Search Results - "Coggins, J. R."

Evidence for the shikimate pathway in apicomplexan parasites by McLeod, Rima, Roberts, Fiona, Roberts, Craig W, Johnson, Jennifer J, Kyle, Dennis E, Krell, Tino, Coggins, John R, Coombs, Graham H, Milhous, Wilbur K, Tzipori, Saul, Ferguson, David J. P, Chakrabarti, Debopam

“…Parasites of the phylum Apicomplexa cause substantial morbidity, mortality and economic losses, and new medicines to treat them are needed urgently,. The…”
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A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation by Campbell, S.A., Richards, T.A., Mui, E.J., Samuel, B.U., Coggins, J.R., McLeod, R., Roberts, C.W.

“…The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is…”
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Modeling the relationship between habitat preferences and home-range size: a case study on a large mobile colubrid snake from North America by Kapfer, J. M., Pekar, C. W., Reineke, D. M., Coggins, J. R., Hay, R.

“…Effective wildlife conservation plans should consider both the habitat needs and spatial requirements of the species in question. Studies that focus on the…”
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Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa by Walker, G.E, Dunbar, B, Hunter, I.S, Nimmo, H.G, Coggins, J.R

“…The tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthases from Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora…”
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A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes by KLEANTHOUS, C, DEKA, R, DAVIS, K, KELLY, S. M, COOPER, A, HARDING, S. E, PRICE, N. C, HAWKINS, A. R, COGGINS, J. R

“…This paper compares the biophysical and mechanistic properties of a typical type I dehydroquinase (DHQase), from the biosynthetic shikimate pathway of…”
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A low-complexity intracardiac electrogram compression algorithm by Coggins, R.J., Jabri, M.A.

“…Implantable cardioverter defibrillators (ICD's) detect, diagnose and treat the potentially fatal heart arrhythmias known as bradycardia, ventricular…”
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Experiences with the shikimate-pathway enzymes as targets for rational drug design by Coggins, J R, Abell, C, Evans, L B, Frederickson, M, Robinson, D A, Roszak, A W, Lapthorn, A P

“…The background and current context of work on the shikimate-pathway enzymes as potential targets for anti-bacterial, anti-fungal and anti-parasitic drugs is…”
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Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases by SUBHENDU CHAUDHURI, DUNCAN, K, GRAHAM, L. D, COGGINS, J. R

“…The lysine residues involved in Schiff-base formation at the active sites of both the 3-dehydroquinase component of the pentafunctional arom enzyme of…”
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Synthesis of 2-Bromo- and 2-Fluoro-3-dehydroshikimic Acids and 2-Bromo- and 2-Fluoroshikimic Acids Using Synthetic and Enzymatic Approaches by González-Bello, C, Manthey, M. K, Harris, J. H, Hawkins, A. R, Coggins, J. R, Abell, C

“…The syntheses of 2-bromo-3-dehydroshikimic acid1 (5) and 2-bromoshikimic acid2 (8), are described. Their formation from (2R)-2-bromo-3-dehydroquinic acid (2)…”
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Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase by DEKA, R. K, KLEANTHOUS, C, COGGINS, J. R

“…The shikimate pathway enzyme 3-dehydroquinase is very susceptible to inactivation by the group-specific reagent diethyl pyrocarbonate (DEP). Inactivation…”
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Characterization of the type I dehydroquinase from Salmonella typhi by MOORE, J. D, HAWKINS, A. R, CHARLES, I. G, DEKA, R, COGGINS, J. R, COOPER, A, KELLY, S. M, PRICE, N. C

“…The type I dehydroquinase from the human pathogen Salmonella typhi was overexpressed in an Escherichia coli host and purified to homogeneity. The S. typhi…”
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Reversible alkylation of an active site methionine residue in dehydroquinase by KLEANTHOUS, C, COGGINS, J. R

“…Iodoacetic acid inactivates dehydroquinase by simultaneously alkylating 2 methionine residues (Met-23 and Met-205), presumed to be active site residues…”
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Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase by Anton, I A, Coggins, J R

“…The Escherichia coli aroE gene encoding shikimate dehydrogenase was sequenced. The deduced amino acid sequence was confirmed by N-terminal amino acid…”
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Efficient independent activity of a monomeric, monofunctional dehydroquinate synthase derived from the N-terminus of the pentafunctional AROM protein of Aspergillus nidulans by Moore, J.D, Coggins, J.R, Virden, R, Hawkins, A.R

“…The dehydroquinate synthase (DHQ synthase) functional domain from the pentafunctional AROM protein of Aspergillus nidulans has previously been overproduced in…”
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The purification of shikimate dehydrogenase from Escherichia coli by Chaudhuri, S, Coggins, J R

“…A procedure was developed for the purification of shikimate dehydrogenase from Escherichia coli. Homogeneous enzyme with specific activity 1100 units/mg of…”
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Environmental, behavioral, and habitat variables influencing body temperature in radio-tagged bullsnakes, Pituophis catenifer sayi by Kapfer, J.M., Pauers, M.J., Reineke, D.M., Coggins, J.R., Hay, R.

“…Studies regarding the thermal ecology of snakes are important to understanding their life histories. Yet, little is known about the thermal ecology of the…”
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Chorismate synthase from Staphylococcus aureus by Horsburgh, Malcolm J, Foster, Timothy J, Barth, Peter T, Coggins, John R

“…1 Division of Biochemistry & Molecular Biology, Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK 2 Microbiology Department,…”
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The cloning and expression of the aroL gene from Escherichia coli K12. Purification and complete amino acid sequence of shikimate kinase II, the aroL-gene product by Millar, G, Lewendon, A, Hunter, M G, Coggins, J R

“…The aroL gene encoding the enzyme shikimate kinase II was cloned from Escherichia coli K12. Construction of over-expressing strains permitted for the first…”
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The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase by Duncan, K, Chaudhuri, S, Campbell, M S, Coggins, J R

“…The enzyme 3-dehydroquinase was purified in milligram quantities from an overproducing strain of Escherichia coli. The amino acid sequence was deduced from the…”
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Stabilization of the shikimate pathway enzyme dehydroquinase by covalently bound ligand by KLEANTHOUS, C, REILLY, M, COOPER, A, KELLY, S, PRICE, N. C, COGGINS, J. R

“…Reversible binding of a ligand to an enzyme active site can elicit a variety of changes in the protein, such as conformational changes (close to the site of…”
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