Search Results - "Coffin, Christopher C."

Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo by Mullen, Patricia M, Lollo, Charles P, Phan, Quynh-Chi, Amini, Arjang, Banaszczyk, Mariusz G, Fabrycki, Joanne M, Wu, Dongpei, Carlo, Alison T, Pezzoli, Patrick, Coffin, Christopher C, Carlo, Dennis J

“…In vitro assays have demonstrated the capability of poly- L-lysine to protect plasmid DNA from serum nucleases and cellular lysates. Our purpose was to…”
Get full text

Phosphorothioate Oligonucleotides with Low Phosphate Diester Content:  Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS) by Krotz, Achim H, Gorman, Dennis, Mataruse, Paul, Foster, Craig, Godbout, James D, Coffin, Christopher C, Scozzari, Anthony N

“…In this report, we describe the design of an efficient and robust sulfurization step in the production process of phosphorothioate (PS) oligonucleotides by…”
Get full text

Stabilization of poly- l-lysine/DNA polyplexes for in vivo gene delivery to the liver by Kwoh, Deborah Y., Coffin, Christopher C., Lollo, Charles P., Jovenal, Jocelyn, Banaszczyk, Mariusz G., Mullen, Patricia, Phillips, Alison, Amini, Arjang, Fabrycki, Joanne, Bartholomew, Richard M., Brostoff, Steven W., Carlo, Dennis J.

“…We are developing a self-assembling non-viral in vivo gene delivery vehicle based on poly- l-lysine and plasmid DNA. We have characterized poly- l-lysines of…”
Get full text

Poly-L-lysine-based gene delivery systems. Synthesis, purification, and application by Lollo, Charles P, Banaszczyk, Mariusz G, Mullen, Patricia M, Coffin, Christopher C, Wu, Dongpei, Carlo, Alison T, Bassett, Donna L, Gouveia, Erin K, Carlo, Dennis J

Get more information

Gene therapy strategies for the treatment of chronic viral hepatitis by Chiou, H C, Lucas, M A, Coffin, C C, Banaszczyk, M G, Ill, C R, Lollo, C P

“…Chronic viral hepatitis is a major clinical problem, with over half a billion persons infected worldwide. Current therapies, principally treatment with…”
Get more information

POLY-L-LYSINE-GRAFT-PEG COMB-TYPE POLYCATION COPOLYMERS FOR GENE DELIVERY by BANASZCZYK, MARIUSZ G., LOLLO, CHARLES P., KWOH, DEBORAH Y., PHILLIPS, ALISON T., AMINI, ARJANG, WU, DUNCAN P., MULLEN, PATRICIA M., COFFIN, CHRISTOPHER C., BROSTOFF, STEVEN W., CARLO, DENNIS J.

“…Polycations have been used for gene delivery in vitro quite successfully, however, in vivo applications suffered from serum effects that lower the overall gene…”
Get full text

Non-viral gene delivery: vehicle and delivery characterization by Lollo, C P, Kwoh, D Y, Mockler, T C, Ley, P M, Guido, M S, Coffin, C C, Aleman, R, Bartholomew, R M, Carlo, D J

“…The development of non-viral gene therapy has been hampered by an inability to reproducibly manufacture and characterize delivery system components and final…”
Get more information