Search Results - "Coffino, P."

Ubiquitin-free routes into the proteasome by Hoyt, M A, Coffino, P

“…The majority of proteasome substrates identified to date are marked for degradation by polyubiquitinylation. Exceptions to this principle, however, are well…”
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Ubiquitin-proteasome system: Ubiquitin-free routes into the proteasome by Hoyt, M.A., Coffino, P.

“…The majority of proteasome substrates identified to date are marked for degradation by polyubiquitinylation. Exceptions to this principle, however, are well…”
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Antizyme, a mediator of ubiquitin-independent proteasomal degradation by Coffino, Philip

“…Ornithine decarboxylase (ODC) is among the small set of proteasome substrates that is not ubiquitinated. It is instead degraded in conjunction with the protein…”
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High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation by Li, X, Coffino, P

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Polyamines in Spermiogenesis: Not Now, Darling by Coffino, Philip

“…The pattern of AZ3, an antizyme family member, expression suggests that it acts to sharply limit polyamine accumulation in cells that have finished DNA…”
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Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein by XIANQIANG LI, COFFINO, P

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Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme by LI, X, COFFINO, P

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Sequestered end products and enzyme regulation : the case of ornithine decarboxylase by DAVIS, R. H, MORRIS, D. R, COFFINO, P

“…The polyamines (putrescine, spermidine, and spermine) are synthesized by almost all organisms and are universally required for normal growth. Ornithine…”
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Regulation of cellular polyamines by antizyme by Coffino, Philip

“…Proteins that are degraded by the proteasome are first modified by a set of enzymes that attach multiple copies of ubiquitin to substrate lysines, but a tiny…”
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Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase by XIANQIANG LI, COFFINO, P

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Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition by Phillips, M A, Coffino, P, Wang, C C

“…Ornithine decarboxylase of the African trypanosome Trypanosoma brucei brucei had an estimated native molecular weight of 100,000 by gel filtration and a…”
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Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation by GHODA, L, SIDNEY, D, MACRAE, M, COFFINO, P

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Prevention of Rapid Intracellular Degradation of ODC by a Carboxyl-Terminal Truncation by Ghoda, L., T. Van Daalen Wetters, Macrae, M., Ascherman, D., Coffino, P.

“…Ornithine decarboxylase (ODC) was converted from a protein with a short intracellular half-life in mammalian cells to a stable protein by truncating 37…”
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Mouse ornithine decarboxylase. Complete amino acid sequence deduced from cDNA by Gupta, M, Coffino, P

“…cDNA containing the full coding region of mouse ornithine decarboxylase was isolated. The complete nucleotide sequence of the cDNA was determined by the…”
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Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational by VAN DAALEN WETTERS, T, MACRAE, M, BRABANT, M, SITTLER, A, COFFINO, P

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Molecular Cloning and Expression of the Mouse Ornithine Decarboxylase Gene by McConlogue, Lisa, Gupta, Madhu, Wu, Lily, Coffino, Philip

“…We used mRNA from a mutant S49 mouse lymphoma cell line that produces ornithine decarboxylase (OrnDCase) as its major protein product to synthesize and clone…”
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Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation by GHODA, L, PHILLIPS, M. A, BASS, K. E, WANG, C. C, COFFINO, P

“…Ornithine decarboxylase (ODC) is a key enzyme in polyamine biosynthesis. Mouse ODC is rapidly degraded in mouse cells, whereas ODC within Trypanosoma brucei, a…”
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Dominant negative mutants of ornithine decarboxylase by TSIRKA, S, COFFINO, P

“…Conserved lysines of mouse ornithine decarboxylase were individually mutated to arginines. The mutations at amino acid residues 69, 115, and 169 greatly…”
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Multiple mechanisms are responsible for altered expression of ornithine decarboxylase in overproducing variant cells by MCCONLOGUE, L, DANA, S. L, COFFINO, P

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The Ornithine Decarboxylase Gene of Caenorhabditis elegans: Cloning, Mapping and Mutagenesis by Macrae, M, Plasterk, RHA, Coffino, P

“…The gene (odc-1) encoding ornithine decarboxylase, a key enzyme in polyamine biosynthesis, was cloned and characterized. Two introns interrupt the coding…”
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