Search Results - "Coffman, RL"

INTERLEUKIN-10 AND THE INTERLEUKIN-10 RECEPTOR by Moore, Kevin W, de Waal Malefyt, Rene, Coffman, Robert L, O'Garra, Anne

“…Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a…”
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Origins of the T(H)1-T(H)2 model: a personal perspective by Coffman, Robert L

“…Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to…”
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Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses by MALAQUIAS, L. C. C., FALCÃO, P. L., SILVEIRA, A. M. S., GAZZINELLI, G., PRATA, A., COFFMAN, R. L., PIZZIOLO, V., SOUZA, C. P., COLLEY, D. G., CORREA‐OLIVEIRA, R.

“…The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble…”
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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus by Barrat, Franck J, Meeker, Thea, Gregorio, Josh, Chan, Jean H, Uematsu, Satoshi, Akira, Shizuo, Chang, Bonnie, Duramad, Omar, Coffman, Robert L

“…Raised serum levels of interferon (IFN)-alpha have been observed in systemic lupus erythematosus (SLE) patients, and these levels are correlated with both…”
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Role of transforming growth factor-beta in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B by Nagelkerken, L, Gollob, K J, Tielemans, M, Coffman, R L

“…Stimulation of murine CD4+ T cells with staphylococcal enterotoxin B (SEB) results in the preferential development of T helper (Th) 1 cells [i.e. high…”
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Comment on: Repositioning T H cell polarization from single cytokines to complex help by Jankovic, Dragana, Ciucci, Thomas, Coffman, Robert L, Coquet, Jonathan M, Le Gros, Graham, Mosmann, Tim R, Sher, Alan, Ronchese, Franca

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Comment on: Repositioning TH cell polarization from single cytokines to complex help by Jankovic, Dragana, Ciucci, Thomas, Coffman, Robert L., Coquet, Jonathan M., Le Gros, Graham, Mosmann, Tim R., Sher, Alan, Ronchese, Franca

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells by Fahlén, Linda, Read, Simon, Gorelik, Leonid, Hurst, Stephen D, Coffman, Robert L, Flavell, Richard A, Powrie, Fiona

“…CD4(+)CD25(+) regulatory T (T reg) cells play a pivotal role in control of the immune response. Transforming growth factor-beta (TGF-beta) has been shown to be…”
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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation by Asseman, C, Mauze, S, Leach, M W, Coffman, R L, Powrie, F

“…A T helper cell type 1-mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RB(high) CD4(+) T cells and can be prevented by…”
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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines by Barrat, Franck J, Cua, Daniel J, Boonstra, André, Richards, David F, Crain, Chad, Savelkoul, Huub F, de Waal-Malefyt, René, Coffman, Robert L, Hawrylowicz, Catherine M, O'Garra, Anne

“…We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro…”
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Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses by Yang, Kun, Puel, Anne, Zhang, Shenying, Eidenschenk, Céline, Ku, Cheng-Lung, Casrouge, Armanda, Picard, Capucine, von Bernuth, Horst, Senechal, Brigitte, Plancoulaine, Sabine, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Maródi, László, Davidson, Donald, Speert, David, Roifman, Chaim, Garty, Ben-Zion, Ozinsky, Adrian, Barrat, Franck J., Coffman, Robert L., Miller, Richard L., Li, Xiaoxia, Lebon, Pierre, Rodriguez-Gallego, Carlos, Chapel, Helen, Geissmann, Frédéric, Jouanguy, Emmanuelle, Casanova, Jean-Laurent

“…Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect…”
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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986 by Mosmann, Timothy R, Cherwinski, Holly, Bond, Martha W, Giedlin, Martin A, Coffman, Robert L

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New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25 by Hurst, Stephen D, Muchamuel, Tony, Gorman, Daniel M, Gilbert, Jonathan M, Clifford, Theresa, Kwan, Sylvia, Menon, Satish, Seymour, Brian, Jackson, Craig, Kung, Ted T, Brieland, Joan K, Zurawski, Sandra M, Chapman, Richard W, Zurawski, Gerard, Coffman, Robert L

“…We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches,…”
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Nonhuman primate models of asthma by Coffman, Robert L, Hessel, Edith M

“…Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms…”
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T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo by Cottrez, Francoise, Hurst, Steven D, Coffman, Robert L, Groux, Herve

“…We recently described a new population of CD4(+) regulatory T cells (Tr1) that inhibits proliferative responses of bystander T cells and prevents colitis…”
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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity by Friedberg, Jonathan W., Kim, Helen, McCauley, Mary, Hessel, Edith M., Sims, Paul, Fisher, David C., Nadler, Lee M., Coffman, Robert L., Freedman, Arnold S.

“…CpG oligodeoxynucleotides (CpG-ODNs) affect innate and adaptive immune responses, including antigen presentation, costimulatory molecule expression, dendritic…”
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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions by Marshall, Jason D., Fearon, Karen, Abbate, Christi, Subramanian, Sandhya, Yee, Priscilla, Gregorio, Josh, Coffman, Robert L., Van Nest, Gary

“…Recent reports have identified two major classes of CpG motif‐containing oligodeoxynucleotide immunostimulatory sequences (ISS): uniformly modified…”
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A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells by Powrie, F, Carlino, J, Leach, M W, Mauze, S, Coffman, R L

“…A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice…”
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Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction by Hessel, Edith M, Chu, Mabel, Lizcano, Jennifer O, Chang, Bonnie, Herman, Nancy, Kell, Sariah A, Wills-Karp, Marsha, Coffman, Robert L

“…A single treatment with a CpG-containing immunostimulatory DNA sequence (ISS) given before allergen challenge can inhibit T helper type 2 cell (Th2)-mediated…”
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Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy by MURRAY, Henry W, LU, Christina M, MAUZE, Smita, FREEMAN, Sherry, MOREIRA, Andre L, KAPLAN, Gilla, COFFMAN, Robert L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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