Search Results - "Coffey, E."

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP by Coffey, E.E, Beckel, J.M, Laties, A.M, Mitchell, C.H

“…Graphical abstract The elevation of lysosomal pH associated with mutations in PS1-fAD prevents degradative enzymes from properly processing cellular waste…”
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Milk production and fertility performance of Holstein, Friesian, and Jersey purebred cows and their respective crosses in seasonal-calving commercial farms by Coffey, E L, Horan, B, Evans, R D, Berry, D P

“…There is renewed interest in dairy cow crossbreeding in Ireland as a means to further augment productivity and profitability. The objective of the present…”
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Memory impairment in transgenic Alzheimer mice requires cellular prion protein by Gimbel, David A, Nygaard, Haakon B, Coffey, Erin E, Gunther, Erik C, Laurén, Juha, Gimbel, Zachary A, Strittmatter, Stephen M

“…Soluble oligomers of the amyloid-beta (Abeta) peptide are thought to play a key role in the pathophysiology of Alzheimer's disease (AD). Recently, we reported…”
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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification by Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P.Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr, Nixon, Ralph A.

“…Presenilin 1 (PS1) deletion or Alzheimer’s disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we…”
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Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain by Beckel, Jonathan M., Argall, Arthur J., Lim, Jason C., Xia, Jingsheng, Lu, Wennan, Coffey, Erin E., Macarak, Edward J., Shahidullah, Mohammed, Delamere, Nicholas A., Zode, Gulab S., Sheffield, Val C., Shestopalov, Valery I., Laties, Alan M., Mitchell, Claire H.

“…As adenosine 5′‐triphosphate (ATP) released from astrocytes can modulate many neural signaling systems, the triggers and pathways for this ATP release are…”
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The Greenwich Photo-heliographic Results (1874 – 1976): Summary of the Observations, Applications, Datasets, Definitions and Errors by Willis, D. M., Coffey, H. E., Henwood, R., Erwin, E. H., Hoyt, D. V., Wild, M. N., Denig, W. F.

“…The measurements of sunspot positions and areas that were published initially by the Royal Observatory, Greenwich, and subsequently by the Royal Greenwich…”
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A modified Valsalva maneuver was more effective than standard Valsalva for treating supraventricular tachycardia by Coffey, E C Drake, Adams, Bruce D

“…Appelboam et al determine whether a modified Valsalva maneuver is more effective than the standard Valsalva maneuver for restoring sinus rhythm in patients…”
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JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche by Mohammad, H, Marchisella, F, Ortega-Martinez, S, Hollos, P, Eerola, K, Komulainen, E, Kulesskaya, N, Freemantle, E, Fagerholm, V, Savontous, E, Rauvala, H, Peterson, B D, van Praag, H, Coffey, E T

“…Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that improve mood and alleviate anxiety. However, the underlying mechanisms…”
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L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents by David, J., Gormley, S., McIntosh, A.L., Kebede, V., Thuery, G., Varidaki, A., Coffey, E.T., Harkin, A.

“…•Delivery of L-AAA to the PLC of Wistar rats produced an increase in immobility in the FST.•Intra hippocampal CA3 L-AAA delivery produced a deficit in the…”
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An evaluation of detailed animal characteristics influencing the lactation production efficiency of spring-calving, pasture-based dairy cattle by Evers, S.H., Delaby, L., Pierce, K.M., McCarthy, B., Coffey, E.L., Horan, B.

“…Selection for feed efficiency, the ratio of output (e.g., milk yield) to feed intake, has traditionally been limited on commercial dairy farms by the necessity…”
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Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations by Guha, Sonia, Coffey, Erin E., Lu, Wennan, Lim, Jason C., Beckel, Jonathan M., Laties, Alan M., Boesze-Battaglia, Kathleen, Mitchell, Claire H.

