Search Results - "Coffin, J. M"

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells by Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., Coffin, J. M., Hughes, S. H.

“…The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV…”
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HIV reservoirs and the possibility of a cure for HIV infection by Palmer, S., Josefsson, L., Coffin, J. M.

“…  Palmer S, Josefsson L, Coffin JM (Karolinska Institutet, Solna; Swedish Institute for Infectious Disease Control, Solna, Sweden; and Tufts University,…”
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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy by Archin, N. M., Liberty, A. L., Kashuba, A. D., Choudhary, S. K., Kuruc, J. D., Crooks, A. M., Parker, D. C., Anderson, E. M., Kearney, M. F., Strain, M. C., Richman, D. D., Hudgens, M. G., Bosch, R. J., Coffin, J. M., Eron, J. J., Hazuda, D. J., Margolis, D. M.

“…The latent HIV-1 reservoir represents a major barrier to curing patients with HIV-1 infection, and now in vivo evidence is presented that vorinostat can…”
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Short-Course Raltegravir Intensification Does Not Reduce Persistent Low-Level Viremia in Patients with HIV-1 Suppression during Receipt of Combination Antiretroviral Therapy by McMahon, D., Jones, J., Wiegand, A., Gange, S. J., Kearney, M., Palmer, S., McNulty, S., Metcalf, J. A., Acosta, E., Rehm, C., Coffin, J. M., Mellors, J. W., Maldarelli, F.

“…Background. Combination antiretroviral therapy suppresses but does not eradicate human immunodeficiency virus type 1 (HIV-1) in infected persons, and low-level…”
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Human Immunodeficiency Virus Type 1 Population Genetics and Adaptation in Newly Infected Individuals by KEARNEY, M, MALDARELLI, F, SHAO, W, MARGOLICK, J. B, DAAR, E. S, MELLORS, J. W, RAO, V, COFFIN, J. M, PALMER, S

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Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy by Dinoso, J.B, Kim, S.Y, Wiegand, A.M, Palmer, S.E, Gange, S.J, Cranmer, L, O'Shea, A, Callender, M, Spivak, A, Brennan, T, Kearney, M.F, Proschan, M.A, Mican, J.M, Rehm, C.A, Coffin, J.M, Mellors, J.W, Siliciano, R.F, Maldarelli, F

“…In HIV-1-infected individuals on currently recommended antiretroviral therapy (ART), viremia is reduced to <50 copies of HIV-1 RNA per milliliter, but…”
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Evolution of Human Immunodeficiency Virus Under Selection and Weak Recombination by Rouzine, I. M, Coffin, J. M

“…To predict emergence of drug resistance in patients undergoing antiretroviral therapy, we study accumulation of preexisting beneficial alleles in a haploid…”
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Transition between Stochastic Evolution and Deterministic Evolution in the Presence of Selection: General Theory and Application to Virology by ROUZINE, I. M, RODRIGO, A, COFFIN, J. M

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HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy by Coffin, John M.

“…Several recent reports indicate that the long, clinically latent phase that characterizes human immunodeficiency virus (HIV) infection of humans is not a…”
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A robust measure of HIV-1 population turnover within chronically infected individuals by Achaz, G, Palmer, S, Kearney, M, Maldarelli, F, Mellors, J W, Coffin, J M, Wakeley, J

“…A simple nonparameteric test for population structure was applied to temporally spaced samples of HIV-1 sequences from the gag-pol region within two…”
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Linkage Disequilibrium Test Implies a Large Effective Population Number for HIV in vivo by Rouzine, I. M., Coffin, J. M.

“…The effective size of the HIV population in vivo, although critically important for the prediction of appearance of drug-resistant variants, is currently…”
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Human immunodeficiency virus drug therapy and virus load by Bonhoeffer, S, Coffin, J M, Nowak, M A

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Increasing Sequence Correlation Limits the Efficiency of Recombination in a Multisite Evolution Model by Gheorghiu-Svirschevski, S., Rouzine, IM, Coffin, JM

“…The accumulation of preexisting beneficial alleles in a haploid population, under selection and infrequent recombination, and in the absence of new mutation…”
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Search for the Mechanism of Genetic Variation in the pro Gene of Human Immunodeficiency Virus by Rouzine, I M, Coffin, J M

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HIV viral dynamics by Coffin, J M

“…Elucidation of the underlying rapid turnover of virus and HIV infected cells in vivo was perhaps the most informative and exciting discovery in HIV and AIDS…”
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Genetic diversity and evolution of retroviruses by Coffin, J M

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A Linkage Map of Endogenous Murine Leukemia Proviruses by Frankel, W. N, Stoye, J. P, Taylor, B. A, Coffin, J. M

“…Thirty endogenous proviruses belonging to the modified polytropic (Mpmv) class of murine leukemia virus (MLV) were identified by proviral-cellular DNA junction…”
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Localization of a Retroviral Element within the rd Gene Coding for the β Subunit of cGMP Phosphodiesterase by Bowes, Cathy, Li, Tiansen, Frankel, Wayne N., Danciger, Michael, Coffin, John M., Applebury, Meredithe L., Farber, Debora B.

“…Retinal degeneration in the rd mouse is inherited as an autosomal recessive trait and is caused by a defect in the gene encoding the β subunit of cGMP…”
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Virological events leading to spontaneous AKR thymomas by STOYE, J. P, MORONI, C, COFFIN, J. M

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Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples by Spindler, J., Wiegand, A., Bagni, R. K., Lee, K., Kearney, M. F., Maldarelli, F., Pinto, Peter A., Linehan, W. Marston, Vocke, C. D., Delviks-Frankenberry, K. A., deVere White, R. W., Del Prete, G. Q., Mellors, John W., Lifson, J. D., KewalRamani, V. N., Pathak, V. K., Coffin, J. M., Le Grice, Stuart F. J.

“…The MLV-related retrovirus, XMRV, was recently identified and reported to be associated with both prostate cancer and chronic fatigue syndrome. At the National…”
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