Search Results - "Coffey, Eleanor T"

Microtubule and microtubule associated protein anomalies in psychiatric disease by Marchisella, Francesca, Coffey, Eleanor T., Hollos, Patrik

“…Anomalies in neuronal cell architecture, in particular dendritic complexity and synaptic density changes, are widely observed in the brains of subjects with…”
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Repositioning Microtubule Stabilizing Drugs for Brain Disorders by Varidaki, Artemis, Hong, Ye, Coffey, Eleanor T

“…Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell…”
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Nuclear and cytosolic JNK signalling in neurons by Coffey, Eleanor T.

“…Key Points JUN amino-terminal kinases (JNKs) are dominant regulators of protein phosphorylation in the nervous system. JNKs serve critical functions in…”
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Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin by Brady, Scott T, Coffey, Eleanor T, You, Yi-Mei, Pollema, Sarah L, Kaminska, Agnieszka, Pigino, Gustavo, Han, David, Björkblom, Benny, Liu, Katherine, Bagnato, Carolina, Morfini, Gerardo A, Banker, Gary, Huang, Chun-Fang, Yoshioka, Katsuji

“…PolyQ-Htt inhibits fast axonal transport in cellular and animal Huntington's disease models. Here, the authors show that this effect is a result of the…”
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Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate by Coffey, Eleanor T, Westerlund, Nina, Zdrojewska, Justyna, Padzik, Artur, Komulainen, Emilia, Björkblom, Benny, Rannikko, Emmy, Tararuk, Tanya, Garcia-Frigola, Cristina, Sandholm, Jouko, Nguyen, Laurent, Kallunki, Tuula, Courtney, Michael J

“…Westerlund and colleagues show that c-Jun N-terminal protein kinase 1 (JNK1), via phosphorylation of SCG10/Stathmin-2, acts as a negative regulator of the rate…”
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c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells by Björkblom, Benny, Padzik, Artur, Mohammad, Hasan, Westerlund, Nina, Komulainen, Emilia, Hollos, Patrik, Parviainen, Lotta, Papageorgiou, Anastassios C., Iljin, Kristiina, Kallioniemi, Olli, Kallajoki, Markku, Courtney, Michael J., Mågård, Mats, James, Peter, Coffey, Eleanor T.

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Microtubule Stabilization by Bone Morphogenetic Protein Receptor-Mediated Scaffolding of c-Jun N-Terminal Kinase Promotes Dendrite Formation by Podkowa, Monika, Zhao, Xin, Chow, Chi-Wing, Coffey, Eleanor T., Davis, Roger J., Attisano, Liliana

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PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins by Santio, Niina M, Vainio, Veera, Hoikkala, Tuuli, Mung, Kwan Long, Lång, Mirka, Vahakoski, Riitta, Zdrojewska, Justyna, Coffey, Eleanor T, Kremneva, Elena, Rainio, Eeva-Marja, Koskinen, Päivi J

“…The PIM family kinases promote cancer cell survival and motility as well as metastatic growth in various types of cancer. We have previously identified several…”
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Impact of JNK and Its Substrates on Dendritic Spine Morphology by Komulainen, Emilia, Varidaki, Artemis, Kulesskaya, Natalia, Mohammad, Hasan, Sourander, Christel, Rauvala, Heikki, Coffey, Eleanor T

“…The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal…”
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Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression by Hollos, Patrik, John, Jismi M, Lehtonen, Jukka V, Coffey, Eleanor T

“…In this study, we use an optogenetic inhibitor of c-Jun NH -terminal kinase (JNK) in dendritic spine sub-compartments of rat hippocampal neurons. We show that…”
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JNK1 Phosphorylation of SCG10 Determines Microtubule Dynamics and Axodendritic Length by Tatsiana Tararuk, Nina Östman, Wenrui Li, Benny Björkblom, Artur Padzik, Justyna Zdrojewska, Vesa Hongisto, Thomas Herdegen, Witold Konopka, Courtney, Michael J., Eleanor T. Coffey

“…C-Jun NH2-terminal kinases (JNKs) are essential during brain development, when they regulate morphogenic changes involving cell movement and migration. In the…”
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All JNKs Can Kill, but Nuclear Localization Is Critical for Neuronal Death by Björkblom, Benny, Vainio, Jenni C., Hongisto, Vesa, Herdegen, Thomas, Courtney, Michael J., Coffey, Eleanor T.

“…JNKs are implicated in a range of brain pathologies and receive considerable attention as potential therapeutic targets. However, JNKs also regulate…”
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JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination by Komulainen, Emilia, Zdrojewska, Justyna, Freemantle, Erika, Mohammad, Hasan, Kulesskaya, Natalia, Deshpande, Prasannakumar, Marchisella, Francesca, Mysore, Raghavendra, Hollos, Patrik, Michelsen, Kimmo A, Mågard, Mats, Rauvala, Heikki, James, Peter, Coffey, Eleanor T

“…Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a…”
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Constitutively Active Cytoplasmic c-Jun N-Terminal Kinase 1 Is a Dominant Regulator of Dendritic Architecture: Role of Microtubule-Associated Protein 2 as an Effector by Bjorkblom, Benny, Ostman, Nina, Hongisto, Vesa, Komarovski, Vladislav, Filen, Jan-Jonas, Nyman, Tuula A, Kallunki, Tuula, Courtney, Michael J, Coffey, Eleanor T

“…Normal functioning of the nervous system requires precise regulation of dendritic shape and synaptic connectivity. Here, we report a severe impairment of…”
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The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis by Matlawska-Wasowska, Ksenia, Finn, Rebecca, Mustel, Ana, O'Byrne, Conor P, Baird, Alan W, Coffey, Eleanor T, Boyd, Aoife

“…Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type…”
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KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons by Padzik, Artur, Deshpande, Prasannakumar, Hollos, Patrik, Franker, Mariella, Rannikko, Emmy H, Cai, Dawen, Prus, Piotr, Mågård, Mats, Westerlund, Nina, Verhey, Kristen J, James, Peter, Hoogenraad, Casper C, Coffey, Eleanor T

“…Increased phosphorylation of the KIF5 anterograde motor is associated with impaired axonal transport and neurodegeneration, but paradoxically also with normal…”
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c-Jun N-Terminal Protein Kinase (JNK) 2/3 Is Specifically Activated by Stress, Mediating c-Jun Activation, in the Presence of Constitutive JNK1 Activity in Cerebellar Neurons by Coffey, Eleanor T, Smiciene, Giedre, Hongisto, Vesa, Cao, Jiong, Brecht, Stephan, Herdegen, Thomas, Courtney, Michael J

“…c-Jun is considered a major regulator of both neuronal death and regeneration. Stress in primary cultured CNS neurons induces phosphorylation of c-Jun serines…”
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Lithium Blocks the c-Jun Stress Response and Protects Neurons via Its Action on Glycogen Synthase Kinase 3 by Hongisto, Vesa, Smeds, Nina, Brecht, Stephan, Herdegen, Thomas, Courtney, Michael J., Coffey, Eleanor T.

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Chondroitin Sulfate‐Coated Heteroduplex‐Molecular Spherical Nucleic Acids by Virta, Pasi, Laine, Toni, Deshpande, Prasannakumar, Tähtinen, Ville, Coffey, Eleanor T.

“…Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial…”
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The Wnt Pool of Glycogen Synthase Kinase 3β Is Critical for Trophic-Deprivation-Induced Neuronal Death by Hongisto, Vesa, Vainio, Jenni C., Thompson, Róisín, Courtney, Michael J., Coffey, Eleanor T.

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