T-lymphocytopaenia, opportunistic infections and pathological findings in Ghanaian AIDS patients and their sexual partners

Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocy...

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Bibliographic Details
Published in:	East African medical journal Vol. 74; no. 12; p. 784
Main Authors:	Ayisi, N K, Wiredu, E K, Sata, T, Nyadedzor, C, Tsiagbe, V K, Newman, M, Cofie, C N, Taneguchi, K
Format:	Journal Article
Language:	English
Published:	Kenya 01-12-1997
Subjects:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - immunology Adult AIDS-Related Opportunistic Infections - pathology Apoptosis Case-Control Studies Cause of Death CD4-CD8 Ratio Child Female Ghana HIV-1 HIV-2 Humans Lymphopenia - virology Male Sexual Partners T-Lymphocytes Ghana Organization And Administration Respiratory Infections Viral Diseases Infections English Speaking Africa Acquired Immunodeficiency Syndrome Population Research Report Behavior Program Activities Demographic Factors Programs Mortality Africa Ghana Hiv Infections Clients Causes Of Death Diseases Western Africa Signs And Symptoms Developing Countries Africa South Of The Sahara Sex Behavior Sexual Partners Population Dynamics
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Summary:	Ninety-nine patients at Center for Disease Control (CDC) clinical stage IV were studied. Twelve (12.12%) of these patients turned out to be HIV seronegative. Ten out of the 12 HIV negative patients were immunocompetent whereas the other two had proportional decreases in both CD4+ and CD8+ T-lymphocytes. HIV-1, HIV-2, and dual infection, were detected in 51.5%, 2%, and 22.2% respectively of clinical AIDS patients. The other 12.12% of clinical AIDS patients were indeterminate for HIV antibodies. All HIV positive patients with the exception of two, were immunocompromised with respect to CD4+ and CD8+ T-lymphocyte counts. Two healthy spouses and three children of patients who died from the disease were seronegative for HIV antibodies. Herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV) antibody titres were higher in HIV infected than uninfected blood. Patients with chronic diarrhoea, lymphadenopathy, pneumonia, and tuberculosis, either alone or in combination of two or more of such symptoms, were found to be more likely to be confirmed by serology and immunology as definitive AIDS patients in Ghana. In postmortem studies on 20 patients, pneumonia due to tuberculosis constituted the major cause of death. Toxoplasmosis, cytomegaloviral eosophagitis and enteritis, and cryptococcosis were the major opportunistic infections detected. Programmed cell death (apoptosis) was found by the DNA gel electrophoresis method to be an unlikely major mechanism of accelerated culture induced death of PBMCs from CDC stage IV AIDS patients.
ISSN:	0012-835X