Search Results - "Cogburn, J. N."

Selective Cyclooxygenase-2 Inhibitors:  Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents by Khanna, Ish K, Yu, Yi, Huff, Renee M, Weier, Richard M, Xu, Xiangdong, Koszyk, Francis J, Collins, Paul W, Cogburn, J. Nita, Isakson, Peter C, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Yuan, Jinhua, Yang, Dai-Chang, Zhang, Yan Y

“…A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000−9000-fold) inhibitors of the human…”
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Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats by PAULSON, S. K, ZHANG, J. Y, MAZIASZ, T. J, SCHOENHARD, G. L, BURTON, E. G, BREAU, A. P, HRIBAR, J. D, LIU, N. W. K, JESSEN, S. M, LAWAL, Y. M, COGBURN, J. N, GRESK, C. J, MARKOS, C. S

“…The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H -pyrazol-1-yl]…”
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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib) by Penning, Thomas D, Talley, John J, Bertenshaw, Stephen R, Carter, Jeffery S, Collins, Paul W, Docter, Stephen, Graneto, Matthew J, Lee, Len F, Malecha, James W, Miyashiro, Julie M, Rogers, Roland S, Rogier, D. J, Yu, Stella S, Anderson, Gary D, Burton, Earl G, Cogburn, J. Nita, Gregory, Susan A, Koboldt, Carol M, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Zhang, Yan Y, Isakson, Peter C

“…A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and…”
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Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors:  Synthesis and Structure−Activity Relationships by Huang, Horng-Chih, Li, James J, Garland, Danny J, Chamberlain, Timothy S, Reinhard, Emily J, Manning, Robert E, Seibert, Karen, Koboldt, Carol M, Gregory, Susan A, Anderson, Gary D, Veenhuizen, Amy W, Zhang, Yan, Perkins, William E, Burton, Earl G, Cogburn, J. Nita, Isakson, Peter C, Reitz, David B

“…A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of…”
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Sulphation of proteochondroitin and 4-methylumbelliferyl β-D-xyloside-chondroitin formed by mouse mastocytoma cells cultured in sulphate-deficient medium by SILBERT, J. E, GEETHA SUGUMARAN, COGBURN, J. N

“…Mouse mastocytoma cells were cultured in medium containing [3H]GlcN and concentrations of [35S]sulphate varying from 0.01 to 0.5 mM. Intracellular…”
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Simultaneous sulfation of endogenous chondroitin sulfate and chondroitin-derived oligosaccharides. Studies with separate 4-sulfating and 6-sulfating microsomal systems by Sugumaran, G, Cogburn, J N, Silbert, J E

“…Microsomal preparations from chondroitin 6-sulfate-producing chick embryo epiphyseal cartilage and from chondroitin 4-sulfate-producing mouse mastocytoma cells…”
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The effect of penultimate N-acetylgalactosamine 4-sulfate on chondroitin chain elongation by Cogburn, J N, Silbert, J E

“…Previous work has shown that odd-numbered oligosaccharides containing nonreducing terminal, non-sulfated N-acetylgalactosamine (GalNAc) or 6-sulfated GalNAc…”
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A model of human small intestinal absorptive cells. 1. Transport barrier by Cogburn, J N, Donovan, M G, Schasteen, C S

“…The Caco-2 cell culture model of human small intestinal absorptive cells was used to investigate transepithelial transport. Transport of permeability markers…”
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib) by Penning, T D, Talley, J J, Bertenshaw, S R, Carter, J S, Collins, P W, Docter, S, Graneto, M J, Lee, L F, Malecha, J W, Miyashiro, J M, Rogers, R S, Rogier, D J, Yu, S S, AndersonGD, Burton, E G, Cogburn, J N, Gregory, S A, Koboldt, C M, Perkins, W E, Seibert, K, Veenhuizen, A W, Zhang, Y Y, Isakson, P C

“…A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and…”
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1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents by Li, James J, Anderson, Gary D, Burton, Earl G, Cogburn, J. Nita, Collins, Joe T, Garland, Danny J, Gregory, Susan A, Huang, Horng-Chih, Isakson, Peter C

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Increased proteoglycan synthesis following the differentiation of F9 embryonal carcinoma cells: formation of a differentiation-specific proteoheparan sulfate by Baldwin, C T, Silbert, J E, Humphries, D E, Cogburn, J N, Smith, B D

“…We have examined changes in proteoglycan synthesis by F9 embryonal carcinoma cells after the cells have been treated with retinoic acid or retinoic acid plus…”
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A model of human small intestinal absorptive cells. I : Transport Barrier by COGBURN, J. N, DONOVAN, M. G, SCHASTEEN, C. S

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1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents by Li, J J, Anderson, G D, Burton, E G, Cogburn, J N, Collins, J T, Garland, D J, Gregory, S A, Huang, H C, Isakson, P C, Koboldt, C M

“…A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors…”
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Physiological and cytotoxic effects of Ca(2+) ionophores on Caco-2 paracellular permeability: relationship of 45Ca(2+) efflux to 51 Cr release by Rutten, M J, Cogburn, J N, Schasteen, C S, Solomon, T

“…The human intestinal cell line, Caco-2, and the Ca2+ ionophores, A23187 and ionomycin, were used to determine the interrelationships of 45Ca(2+) efflux,…”
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Location of carrageenan and incorporation of 35SO 4 2? into sulfur amino acids in the red alga Chondrus crispus by Tveter-Gallagherl, E., Cogburn, J. N., Mathieson, A. C., Schiff, J. A.

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