podocytes is reduced in diabetic nephropathy. Advanced glycation end products (AGEs) accumulate in patients with diabetes and promote the…”
Get full text

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease by SHARMA, Kumar, KARL, Bethany, DIAMOND-STANIC, Maggie, LINDENMEYER, Maja T, FORSBLOM, Carol, WEI WU, IX, Joachim H, IDEKER, Trey, KOPP, Jeffrey B, NIGAM, Sanjay K, COHEN, Clemens D, GROOP, Per-Henrik, MATHEW, Anna V, BARSHOP, Bruce A, NATARAJAN, Loki, NYHAN, William L, NAVIAUX, Robert K, GANGOITI, Jon A, WASSEL, Christina L, SAITO, Rintaro, MINYA PU, SHARMA, Shoba, YOU, Young-Hyun, LIN WANG

“…Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney disease are available. This study used gas chromatography-mass…”
Get full text

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis by Berthier, Celine C, Bethunaickan, Ramalingam, Gonzalez-Rivera, Tania, Nair, Viji, Ramanujam, Meera, Zhang, Weijia, Bottinger, Erwin P, Segerer, Stephan, Lindenmeyer, Maja, Cohen, Clemens D, Davidson, Anne, Kretzler, Matthias

“…Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus. Therapeutic studies in mouse LN models do not always predict outcomes of human…”
Get full text

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice by Gödel, Markus, Hartleben, Björn, Herbach, Nadja, Liu, Shuya, Zschiedrich, Stefan, Lu, Shun, Debreczeni-Mór, Andrea, Lindenmeyer, Maja T, Rastaldi, Maria-Pia, Hartleben, Götz, Wiech, Thorsten, Fornoni, Alessia, Nelson, Robert G, Kretzler, Matthias, Wanke, Rüdiger, Pavenstädt, Hermann, Kerjaschki, Dontscho, Cohen, Clemens D, Hall, Michael N, Rüegg, Markus A, Inoki, Ken, Walz, Gerd, Huber, Tobias B

“…Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity, represent a major health issue. However, they remain poorly…”
Get full text

Defining cell-type specificity at the transcriptional level in human disease by Ju, Wenjun, Greene, Casey S, Eichinger, Felix, Nair, Viji, Hodgin, Jeffrey B, Bitzer, Markus, Lee, Young-Suk, Zhu, Qian, Kehata, Masami, Li, Min, Jiang, Song, Rastaldi, Maria Pia, Cohen, Clemens D, Troyanskaya, Olga G, Kretzler, Matthias

“…Cell-lineage-specific transcripts are essential for differentiated tissue function, implicated in hereditary organ failure, and mediate acquired chronic…”
Get full text

Urinary Soluble CD163 in Active Renal Vasculitis by O'Reilly, Vincent P, Wong, Limy, Kennedy, Claire, Elliot, Louise A, O'Meachair, Shane, Coughlan, Alice Marie, O'Brien, Eoin C, Ryan, Michelle M, Sandoval, Diego, Connolly, Emma, Dekkema, Gerjan J, Lau, Jiaying, Abdulahad, Wayel H, Sanders, Jan-Stephan F, Heeringa, Peter, Buckley, Colm, O'Brien, Cathal, Finn, Stephen, Cohen, Clemens D, Lindemeyer, Maja T, Hickey, Fionnuala B, O'Hara, Paul V, Feighery, Conleth, Moran, Sarah M, Mellotte, George, Clarkson, Michael R, Dorman, Anthony J, Murray, Patrick T, Little, Mark A

“…A specific biomarker that can separate active renal vasculitis from other causes of renal dysfunction is lacking, with a kidney biopsy often being required…”
Get full text

Keratins are novel markers of renal epithelial cell injury by Djudjaj, Sonja, Papasotiriou, Marios, Bülow, Roman D, Wagnerova, Alexandra, Lindenmeyer, Maja T, Cohen, Clemens D, Strnad, Pavel, Goumenos, Dimitrios S, Floege, Jürgen, Boor, Peter

“…Keratins, the intermediate filaments of the epithelial cell cytoskeleton, are up-regulated and post-translationally modified in stress situations. Renal…”
Get more information

Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts by Shved, Natallia, Warsow, Gregor, Eichinger, Felix, Hoogewijs, David, Brandt, Simone, Wild, Peter, Kretzler, Matthias, Cohen, Clemens D., Lindenmeyer, Maja T.

“…Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional mechanisms is involved in development of chronic kidney diseases (CKD)…”
Get full text

Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus by Kahlenberg, J Michelle, Thacker, Seth G, Berthier, Celine C, Cohen, Clemens D, Kretzler, Matthias, Kaplan, Mariana J

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations including severe organ damage and vascular dysfunction leading to…”
Get full text

Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes by Lei, Yutian, Devarapu, Satish K, Motrapu, Manga, Cohen, Clemens D, Lindenmeyer, Maja T, Moll, Solange, Kumar, Santhosh V, Anders, Hans-Joachim

“…Inflammasome-driven release of interleukin(IL)-1β is a central element of many forms of sterile inflammation and has been evident to promote the onset and…”
Get full text

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice by Hartleben, Björn, Gödel, Markus, Meyer-Schwesinger, Catherine, Liu, Shuya, Ulrich, Theresa, Köbler, Sven, Wiech, Thorsten, Grahammer, Florian, Arnold, Sebastian J, Lindenmeyer, Maja T, Cohen, Clemens D, Pavenstädt, Hermann, Kerjaschki, Dontscho, Mizushima, Noboru, Shaw, Andrey S, Walz, Gerd, Huber, Tobias B

“…Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The postmitotic podocyte is the primary glomerular target for toxic,…”
Get full text

