Search Results - "Coffman, Lan"

The double edge sword of fibrosis in cancer by Chandler, Chelsea, Liu, Tianshi, Buckanovich, Ronald, Coffman, Lan G.

“…Cancer-associated fibrosis is a critical component of the tumor microenvironment (TME) which significantly impacts cancer behavior. However, there is…”
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Serum ferritin: Past, present and future by Wang, Wei, Knovich, Mary Ann, Coffman, Lan G., Torti, Frank M., Torti, Suzy V.

“…Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron…”
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B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma by Ruffin, Ayana T., Cillo, Anthony R., Tabib, Tracy, Liu, Angen, Onkar, Sayali, Kunning, Sheryl R., Lampenfeld, Caleb, Atiya, Huda I., Abecassis, Irina, Kürten, Cornelius H. L., Qi, Zengbiao, Soose, Ryan, Duvvuri, Umamaheswar, Kim, Seungwon, Oesterrich, Steffi, Lafyatis, Robert, Coffman, Lan G., Ferris, Robert L., Vignali, Dario A. A., Bruno, Tullia C.

“…Current immunotherapy paradigms aim to reinvigorate CD8 + T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here,…”
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Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer by Brown, Jason R, Chan, Daniel K, Shank, Jessica J, Griffith, Kent A, Fan, Huihui, Szulawski, Robert, Yang, Kun, Reynolds, R Kevin, Johnston, Carolyn, McLean, Karen, Uppal, Shitanshu, Liu, J Rebecca, Cabrera, Lourdes, Taylor, Sarah E, Orr, Brian C, Modugno, Francesmary, Mehta, Pooja, Bregenzer, Michael, Mehta, Geeta, Shen, Hui, Coffman, Lan G, Buckanovich, Ronald J

“…BACKGROUNDEpidemiologic studies suggest that metformin has antitumor effects. Laboratory studies indicate metformin impacts cancer stem-like cells (CSCs). As…”
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Ovarian Carcinoma‐Associated Mesenchymal Stem Cells Arise from Tissue‐Specific Normal Stroma by Coffman, Lan G., Pearson, Alexander T., Frisbie, Leonard G., Freeman, Zachary, Christie, Elizabeth, Bowtell, David D., Buckanovich, Ronald J.

“…Carcinoma‐associated mesenchymal stem cells (CA‐MSCs) are critical stromal progenitor cells within the tumor microenvironment (TME). We previously demonstrated…”
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Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth by McLean, Karen, Tan, Lijun, Bolland, Danielle E., Coffman, Lan G., Peterson, Luke F., Talpaz, Moshe, Neamati, Nouri, Buckanovich, Ronald J.

“…Ovarian carcinoma-associated mesenchymal stem cells (CA-MSC) produce not only high levels of interleukin-6 (IL6) but also the related cytokine leukemia…”
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New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination by Coffman, Lan G, Burgos-Ojeda, Daniela, Wu, Rong, Cho, Kathleen, Bai, Shoumei, Buckanovich, Ronald J

“…Abstract Emerging evidence suggest that many high grade serous ‘ovarian’ cancers (HGSOC) start in the fallopian tube. Cancer cells are then recruited to the…”
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Ferritin for the clinician by Knovich, Mary Ann, Storey, Jonathan A, Coffman, Lan G, Torti, Suzy V, Torti, Frank M

“…Summary Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In…”
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Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop by Coffman, Lan G, Choi, Yun-Jung, McLean, Karen, Allen, Benjamin L, di Magliano, Marina Pasca, Buckanovich, Ronald J

“…The tumor microenvironment is critical to cancer growth and therapy resistance. We previously characterized human ovarian carcinoma-associated mesenchymal stem…”
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An Iron Regulatory Gene Signature Predicts Outcome in Breast Cancer by MILLER, Lance D, COFFMAN, Lan G, CHOU, Jeff W, BLACK, Michael A, BERGH, Jonas, D'AGOSTINO, Ralph, TORTI, Suzy V, TORTI, Frank M

“…Changes in iron regulation characterize the malignant state. However, the pathways that effect these changes and their specific impact on prognosis remain…”
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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer by Frisbie, Leonard, Pressimone, Catherine, Dyer, Emma, Baruwal, Roja, Garcia, Geyon, St. Croix, Claudette, Watkins, Simon, Calderone, Michael, Gorecki, Grace, Javed, Zaineb, Atiya, Huda I., Hempel, Nadine, Pearson, Alexander, Coffman, Lan G.

