Search Results - "Coetzee, Lindi"
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An integrated tiered service delivery model (ITSDM) based on local CD4 testing demands can improve turn-around times and save costs whilst ensuring accessible and scalable CD4 services across a national programme
Published in PloS one (09-12-2014)“…The South African National Health Laboratory Service (NHLS) responded to HIV treatment initiatives with two-tiered CD4 laboratory services in 2004. Increasing…”
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Performance verification of the new fully automated Aquios flow cytometer PanLeucogate (PLG) platform for CD4-T-lymphocyte enumeration in South Africa
Published in PloS one (03-11-2017)“…The National Health Laboratory Service (NHLS) offers wide-scale CD4 testing through a network of laboratories in South Africa. A new "load and go" cytometer…”
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Using laboratory data to assess the impact of coronavirus (COVID-19) on reflex cryptococcal antigenaemia (CrAg) testing in South Africa
Published in PloS one (28-09-2023)“…Background Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, China. Due…”
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Performance Evaluation of the Becton Dickinson FACSPresto™ Near-Patient CD4 Instrument in a Laboratory and Typical Field Clinic Setting in South Africa
Published in PloS one (25-05-2016)“…The BD-FACSPresto™ CD4 is a new, point-of-care (POC) instrument utilising finger-stick capillary blood sampling. This study evaluated its performance against…”
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Estimating implementation and operational costs of an integrated tiered CD4 service including laboratory and point of care testing in a remote health district in South Africa
Published in PloS one (17-12-2014)“…An integrated tiered service delivery model (ITSDM) has been proposed to provide 'full-coverage' of CD4 services throughout South Africa. Five tiers are…”
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Screening HIV-Infected Patients with Low CD4 Counts for Cryptococcal Antigenemia prior to Initiation of Antiretroviral Therapy: Cost Effectiveness of Alternative Screening Strategies in South Africa
Published in PloS one (08-07-2016)“…In 2015 South Africa established a national cryptococcal antigenemia (CrAg) screening policy targeted at HIV-infected patients with CD4+ T-lymphocyte (CD4)…”
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Cryptococcal antigen positivity combined with the percentage of HIV-seropositive samples with CD4 counts <100 cells/μl identifies districts in South Africa with advanced burden of disease
Published in PloS one (12-06-2018)“…Cryptococcal meningitis (CM) is an opportunistic fungal disease with a high mortality among HIV-positive patients with severe immunosuppression (CD4 count <100…”
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Estimating the cost-per-result of a national reflexed Cryptococcal antigenaemia screening program: Forecasting the impact of potential HIV guideline changes and treatment goals
Published in PloS one (22-08-2017)“…During 2016, the National Health Laboratory Service (NHLS) introduced laboratory-based reflexed Cryptococcal antigen (CrAg) screening to detect early…”
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HiveLaw: Propelling the Nelson Mandela University Law Clinic into the Future: A Consideration of Technology's Integral Role in Modern Legal Service Delivery and the Consequences for Legal Education
Published in Potchefstroom electronic law journal (17-10-2024)“…The effective training of law students, which demystifies technology, and the creation of cost effective, fit for purpose technology solutions are crucial to…”
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Modelling CD4 reagent usage across a national hierarchal network of laboratories in South Africa
Published in African journal of laboratory medicine (2023)“…Background: The National Health Laboratory Service is mandated to deliver cost-effective and efficient diagnostic services across South Africa. Their mandate…”
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Establishing a cost-per-result of laboratory-based, reflex Cryptococcal antigenaemia screening (CrAg) in HIV+ patients with CD4 counts less than 100 cells/μl using a Lateral Flow Assay (LFA) at a typical busy CD4 laboratory in South Africa
Published in PloS one (2017)“…Cryptococcal meningitis is a major cause of mortality and morbidity in countries with high HIV prevalence, primarily affecting patients whose CD4 are < = 100…”
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Newly implemented community CD4 service in Tshwaragano, Northern Cape province, South Africa, positively impacts result turn-around time
Published in African journal of laboratory medicine (2022)“…Background The Northern Cape is South Africa’s largest province with an HIV prevalence of 7.1% versus a 13.5% national prevalence. CD4 testing is provided at…”
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Assessing very advanced HIV disease in adolescent girls and young women
Published in Southern African journal of HIV medicine (2023)“…South Africa has the largest HIV epidemic globally, with ~7.5 million people living with HIV in 2021. Adolescent girls (AG) and young women (YW), aged 15-19…”
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Performance evaluation of the Pima™ point‐of‐care CD4 analyser using capillary blood sampling in field tests in South Africa
Published in Journal of the International AIDS Society (30-01-2012)“…Background Point‐of‐care CD4 testing can provide immediate CD4 reporting at HIV‐testing sites. This study evaluated performance of capillary blood sampling…”
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Performance of the PointCare NOW system for CD4 counting in HIV patients based on five independent evaluations
Published in PloS one (09-08-2012)“…Point-of-care (POC) CD4 testing can improve access to treatment by enabling decentralization and reducing patient loss-to-follow-up. As new POC CD4…”
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Retrospective Assessment of a National Reflex Cryptococcal Antigen Screening Program in South Africa Through Interlaboratory Comparison of Lateral Flow Assay Results
Published in Laboratory medicine (03-11-2022)“…Abstract Objective Reflex cryptococcal antigen (CrAg) screening of blood specimens with a CD4 count of <100 cells/µL was performed at 45 South African CD4…”
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Weekly laboratory turn-around time identifies poor performance masked by aggregated reporting
Published in African journal of laboratory medicine (2020)“…Abstract only…”
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Using laboratory data to categorise CD4 laboratory turn-around-time performance across a national programme
Published in African journal of laboratory medicine (2018)“…Background and objective: The National Health Laboratory Service provides CD4 testing through an integrated tiered service delivery model with a target…”
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Establishing the cost of Xpert MTB/RIF mobile testing in high-burden peri-mining communities in South Africa
Published in African journal of laboratory medicine (2021)“…Background: Globally, tuberculosis remains a major cause of mortality, with an estimated 1.3 million deaths per annum. The Xpert MTB/RIF assay is used as the…”
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