Search Results - "Coffee, Richard"

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  1. 1

    Non-invasive detection of a small number of bioluminescent cancer cells in vivo by Kim, Jae-Beom, Urban, Konnie, Cochran, Edward, Lee, Steve, Ang, Angel, Rice, Bradley, Bata, Adam, Campbell, Kenneth, Coffee, Richard, Gorodinsky, Alex, Lu, Zhan, Zhou, He, Kishimoto, Takashi Kei, Lassota, Peter

    Published in PloS one (23-02-2010)
    “…Early detection of tumors can significantly improve the outcome of tumor treatment. One of the most frequently asked questions in cancer imaging is how many…”
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    Journal Article
  2. 2

    Noninvasive bioluminescence imaging of normal and spontaneously transformed prostate tissue in mice by LYONS, Scott K, LIM, Ed, JENKINS, Darlene, CLERMONT, Anne O, DUSICH, Joan, LINGYUN ZHU, CAMPBELL, Kenneth D, COFFEE, Richard J, GRASS, David S, HUNTER, John, PURCHIO, Tony

    Published in Cancer research (Chicago, Ill.) (01-05-2006)
    “…Several transgenic mouse models of prostate cancer have been developed recently that are able to recapitulate many key biological features of the human…”
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    Journal Article
  3. 3

    A TRANSGENIC MOUSE MODEL WITH A LUCIFERASE REPORTER FOR STUDYING IN VIVO TRANSCRIPTIONAL REGULATION OF THE HUMAN CYP3A4 GENE by WEISHENG ZHANG, PURCHIO, Anthony F, CHEN, Kevin, JIANMING WU, LI LU, COFFEE, Richard, CONTAG, Pamela R, WEST, David B

    Published in Drug metabolism and disposition (01-08-2003)
    “…Cytochrome P450 3A4 (CYP3A4) plays an important role in drug metabolism, and the enzymatic activity of CYP3A4 contributes to many adverse drug-drug…”
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  4. 4

    DIFFERENTIAL REGULATION OF THE HUMAN CYP3A4 PROMOTER IN TRANSGENIC MICE AND RATS by WEISHENG ZHANG, PURCHIO, Anthony F, COFFEE, Richard, WEST, David B

    Published in Drug metabolism and disposition (01-02-2004)
    “…Previously we described a transgenic mouse model [FVB/NTg( CYP3A4-luc )Xen] using a reporter construct consisting of 13 kilobases of the human CYP3A4 promoter…”
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  5. 5

    Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters by Jiang, Weiwu, Wang, Lihua, Zhang, Weisheng, Coffee, Richard, Fazili, Inayat S., Moorthy, Bhagavatula

    “…There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens. Cytochrome P450 (CYP)1A enzymes play key…”
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  6. 6

    A Cyp1a2-Luciferase Transgenic CD-1 Mouse Model: Responses to Aryl Hydrocarbons Similar to the Humanized AhR Mice by Zhang, Weisheng, Moorthy, Bhagavatula, Chen, Min, Muthiah, Kathirvel, Coffee, Richard, Purchio, Anthony F., West, David B.

    Published in Toxicological sciences (01-11-2004)
    “…Here we describe a transgenic mouse model [Crl:CD-1(ICR)BR-Tg(Cyp1a2-luc)Xen] using luciferase as a reporter for Cyp1a2 gene regulation. An 8.4-kilobase mouse…”
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  7. 7

    Somatic Recombination of Heavy Chain Variable Region Transgenes with the Endogenous Immunoglobulin Heavy Chain Locus in Mice by Giusti, Angela M., Coffee, Richard, Manser, Tim

    “…Transgenic lines of mice were derived by using plasmid constructs containing DNA encoding an antibody heavy chain variable-diversity-joining region (VH-D-JH)…”
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    Journal Article
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