Search Results - "Cohen, A F"

Towards remote monitoring in pediatric care and clinical trials-Tolerability, repeatability and reference values of candidate digital endpoints derived from physical activity, heart rate and sleep in healthy children by Kruizinga, M D, Heide, N van der, Moll, A, Zhuparris, A, Yavuz, Y, Kam, M L de, Stuurman, F E, Cohen, A F, Driessen, G J A

“…Digital devices and wearables allow for the measurement of a wide range of health-related parameters in a non-invasive manner, which may be particularly…”
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Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients by van Meir, H., Nout, R. A., Welters, M. J. P., Loof, N. M., de Kam, M. L., van Ham, J. J., Samuels, S., Kenter, G. G., Cohen, A. F., Melief, C. J. M., Burggraaf, J., van Poelgeest, M. I. E., van der Burg, S. H.

“…New treatments based on combinations of standard therapeutic modalities and immunotherapy are of potential use, but require a profound understanding of immune…”
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Establishing risk of human experimentation with drugs: lessons from TGN1412 by Kenter, MJH, Cohen, AF

“…Additionally, several clinical studies of antibodies against the T-cell CD3 antigen have been done, in which massive systemic release of several cytokines and…”
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Effect of intrapulmonary tetrahydrocannabinol administration in humans by Zuurman, L., Roy, C., Schoemaker, RC, Hazekamp, A., den Hartigh, J., Bender, JCME, Verpoorte, R., Pinquier, JL, Cohen, AF, van Gerven, JMA

“…This randomised, double-blind, placebo-controlled, cross-over study was designed to identify which pharmacodynamic parameters most accurately quantify the…”
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Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects by de Haas, SL, Schoemaker, RC, van Gerven, JMA, Hoever, P, Cohen, AF, Dingemanse, J

“…Zolpidem is one of the most frequently prescribed hypnotics, as it is a very short-acting compound with relatively few side effects. Zolpidem’s short duration…”
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Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects by Dumont, G. J. H., De Visser, S. J., Cohen, A. F., Van Gerven, J. M. A.

“…Aims Studies of novel centrally acting drugs in healthy volunteers are traditionally concerned with kinetics and tolerability, but useful information may also…”
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Pharmacokinetics and systemic endocrine effects of the phyto‐oestrogen 8‐prenylnaringenin after single oral doses to postmenopausal women by Rad, M., Hümpel, M., Schaefer, O., Schoemaker, R. C., Schleuning, W‐D., Cohen, A. F., Burggraaf, J.

“…Aims Pre‐clinical data suggest that the racemic phyto‐oestrogen 8‐prenylnaringenin (8‐PN) may have beneficial effects in postmenopausal women and may become an…”
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Modelling of the concentration—effect relationship of THC on central nervous system parameters and heart rate — insight into its mechanisms of action and a tool for clinical research and development of cannabinoids by Strougo, A., Zuurman, L., Roy, C., Pinquier, JL, van Gerven, JMA, Cohen, AF, Schoemaker, RC

“…Pharmacokinetics after pulmonary administration of δ-9-tetrahydrocannabinol (THC) and its major metabolites 11-OH-THC and 11-nor-9-COOH-THC was quantified…”
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Re-engineering the European Union Clinical Trials Directive by Kenter, MJH, Cohen, AF

“…In Europe, non-drug trials are reviewed only by RECs. Since the regulation of these bodies is the exclusive responsibility of member states, the organisation…”
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The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects by Liem-Moolenaar, M, Zoethout, RWM, de Boer, P, Schmidt, M, de Kam, ML, Cohen, AF, Franson, KL, van Gerven, JMA

“…In this study the effects of R213129, a selective glycine transporter 1 inhibitor, on central nervous system function were investigated in healthy males in the…”
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Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625 by Zuurman, L., Roy, C., Schoemaker, RC, Amatsaleh, A., Guimaeres, L., Pinquier, JL, Cohen, AF, van Gerven, JMA

“…CB1 antagonists such as AVE1625 are potentially useful in the treatment of obesity, smoking cessation and cognitive impairment. Proof of pharmacological action…”
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Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol by Liem-Moolenaar, M., Gray, FA, de Visser, SJ, Franson, KL, Schoemaker, RC, Schmitt, JAJ, Cohen, AF, van Gerven, JMA

“…Central Nervous System (CNS) effects of talnetant, an NK-3 antagonist in development for schizophrenia, were compared to those of haloperidol and placebo. The…”
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Biomarkers for the effects of benzodiazepines in healthy volunteers by De Visser, S. J., Van Der Post, J. P., De Waal, P. P., Cornet, F., Cohen, A. F., Van Gerven, J. M. A.

“…Studies of novel centrally acting drugs in healthy volunteers are traditionally concerned with kinetics and tolerability, but useful information may also be…”
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The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects by Liem-Moolenaar, M, Zoethout, RWM, de Boer, P, Schmidt, M, de Kam, ML, Cohen, AF, Franson, KL, van Gerven, JMA

“…The effects of the selective inhibitor of the glycine transporter 1, R231857, in development for schizophrenia, on the central nervous system (CNS) were…”
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The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol by Zoethout, RWM, Iannone, R, Bloem, BR, Palcza, J, Murphy, G, Chodakewitz, J, Buntinx, A, Gottesdiener, K, Marsilio, S, Rosen, L, van Dyck, K, Louis, ED, Cohen, AF, Schoemaker, RC, Tokita, S, Sato, N, Koblan, KS, Hargreaves, RH, Renger, JJ, van Gerven, JMA

“…Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the…”
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The central nervous system effects, pharmacokinetics and safety of the NAALADase‐inhibitor GPI 5693 by Van Der Post, J. P., De Visser, S. J., De Kam, M. L., Woelfler, M., Hilt, D. C., Vornov, J., Burak, E. S., Bortey, E., Slusher, B. S., Limsakun, T., Cohen, A. F., Van Gerven, J. M. A.

“…Aim The aim was to assess the central nervous system (CNS) effects, pharmacokinetics and safety of GPI 5693, an inhibitor of a novel CNS‐drug target, NAALADase…”
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The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers by de Haas, SL, Franson, KL, Schmitt, JAJ, Cohen, AF, Fau, JB, Dubruc, C, van Gerven, JMA

“…Abstract Benzodiazepines are effective short-term treatments for anxiety disorders, but their use is limited by undesirable side effects related to Central…”
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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation by Kruizinga, M D, Stuurman, F E, Exadaktylos, V, Doll, R J, Stephenson, D T, Groeneveld, G J, Driessen, G J A, Cohen, A F

“…Novel digital endpoints gathered via wearables, small devices, or algorithms hold great promise for clinical trials. However, implementation has been slow…”
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Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans by Liem‐Moolenaar, M, Cerneus, D, Molloy, CJ, End, D, Brown, KH, Kam, ML, Cohen, AF, Hensbergen, Y, Burggraaf, J

“…RWJ‐800088 is a novel thrombopoietin mimetic peptide for the treatment of thrombocytopenia. The objectives of this study were to evaluate the pharmacokinetics,…”
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Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers by Zuurman, L, Passier, PCCM, de Kam, ML, Kleijn, HJ, Cohen, AF, van Gerven, JMA

“…Abstract CB1/CB2 agonists are reported to have sedative, amnestic, analgesic and anti-emetic properties, which would make them ideal drugs for outpatient…”
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