“…Ovarian cancer is characterized by early metastatic spread. This study demonstrates that carcinoma-associated mesenchymal stromal cells (CA-MSCs) enhance…”
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CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer by Iyengar, Mangala, O'Hayer, Patrick, Cole, Alex, Sebastian, Tara, Yang, Kun, Coffman, Lan, Buckanovich, Ronald J

“…High grade serous ovarian cancer (HGSOC) is a disease with a high relapse rate and poor overall survival despite good initial responses to platinum-based…”
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Call for action: expanding global access to hereditary cancer genetic testing by Bychkovsky, Brittany, Rana, Huma Q, Ademuyiwa, Foluso, Plichta, Jennifer, Anderson, Karen, Nogueira-Rodrigues, Angélica, Santa-Maria, Cesar A, Coffman, Lan G, Marquez, Carol, Das, Arunangshu, Taghian, Alphonse, Koeller, Diane R, Sandoval, Renata L, Park, Ben Ho, Dizon, Don S

“…Since the discovery of hereditary cancer genes in the 1990s, guidelines for germline testing have evolved from testing patients with specific cancer subtypes,…”
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Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2 by Choi, Yun-Jung, Ingram, Patrick N., Yang, Kun, Coffman, Lan, Iyengar, Mangala, Bai, Shoumei, Thomas, Dafydd G., Yoon, Euisik, Buckanovich, Ronald J.

“…Whether human cancer follows a hierarchical or stochastic model of differentiation is controversial. Furthermore, the factors that regulate cancer stem-like…”
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Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis by Fan, Huihui, Atiya, Huda I., Wang, Yeh, Pisanic, Thomas R., Wang, Tza-Huei, Shih, Ie-Ming, Foy, Kelly K., Frisbie, Leonard, Buckanovich, Ronald J., Chomiak, Alison A., Tiedemann, Rochelle L., Rothbart, Scott B., Chandler, Chelsea, Shen, Hui, Coffman, Lan G.

“…A role for cancer cell epithelial-to-mesenchymal transition (EMT) in cancer is well established. Here, we show that, in addition to cancer cell EMT, ovarian…”
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Regulatory effects of ferritin on angiogenesis by Coffman, Lan G, Parsonage, Derek, D'Agostino, Ralph Jr, Torti, Frank M, Torti, Suzy V

“…Angiogenesis, the synthesis of new blood vessels from preexisting vessels, plays a critical role in normal wound healing and tumor growth. HKa (cleaved high…”
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Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression by Javed, Zaineb, Shin, Dong Hui, Pan, Weihua, White, Sierra R, Elhaw, Amal Taher, Kim, Yeon Soo, Kamlapurkar, Shriya, Cheng, Ya-Yun, Benson, J Cory, Abdelnaby, Ahmed Emam, Phaëton, Rébécca, Wang, Hong-Gang, Yang, Shengyu, Sullivan, Mara L G, St.Croix, Claudette M, Watkins, Simon C, Mullett, Steven J, Gelhaus, Stacy L, Lee, Nam, Coffman, Lan G, Aird, Katherine M, Trebak, Mohamed, Mythreye, Karthikeyan, Walter, Vonn, Hempel, Nadine

“…Aberrant mitochondrial fission/fusion dynamics are frequently associated with pathologies, including cancer. We show that alternative splice variants of the…”
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Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition by Cascio, Sandra, Chandler, Chelsea, Zhang, Linan, Sinno, Sarah, Gao, Bingsi, Onkar, Sayali, Bruno, Tullia C, Vignali, Dario A A, Mahdi, Haider, Osmanbeyoglu, Hatice U, Vlad, Anda M, Coffman, Lan G, Buckanovich, Ronald J

“…We investigated the impact of cancer-associated mesenchymal stem cells (CA-MSCs) on ovarian tumor immunity. In patient samples, CA-MSC presence inversely…”
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Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22 by Espinal, Alexis, Epperly, Michael W, Mukherjee, Amitava, Fisher, Renee, Shields, Donna, Wang, Hong, Huq, M Saiful, Hamade, Diala Fatima, Vlad, Anda M, Coffman, Lan, Buckanovich, Ronald, Yu, Jian, Leibowitz, Brian J, van Pijkeren, Jan-Peter, Patel, Ravi B, Stolz, Donna, Watkins, Simon, Ejaz, Asim, Greenberger, Joel S

“…(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by…”
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An Orthotopic Mouse Model of Ovarian Cancer using Human Stroma to Promote Metastasis by Atiya, Huda I, Orellana, Taylor J, Wield, Alyssa, Frisbie, Leonard, Coffman, Lan G

“…Ovarian cancer is characterized by early, diffuse metastasis with 70% of women having metastatic disease at the time of diagnosis. While elegant transgenic…”
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