Search Results - "Coetzee, Lindi M"
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An integrated tiered service delivery model (ITSDM) based on local CD4 testing demands can improve turn-around times and save costs whilst ensuring accessible and scalable CD4 services across a national programme
Published in PloS one (09-12-2014)“…The South African National Health Laboratory Service (NHLS) responded to HIV treatment initiatives with two-tiered CD4 laboratory services in 2004. Increasing…”
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Estimating implementation and operational costs of an integrated tiered CD4 service including laboratory and point of care testing in a remote health district in South Africa
Published in PloS one (17-12-2014)“…An integrated tiered service delivery model (ITSDM) has been proposed to provide 'full-coverage' of CD4 services throughout South Africa. Five tiers are…”
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Screening HIV-Infected Patients with Low CD4 Counts for Cryptococcal Antigenemia prior to Initiation of Antiretroviral Therapy: Cost Effectiveness of Alternative Screening Strategies in South Africa
Published in PloS one (08-07-2016)“…In 2015 South Africa established a national cryptococcal antigenemia (CrAg) screening policy targeted at HIV-infected patients with CD4+ T-lymphocyte (CD4)…”
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Establishing the cost of Xpert MTB/RIF mobile testing in high-burden peri-mining communities in South Africa
Published in African journal of laboratory medicine (2021)“…Background: Globally, tuberculosis remains a major cause of mortality, with an estimated 1.3 million deaths per annum. The Xpert MTB/RIF assay is used as the…”
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Timely delivery of laboratory efficiency information, part I : developing an interactive turnaround time dashboard at a high-volume laboratory
Published in African journal of laboratory medicine (2020)“…Background: Mean turn-around time (TAT) reporting for testing laboratories in a national network is typically static and not immediately available for…”
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Timely delivery of laboratory efficiency information, part II : assessing the impact of a turn-around time dashboard at a high-volume laboratory
Published in African journal of laboratory medicine (2020)“…Background: In South Africa’s National Health Laboratory Service, ad hoc mean turn-around time (TAT) reporting is an important indicator of performance…”
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Performance of the PointCare NOW system for CD4 counting in HIV patients based on five independent evaluations
Published in PloS one (09-08-2012)“…Point-of-care (POC) CD4 testing can improve access to treatment by enabling decentralization and reducing patient loss-to-follow-up. As new POC CD4…”
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Addressing antiretroviral therapy-related diagnostic coverage gaps across South Africa using a programmatic approach
Published in African journal of laboratory medicine (2018)“…Background: A major challenge facing South Africa is the concomitant HIV and tuberculosis epidemics. The National Health Laboratory Service provides testing…”
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District and sub-district analysis of cryptococcal antigenaemia prevalence and specimen positivity in KwaZulu-Natal, South Africa
Published in African journal of laboratory medicine (2018)“…Background: Cryptococcal meningitis (CM) is a leading cause of mortality among HIVpositive South Africans. Reflex cryptococcal antigen (CrAg) testing of…”
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Programmatic implications of implementing the relational algebraic capacitated location (RACL) algorithm outcomes on the allocation of laboratory sites, test volumes, platform distribution and space requirements
Published in African journal of laboratory medicine (2017)“…Introduction: CD4 testing in South Africa is based on an integrated tiered service delivery model that matches testing demand with capacity. The National…”
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Compliance to HIV treatment monitoring guidelines can reduce laboratory costs
Published in Southern African journal of HIV medicine (2016)“…Panel tests are a predetermined group of tests commonly requested together to provide a comprehensive and conclusive diagnosis, for example, liver function…”
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Correction: Performance of the PointCare NOW System for CD4 Counting in HIV Patients Based on Five Independent Evaluations
Published in PloS one (19-09-2012)“…The SA NHLS is the sole owner of the PLG CD4 patent, and receives royalties related to licensing agreement with BC Miami. (2012) Correction: Performance of the…”
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Retrospective Assessment of a National Reflex Cryptococcal Antigen Screening Program in South Africa Through Interlaboratory Comparison of Lateral Flow Assay Results
Published in Laboratory medicine (03-11-2022)“…Abstract Objective Reflex cryptococcal antigen (CrAg) screening of blood specimens with a CD4 count of <100 cells/µL was performed at 45 South African CD4…”
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Performance evaluation of the Pima™ point‐of‐care CD4 analyser using capillary blood sampling in field tests in South Africa
Published in Journal of the International AIDS Society (30-01-2012)“…Background Point‐of‐care CD4 testing can provide immediate CD4 reporting at HIV‐testing sites. This study evaluated performance of capillary blood sampling…”
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Decentralised CD38 activation monitoring: Aspects of practical implementation and standardisation
Published in Journal of immunological methods (30-04-2012)“…In light of the HIV pandemic, significant strides have been made in improving treatment options for patients. Technologies to monitor the progress of a patient…”
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Siting of HIV/AIDS diagnostic equipment in South Africa: a case study in locational analysis
Published in International transactions in operational research (01-01-2018)“…This paper describes a practical application of locational analysis to the siting of HIV/AIDS diagnostic equipment in laboratories across South Africa…”
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A model for continuous quality control incorporating sample‐to‐sample assessment of optical alignment, fluorescence sensitivity, and volumetric operation of flow cytometers
Published in Cytometry. Part B, Clinical cytometry (01-05-2010)“…Background: Bead count rate (BCR) monitoring successfully identifies pipetting error during single platform CD4 enumeration. Despite rigorous prescribed…”
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From research tool to routine test: CD38 monitoring in HIV patients
Published in Cytometry. Part B, Clinical cytometry (01-11-2009)“…Background: CD38 expression on CD8+ T lymphocytes in HIV‐infected patients is monitored by flow cytometry (FCM). There is however no consensus re CD38…”
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Large‐scale affordable Panleucogated CD4+ testing with proactive internal and external quality assessment: In support of the South African national comprehensive care, treatment and management programme for HIV and AIDS
Published in Cytometry. Part B, Clinical cytometry (2008)“…Background: In order to expand the treatment of human immunodeficiency virus‐1 (HIV) infected patients in Africa, millions will require cost‐effective CD4…”
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