Search Results - "Cognata, Valentina"

The contribution of CNVs to the most common aging-related neurodegenerative diseases by Gentile, Giulia, La Cognata, Valentina, Cavallaro, Sebastiano

“…Alzheimer and Parkinson’s diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic…”
Get full text

Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase‐activating polypeptide in an in vitro model of amyotrophic lateral sclerosis by Maugeri, Grazia, D’Amico, Agata G., Rasà, Daniela M., Federico, Concetta, Saccone, Salvatore, Morello, Giovanna, Cognata, Valentina, Cavallaro, Sebastiano, D’Agata, Velia

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. Based on transcriptional…”
Get full text

iPSCs: A Preclinical Drug Research Tool for Neurological Disorders by Bonaventura, Gabriele, Iemmolo, Rosario, Attaguile, Giuseppe Antonino, La Cognata, Valentina, Pistone, Brigida Sabrina, Raudino, Giuseppe, D'Agata, Velia, Cantarella, Giuseppina, Barcellona, Maria Luisa, Cavallaro, Sebastiano

“…The development and commercialization of new drugs is an articulated, lengthy, and very expensive process that proceeds through several steps, starting from…”
Get full text

Dental mesenchymal stem cells and neuro-regeneration: a focus on spinal cord injury by Bonaventura, Gabriele, Incontro, Salvatore, Iemmolo, Rosario, La Cognata, Valentina, Barbagallo, Ignazio, Costanzo, Erminio, Barcellona, Maria Luisa, Pellitteri, Rosalia, Cavallaro, Sebastiano

“…Regenerative medicine is a branch of translational research that aims to reestablish irreparably damaged tissues and organs by stimulating the body’s own…”
Get full text

Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema by Maugeri, Grazia, D'Amico, Agata Grazia, Rasà, Daniela Maria, La Cognata, Valentina, Saccone, Salvatore, Federico, Concetta, Cavallaro, Sebastiano, D'Agata, Velia

“…More than 1 billion world's population actively smokes tobacco containing the bioactive component nicotine (NT). The biological role of this molecule is…”
Get full text

Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative Diseases by La Cognata, Valentina, Morello, Giovanna, Cavallaro, Sebastiano

“…Molecular and clinical heterogeneity is increasingly recognized as a common characteristic of neurodegenerative diseases (NDs), such as Alzheimer’s disease,…”
Get full text

Highlights on Genomics Applications for Lysosomal Storage Diseases by La Cognata, Valentina, Guarnaccia, Maria, Polizzi, Agata, Ruggieri, Martino, Cavallaro, Sebastiano

“…Lysosomal storage diseases (LSDs) are a heterogeneous group of rare multisystem genetic disorders occurring mostly in infancy and childhood, characterized by a…”
Get full text

A Targeted Next-Generation Sequencing Panel to Genotype Gliomas by Guarnaccia, Maria, Guarnaccia, Laura, La Cognata, Valentina, Navone, Stefania, Campanella, Rolando, Ampollini, Antonella, Locatelli, Marco, Miozzo, Monica, Marfia, Giovanni, Cavallaro, Sebastiano

“…Gliomas account for the majority of primary brain tumors. Glioblastoma is the most common and malignant type. Based on their extreme molecular heterogeneity,…”
Get full text

Protective Role of Eicosapentaenoic and Docosahexaenoic and Their N -Ethanolamide Derivatives in Olfactory Glial Cells Affected by Lipopolysaccharide-Induced Neuroinflammation by Pellitteri, Rosalia, La Cognata, Valentina, Russo, Cristina, Patti, Angela, Sanfilippo, Claudia

“…Neuroinflammation is a symptom of different neurodegenerative diseases, and growing interest is directed towards active drug development for the reduction of…”
Get full text

A Comprehensive, Targeted NGS Approach to Assessing Molecular Diagnosis of Lysosomal Storage Diseases by La Cognata, Valentina, Cavallaro, Sebastiano

“…With over 60 different disorders and a combined incidence occurring in 1:5000-7000 live births, lysosomal storage diseases (LSDs) represent a major public…”
Get full text

Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases by Gentile, Giulia, Morello, Giovanna, La Cognata, Valentina, Guarnaccia, Maria, Conforti, Francesca Luisa, Cavallaro, Sebastiano

