Search Results - "Coffey, Marcus J"

Activated Platelets and Monocytes Generate Four Hydroxyphosphatidylethanolamines via Lipoxygenase by Maskrey, Benjamin H., Bermúdez-Fajardo, Alexandra, Morgan, Alwena H., Stewart-Jones, Esther, Dioszeghy, Vincent, Taylor, Graham W., Baker, Paul R.S., Coles, Barbara, Coffey, Marcus J., Kühn, Hartmut, O'Donnell, Valerie B.

“…12/15-Lipoxygenase (LOX) mediates immune-regulatory activities not accounted for by its known free acid eicosanoids, suggesting that additional lipids may be…”
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Developing a personalised, evidence-based and inclusive learning (PEBIL) model of blended learning: A cross-sectional survey by Hassoulas, Athanasios, de Almeida, Andreia, West, Hannah, Abdelrazek, Mohamed, Coffey, Marcus J.

“…Whilst the use of various blended learning models preceded the COVID-19 pandemic, the abrupt shift to remote delivery served as catalyst within the sector in…”
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Nitrolinoleate Inhibits Platelet Activation by Attenuating Calcium Mobilization and Inducing Phosphorylation of Vasodilator-stimulated Phosphoprotein through Elevation of cAMP by Coles, Barbara, Bloodsworth, Allison, Eiserich, Jason P., Coffey, Marcus J., McLoughlin, Rachel M., Giddings, John C., Lewis, Malcolm J., Haslam, Richard J., Freeman, Bruce A., O'Donnell, Valerie B.

“…Reactive species formed from nitric oxide (NO) nitrate unsaturated fatty acids such as linoleate (LA) to nitrated derivatives including nitrolinoleate (LNO2)…”
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Evidence for Significant Differences in Microsomal Drug Glucuronidation by Canine and Human Liver and Kidney by SOARS, Matthew G, RILEY, Robert J, FINDLAY, Karen A. B, COFFEY, Marcus J, BURCHELL, Brian

“…The in vitro glucuronidation of a range of structurally diverse chemicals has been studied in hepatic and renal microsomes from human donors and the beagle…”
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Catalytic Consumption of Nitric Oxide by 12/15-Lipoxygenase: Inhibition of Monocyte Soluble Guanylate Cyclase Activation by Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, Kühn, Hartmut, Lewis, Malcolm J., Freeman, Bruce A., O'Donnell, Valerie B.

“…12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide (·NO) bioactivity, such as hypertension and…”
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Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover by Clark, Stephen R, Anning, Peter B, Coffey, Marcus J, Roberts, Andrew G, Marnett, Lawrence J, O'Donnell, Valerie B

“…PGHS-2 (prostaglandin H synthase-2) is induced in mammalian cells by pro-inflammatory cytokines in tandem with iNOS [high-output ('inducible') nitric oxide…”
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Platelet 12-Lipoxygenase Activation via Glycoprotein VI: Involvement of Multiple Signaling Pathways in Agonist Control of H(P)ETE Synthesis by Coffey, Marcus J, Jarvis, Gavin E, Gibbins, Jonathan M, Coles, Barbara, Barrett, Natasha E, Wylie, Oliver R.E, O’Donnell, Valerie B

“…Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid…”
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Generation of active oxygen in elicited cells of Arabidopsis thaliana is mediated by a NADPH oxidase-like enzyme by Desikan, Radhika, Hancock, John T., Coffey, Marcus J., Neill, Steven J.

“…Suspension-cultured cells of Arabidopsis thaliana generated active oxygen species (AOS) (measured by luminol-dependent chemiluminescence) following challenge…”
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In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets by Williams, P. Claire, Coffey, Marcus J., Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John R., Lewis, Malcolm J., O'Donnell, Valerie B.

“…Antiplatelet therapies improve endothelial function in atherosclerosis, suggesting that platelets regulate vascular nitric oxide (NO) bioactivity in vivo…”
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Interactions of 12‐lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor by Coffey, Marcus J., Coles, Barbara, Locke, Matthew, Bermudez-Fajardo, Alexandra, Williams, P.Claire, Jarvis, Gavin E., O'Donnell, Valerie B.

“…Recent studies implicate the collagen receptor, glycoprotein VI (GPVI) in activation of platelet 12‐lipoxygenase (p12‐LOX). Herein, we show that…”
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Characterization of Nitric Oxide Consumption Pathways by Normal, Chronic Granulomatous Disease and Myeloperoxidase-Deficient Human Neutrophils by Clark, Stephen R, Coffey, Marcus J, Maclean, Rhona M, Collins, Peter W, Lewis, Malcolm J, Cross, Andrew R, O'Donnell, Valerie B

“…The detailed mechanisms by which acutely activated leukocytes metabolize NO and regulate its bioactivity are unknown. Therefore, healthy, chronic granulomatous…”
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Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats by Braun, L, Coffey, M J, Puskás, F, Kardon, T, Nagy, G, Conley, A A, Burchell, B, Mandl, J

“…The co-ordinated induction of several hepatic drug-metabolizing enzymes is a common feature in the regulation of drug biotransformation under normal and…”
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Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase by Maskrey, Benjamin H., Bermúdez-Fajardo, Alexandra, Morgan, Alwena H., Stewart-Jones, Esther, Dioszeghy, Vincent, Taylor, Graham W., Baker, Paul R.S., Coles, Barbara, Coffey, Marcus J., Kühn, Hartmut, O'Donnell, Valerie B.

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Interactions of 12-lipoxygenase with phospholipase A 2 isoforms following platelet activation through the glycoprotein VI collagen receptor by Coffey, Marcus J., Coles, Barbara, Locke, Matthew, Bermudez-Fajardo, Alexandra, Williams, P.Claire, Jarvis, Gavin E., O'Donnell, Valerie B.

“…Recent studies implicate the collagen receptor, glycoprotein VI (GPVI) in activation of platelet 12-lipoxygenase (p12-LOX). Herein, we show that…”
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Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases by Coffey, M J, Coles, B, O'Donnell, V B

“…Nitric oxide (NO) is a major free radical modulator of smooth muscle tone, which under basal conditions acts to preserve vascular homeostasis through its…”
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Elicitor-induced generation of active oxygen in suspension cultures of Arabidopsis thaliana by Desikan, R, Hancock, J T, Neill, S J, Coffey, M J, Jones, O T

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