Targeting mTOR Signaling Can Prevent the Progression of FSGS by Zschiedrich, Stefan, Bork, Tillmann, Liang, Wei, Wanner, Nicola, Eulenbruch, Kristina, Munder, Stefan, Hartleben, Björn, Kretz, Oliver, Gerber, Simon, Simons, Matias, Viau, Amandine, Burtin, Martine, Wei, Changli, Reiser, Jochen, Herbach, Nadja, Rastaldi, Maria-Pia, Cohen, Clemens D, Tharaux, Pierre-Louis, Terzi, Fabiola, Walz, Gerd, Gödel, Markus, Huber, Tobias B

“…Mammalian target of rapamycin (mTOR) signaling is involved in a variety of kidney diseases. Clinical trials administering mTOR inhibitors to patients with…”
Get full text

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy by Liu, Shuya, Zhao, Yu, Lu, Shun, Zhang, Tianran, Lindenmeyer, Maja T, Nair, Viji, Gies, Sydney E, Wu, Guochao, Nelson, Robert G, Czogalla, Jan, Aypek, Hande, Zielinski, Stephanie, Liao, Zhouning, Schaper, Melanie, Fermin, Damian, Cohen, Clemens D, Delic, Denis, Krebs, Christian F, Grahammer, Florian, Wiech, Thorsten, Kretzler, Matthias, Meyer-Schwesinger, Catherine, Bonn, Stefan, Huber, Tobias B

“…Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations…”
Get full text

Fibronectin is up‐regulated in podocytes by mechanical stress by Kliewe, Felix, Kaling, Sören, Lötzsch, Henriette, Artelt, Nadine, Schindler, Maximilian, Rogge, Henrik, Schröder, Sindy, Scharf, Christian, Amann, Kerstin, Daniel, Christoph, Lindenmeyer, Maja T., Cohen, Clemens D., Endlich, Karlhans, Endlich, Nicole

“…Hypertension is one of the central causes of kidney damage. In the past it was shown that glomerular hypertension leads to morphologic changes of podocytes and…”
Get full text

Integrative biology identifies shared transcriptional networks in CKD by Martini, Sebastian, Nair, Viji, Keller, Benjamin J, Eichinger, Felix, Hawkins, Jennifer J, Randolph, Ann, Böger, Carsten A, Gadegbeku, Crystal A, Fox, Caroline S, Cohen, Clemens D, Kretzler, Matthias

“…A previous meta-analysis of genome-wide association data by the Cohorts for Heart and Aging Research in Genomic Epidemiology and CKDGen consortia identified 16…”
Get full text

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs by Solagna, Francesca, Tezze, Caterina, Lindenmeyer, Maja T, Lu, Shun, Wu, Guochao, Liu, Shuya, Zhao, Yu, Mitchell, Robert, Meyer, Charlotte, Omairi, Saleh, Kilic, Temel, Paolini, Andrea, Ritvos, Olli, Pasternack, Arja, Matsakas, Antonios, Kylies, Dominik, Wiesch, Julian Schulze Zur, Turner, Jan-Eric, Wanner, Nicola, Nair, Viji, Eichinger, Felix, Menon, Rajasree, Martin, Ina V, Klinkhammer, Barbara M, Hoxha, Elion, Cohen, Clemens D, Tharaux, Pierre-Louis, Boor, Peter, Ostendorf, Tammo, Kretzler, Matthias, Sandri, Marco, Kretz, Oliver, Puelles, Victor G, Patel, Ketan, Huber, Tobias B

“…Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between…”
Get full text

Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset by Lindenmeyer, Maja T, Eichinger, Felix, Sen, Kontheari, Anders, Hans-Joachim, Edenhofer, Ilka, Mattinzoli, Deborah, Kretzler, Matthias, Rastaldi, Maria P, Cohen, Clemens D

“…Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular…”
Get full text

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis by Buhl, Eva M, Djudjaj, Sonja, Klinkhammer, Barbara M, Ermert, Katja, Puelles, Victor G, Lindenmeyer, Maja T, Cohen, Clemens D, He, Chaoyong, Borkham‐Kamphorst, Erawan, Weiskirchen, Ralf, Denecke, Bernd, Trairatphisan, Panuwat, Saez‐Rodriguez, Julio, Huber, Tobias B, Olson, Lorin E, Floege, Jürgen, Boor, Peter

“…Kidney fibrosis is characterized by expansion and activation of platelet‐derived growth factor receptor‐β (PDGFR‐β)‐positive mesenchymal cells. To study the…”
Get full text

Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74 by Djudjaj, Sonja, Lue, Hongqi, Rong, Song, Papasotiriou, Marios, Klinkhammer, Barbara M, Zok, Stephanie, Klaener, Ole, Braun, Gerald S, Lindenmeyer, Maja T, Cohen, Clemens D, Bucala, Richard, Tittel, Andre P, Kurts, Christian, Moeller, Marcus J, Floege, Juergen, Ostendorf, Tammo, Bernhagen, Jürgen, Boor, Peter

“…Pathologic proliferation of mesangial and parietal epithelial cells (PECs) is a hallmark of various glomerulonephritides. Macrophage migration inhibitory…”
Get full text

Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice by Abed, Ahmed, Leroyer, Aurélie S., Kavvadas, Panagiotis, Authier, Florence, Bachelier, Richard, Foucault-Bertaud, Alexandrine, Bardin, Nathalie, Cohen, Clemens D., Lindenmeyer, Maja T., Genest, Magali, Joshkon, Ahmad, Jourde-Chiche, Noémie, Burtey, Stéphane, Blot-Chabaud, Marcel, Dignat-George, Françoise, Chadjichristos, Christos E.

“…CD146 is an endothelial junctional adhesion molecule, which expression is increased in human glomerular diseases. However, the pathological significance of…”
Get full text