Search Results - "Coffey, Robert J."

EGF receptor ligands: recent advances [version 1; peer review: 3 approved] by Singh, Bhuminder, Carpenter, Graham, Coffey, Robert J

“…Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor (EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA),…”
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Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells by Singh, Bhuminder, Coffey, Robert J

“…A largely unilamellar epithelial layer lines body cavities and organ ducts such as the digestive tract and kidney tubules. This polarized epithelium is…”
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KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes by McKenzie, Andrew J., Hoshino, Daisuke, Hong, Nan Hyung, Cha, Diana J., Franklin, Jeffrey L., Coffey, Robert J., Patton, James G., Weaver, Alissa M.

“…Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA)…”
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The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor by Powell, Anne E., Wang, Yang, Li, Yina, Poulin, Emily J., Means, Anna L., Washington, Mary K., Higginbotham, James N., Juchheim, Alwin, Prasad, Nripesh, Levy, Shawn E., Guo, Yan, Shyr, Yu, Aronow, Bruce J., Haigis, Kevin M., Franklin, Jeffrey L., Coffey, Robert J.

“…Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the molecular circuitry controlling stem cell quiescence is…”
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Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation by Banerjee, Amrita, Herring, Charles A., Chen, Bob, Kim, Hyeyon, Simmons, Alan J., Southard-Smith, Austin N., Allaman, Margaret M., White, James R., Macedonia, Mary C., Mckinley, Eliot T., Ramirez-Solano, Marisol A., Scoville, Elizabeth A., Liu, Qi, Wilson, Keith T., Coffey, Robert J., Washington, M. Kay, Goettel, Jeremy A., Lau, Ken S.

“…Countries endemic for parasitic infestations have a lower incidence of Crohn’s disease (CD) than nonendemic countries, and there have been anecdotal reports of…”
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Transfer of Functional Cargo in Exomeres by Zhang, Qin, Higginbotham, James N., Jeppesen, Dennis K., Yang, Yu-Ping, Li, Wei, McKinley, Eliot T., Graves-Deal, Ramona, Ping, Jie, Britain, Colleen M., Dorsett, Kaitlyn A., Hartman, Celine L., Ford, David A., Allen, Ryan M., Vickers, Kasey C., Liu, Qi, Franklin, Jeffrey L., Bellis, Susan L., Coffey, Robert J.

“…Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Herein, we describe a simple ultracentrifugation-based…”
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Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS by Demory Beckler, Michelle, Higginbotham, James N., Franklin, Jeffrey L., Ham, Amy-Joan, Halvey, Patrick J., Imasuen, Imade E., Whitwell, Corbin, Li, Ming, Liebler, Daniel C., Coffey, Robert J.

“…Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell…”
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Amphiregulin Exosomes Increase Cancer Cell Invasion by Higginbotham, James N., Demory Beckler, Michelle, Gephart, Jonathan D., Franklin, Jeffrey L., Bogatcheva, Galina, Kremers, Gert-Jan, Piston, David W., Ayers, Gregory D., McConnell, Russell E., Tyska, Matthew J., Coffey, Robert J.

“…Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG),…”
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Resistance to EGFR-Targeted Therapy: A Family Affair by Vlacich, Gregory, Coffey, Robert J.

“…The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study,…”
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Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression by Liu, Hao, Li, Danxiu, Sun, Lina, Qin, Hongqiang, Fan, Ahui, Meng, Lingnan, Graves-Deal, Ramona, Glass, Sarah E, Franklin, Jeffrey L, Liu, Qi, Wang, Jing, Yeatman, Timothy J, Guo, Hao, Zong, Hong, Jin, Shuilin, Chen, Zhiyu, Deng, Ting, Fang, Ying, Li, Cunxi, Karijolich, John, Patton, James G, Wang, Xin, Nie, Yongzhan, Fan, Daiming, Coffey, Robert J, Zhao, Xiaodi, Lu, Yuanyuan

“…Abstract Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing…”
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From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease by Singh, Bhuminder, Coffey, Robert J.

“…•TGFA is an EGFR ligand.•TGFA surface delivery and cleavage are two important regulatory steps.•Forced expression of TGFA acts as epithelial mitogen and…”
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KRAS-dependent sorting of miRNA to exosomes by Cha, Diana J, Franklin, Jeffrey L, Dou, Yongchao, Liu, Qi, Higginbotham, James N, Demory Beckler, Michelle, Weaver, Alissa M, Vickers, Kasey, Prasad, Nirpesh, Levy, Shawn, Zhang, Bing, Coffey, Robert J, Patton, James G

“…Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also…”
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Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach by Choi, Eunyoung, Lantz, Tyler L, Vlacich, Gregory, Keeley, Theresa M, Samuelson, Linda C, Coffey, Robert J, Goldenring, James R, Powell, Anne E

“…Lrig1 is a marker of proliferative and quiescent stem cells in the skin and intestine. We examined whether Lrig1-expressing cells are long-lived gastric…”
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Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells by Hinger, Scott A., Cha, Diana J., Franklin, Jeffrey L., Higginbotham, James N., Dou, Yongchao, Ping, Jie, Shu, Lihua, Prasad, Nripesh, Levy, Shawn, Zhang, Bing, Liu, Qi, Weaver, Alissa M., Coffey, Robert J., Patton, James G.

“…The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS…”
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NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling by Tanksley, Jarred P, Chen, Xi, Coffey, Robert J

“…The NEDD4 family of E3 ubiquitin ligases includes nine members. Each is a modular protein, containing an N-terminal C2 domain for cell localization,…”
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Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions by Shifrin, David A., McConnell, Russell E., Nambiar, Rajalakshmi, Higginbotham, James N., Coffey, Robert J., Tyska, Matthew J.

“…The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption and as a physical barrier to…”
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Extracellular vesicles: communication, coercion, and conditioning by Shifrin, Jr, David A, Demory Beckler, Michelle, Coffey, Robert J, Tyska, Matthew J

“…Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied…”
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A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer by Cao, Tianyu, Lu, Yuanyuan, Wang, Qi, Qin, Hongqiang, Li, Hongwei, Guo, Hao, Ge, Minghui, Glass, Sarah E, Singh, Bhuminder, Zhang, Wenyao, Dong, Jiaqiang, Du, Feng, Qian, Airong, Tian, Ye, Wang, Xin, Li, Cunxi, Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Coffey, Robert J, Zhao, Xiaodi

“…De novo and acquired resistance are major impediments to the efficacy of conventional and targeted cancer therapy. In unselected gastric cancer (GC) patients…”
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A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin by Kondo, Jumpei, Huh, Won Jae, Franklin, Jeffrey L, Heinrich, Michael C, Rubin, Brian P, Coffey, Robert J

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gut. GISTs are thought to arise solely from interstitial cells of Cajal…”
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Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress by Byrd, Kevin M., Piehl, Natalie C., Patel, Jeet H., Huh, Won Jae, Sequeira, Inês, Lough, Kendall J., Wagner, Bethany L., Marangoni, Pauline, Watt, Fiona M., Klein, Ophir D., Coffey, Robert J., Williams, Scott E.

“…Stem cells in stratified epithelia are generally believed to adhere to a non-hierarchical single-progenitor model. Using lineage tracing and genetic…”
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