Search Results - "Coffee, Richard"
-
1
Non-invasive detection of a small number of bioluminescent cancer cells in vivo
Published in PloS one (23-02-2010)“…Early detection of tumors can significantly improve the outcome of tumor treatment. One of the most frequently asked questions in cancer imaging is how many…”
Get full text
Journal Article -
2
Noninvasive bioluminescence imaging of normal and spontaneously transformed prostate tissue in mice
Published in Cancer research (Chicago, Ill.) (01-05-2006)“…Several transgenic mouse models of prostate cancer have been developed recently that are able to recapitulate many key biological features of the human…”
Get full text
Journal Article -
3
A TRANSGENIC MOUSE MODEL WITH A LUCIFERASE REPORTER FOR STUDYING IN VIVO TRANSCRIPTIONAL REGULATION OF THE HUMAN CYP3A4 GENE
Published in Drug metabolism and disposition (01-08-2003)“…Cytochrome P450 3A4 (CYP3A4) plays an important role in drug metabolism, and the enzymatic activity of CYP3A4 contributes to many adverse drug-drug…”
Get full text
Journal Article -
4
DIFFERENTIAL REGULATION OF THE HUMAN CYP3A4 PROMOTER IN TRANSGENIC MICE AND RATS
Published in Drug metabolism and disposition (01-02-2004)“…Previously we described a transgenic mouse model [FVB/NTg( CYP3A4-luc )Xen] using a reporter construct consisting of 13 kilobases of the human CYP3A4 promoter…”
Get full text
Journal Article -
5
Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters
Published in Biochemical and biophysical research communications (25-12-2009)“…There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens. Cytochrome P450 (CYP)1A enzymes play key…”
Get full text
Journal Article -
6
A Cyp1a2-Luciferase Transgenic CD-1 Mouse Model: Responses to Aryl Hydrocarbons Similar to the Humanized AhR Mice
Published in Toxicological sciences (01-11-2004)“…Here we describe a transgenic mouse model [Crl:CD-1(ICR)BR-Tg(Cyp1a2-luc)Xen] using luciferase as a reporter for Cyp1a2 gene regulation. An 8.4-kilobase mouse…”
Get full text
Journal Article -
7
Somatic Recombination of Heavy Chain Variable Region Transgenes with the Endogenous Immunoglobulin Heavy Chain Locus in Mice
Published in Proceedings of the National Academy of Sciences - PNAS (01-11-1992)“…Transgenic lines of mice were derived by using plasmid constructs containing DNA encoding an antibody heavy chain variable-diversity-joining region (VH-D-JH)…”
Get full text
Journal Article -
8
Missa "Sunt bona mixta malis"
Published in The Choral Journal (01-08-1994)Get full text
Book Review -
9
COMPLEX: an Applesoft BASIC program to assess preference for visual complexity
Published in Behavior research methods, instruments, & computers (01-05-1984)Get full text
Journal Article