“…Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic Lateral Sclerosis (ALS) are representative neurodegenerative diseases (NDs) characterized…”
Get full text

Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene by La Cognata, Valentina, Iemmolo, Rosario, D'Agata, Velia, Scuderi, Soraya, Drago, Filippo, Zappia, Mario, Cavallaro, Sebastiano

“…The completion of the Human Genome Project aroused renewed interest in alternative splicing, an efficient and widespread mechanism that generates multiple…”
Get full text

Design and Validation of a Custom NGS Panel Targeting a Set of Lysosomal Storage Diseases Candidate for NBS Applications by La Cognata, Valentina, Guarnaccia, Maria, Morello, Giovanna, Ruggieri, Martino, Polizzi, Agata, Cavallaro, Sebastiano

“…Lysosomal storage diseases (LSDs) are a heterogeneous group of approximately 70 monogenic metabolic disorders whose diagnosis represents an arduous challenge…”
Get full text

NAP counteracts hyperglycemia/hypoxia induced retinal pigment epithelial barrier breakdown through modulation of HIFs and VEGF expression by D'Amico, Agata G., Maugeri, Grazia, Rasà, Daniela M., La Cognata, Valentina, Saccone, Salvatore, Federico, Concetta, Cavallaro, Sebastiano, D'Agata, Velia

“…Diabetic macular edema (DME) is a common complication leading to a central vision loss in patients with diabetes. In this eye pathology, the…”
Get full text

Detection of Structural Variants by NGS: Revealing Missing Alleles in Lysosomal Storage Diseases by La Cognata, Valentina, Cavallaro, Sebastiano

“…Lysosomal storage diseases (LSDs) are a heterogeneous group of rare multisystem metabolic disorders occurring mostly in infancy and childhood, characterized by…”
Get full text

Alternative Splicing of ALS Genes: Misregulation and Potential Therapies by Perrone, Benedetta, La Cognata, Valentina, Sprovieri, Teresa, Ungaro, Carmine, Conforti, Francesca Luisa, Andò, Sebastiano, Cavallaro, Sebastiano

“…Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), Parkinson’s, Alzheimer’s, and Huntington’s disease…”
Get full text

Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach by Morello, Giovanna, Guarnaccia, Maria, Spampinato, Antonio Gianmaria, La Cognata, Valentina, D’Agata, Velia, Cavallaro, Sebastiano

“…Amyotrophic lateral sclerosis (ALS) is a devastating and still untreatable motor neuron disease. Despite the molecular mechanisms underlying ALS pathogenesis…”
Get full text

CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice by La Cognata, Valentina, Golini, Elisabetta, Iemmolo, Rosario, Balletta, Sara, Morello, Giovanna, De Rosa, Carla, Villari, Ambra, Marinelli, Sara, Vacca, Valentina, Bonaventura, Gabriele, Dell'Albani, Paola, Aronica, Eleonora, Mammano, Fabio, Mandillo, Silvia, Cavallaro, Sebastiano

“…Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by depletion of motor neurons (MNs), for which effective medical…”
Get full text

Biocompatibility between Silicon or Silicon Carbide surface and Neural Stem Cells by Bonaventura, Gabriele, Iemmolo, Rosario, La Cognata, Valentina, Zimbone, Massimo, La Via, Francesco, Fragalà, Maria Elena, Barcellona, Maria Luisa, Pellitteri, Rosalia, Cavallaro, Sebastiano

“…Silicon has been widely used as a material for microelectronic for more than 60 years, attracting considerable scientific interest as a promising tool for the…”
Get full text

Differential expression of PARK2 splice isoforms in an in vitro model of dopaminergic‐like neurons exposed to toxic insults mimicking Parkinson's disease by La Cognata, Valentina, Maugeri, Grazia, D'Amico, Agata Grazia, Saccone, Salvatore, Federico, Concetta, Cavallaro, Sebastiano, D'Agata, Velia

“…Mutations in PARK2 (or parkin) are responsible for 50% of cases of autosomal‐recessive juvenile‐onset Parkinson's disease (PD). To date, 21 alternative splice…”
Get full text