“…Lysosomes contribute to a multitude of cellular processes, and the pH of the lysosomal lumen plays a central mechanistic role in many of these functions. In…”
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COVID-19 outbreaks in care homes during the first wave: are Care Quality Commission ratings a good predictor of at-risk homes? by Tulloch, J.S.P., Green, R., Tunnah, C., Coffey, E., Ashton, M., Ghebrehewet, S.

“…COVID-19 placed a significant burden on the care home population during the first wave. Care Quality Commission’s care quality ratings are given to all English…”
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Effect of stocking rate and animal genotype on dry matter intake, milk production, body weight, and body condition score in spring-calving, grass-fed dairy cows by Coffey, E L, Delaby, L, Fitzgerald, S, Galvin, N, Pierce, K M, Horan, B

“…The objective of the experiment was to quantify the effect of stocking rate (SR) and animal genotype on milk production, dry matter intake (DMI), energy…”
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COVID-19 testing in outbreak-free care homes: what are the public health benefits? by Green, R., Tulloch, J.S.P., Tunnah, C., Coffey, E., Lawrenson, K., Fox, A., Mason, J., Barnett, R., Constantine, A., Shepherd, W., Ashton, M., Beadsworth, M.B.J., Vivancos, R., Hall, I., Walker, N., Ghebrehewet, S.

“…COVID-19 care home outbreaks represent a significant proportion of COVID-19 morbidity and mortality in the UK. National testing initially focused on…”
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A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest by Tolles, Juliana, Waterman, Gabriel, Coffey, Jr, Charles E, Sandoval, Rebecca, Fleischman, Ross J, Hess, Mailee, Sarff, Laura, Lewis, Roger J, Spellberg, Brad

“…Approximately half of hospitalized patients suffer functional decline due to spending the vast majority of their time in bed. Previous studies of early…”
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Integrated plant conservation through the Global Conservation Consortia by Linsky, Jean, Byrne, Amy, Handley, Vanessa, Coffey, Emily E. D., Alvarez‐Clare, Silvia, Crowley, Dan, Meyer, Abby

“…The 2020 State of the World's Plants and Fungi report revealed that two in five plant species are threatened with extinction. Despite their diverse ecosystem…”
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The Greenwich Photo-heliographic Results (1874 – 1976): Procedures for Checking and Correcting the Sunspot Digital Datasets by Willis, D. M., Henwood, R., Wild, M. N., Coffey, H. E., Denig, W. F., Erwin, E. H., Hoyt, D. V.

“…Attention is drawn to the existence of errors in the original digital dataset containing sunspot data extracted from certain sections of the printed Greenwich…”
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The “5Es” of Emergency Physician–performed Focused Cardiac Ultrasound: A Protocol for Rapid Identification of Effusion, Ejection, Equality, Exit, and Entrance by Kennedy Hall, M., Coffey, E. C., Herbst, Meghan, Liu, Rachel, Pare, Joseph R., Andrew Taylor, R., Thomas, Sheeja, Moore, Chris L., Costantino, Thomas

“…Emergency physician (EP)‐performed focused cardiac ultrasound (EP FOCUS) has been increasingly recognized as a crucial tool to help clinicians diagnose and…”
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Impact of a Father–Daughter Physical Activity Intervention: An Exploration of Fathers’ Experiences by Pollock, Emma R., Young, Myles D., Lubans, David R., Barnes, Alyce T., Eather, Narelle, Coffey, Julia E., Hansen, Vibeke, Morgan, Philip J.

“…Most family-based physical activity interventions have been modestly successful and failed to engage fathers. Also, program impact on family functioning and…”
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ecological consequences of megafaunal loss: giant tortoises and wetland biodiversity by Froyd, Cynthia A, Coffey, Emily E. D, Knaap, Willem O, Leeuwen, Jacqueline F. N, Tye, Alan, Willis, Katherine J, Sax, Dov

“…The giant tortoises of the Galápagos have become greatly depleted since European discovery of the islands in the 16th Century, with populations declining from…”
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