Search Results - "Coetzee, Janetta"

Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics by Stappert, Moritz, Kohnhäuser, Daniel, Seedorf, Tim, Coetzee, Janetta, Rox, Katharina, Fuchs, Hazel L. S., Cirnski, Katarina, Leitner, Christian, Herrmann, Jennifer, Kirschning, Andreas, Müller, Rolf, Brönstrup, Mark

“…Novel scaffolds for broad-spectrum antibiotics are rare and in strong demand because of the increase in antimicrobial resistance. The cystobactamids,…”
Get full text

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa by Zscherp, Robert, Coetzee, Janetta, Vornweg, Johannes, Grunenberg, Jörg, Herrmann, Jennifer, Müller, Rolf, Klahn, Philipp

“…The design, synthesis and biological evaluation of the artificial enterobactin analogue and several fluorophore-conjugates thereof are described. provides an…”
Get full text

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry by Cirnski, Katarina, Coetzee, Janetta, Herrmann, Jennifer, Müller, Rolf

“…Due to the global threat of rising antimicrobial resistance, novel antibiotics are urgently needed. We investigate natural products from Myxobacteria as…”
Get more information

Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Over recent decades, the pipeline of antibiotics acting against Gram‐negative bacteria is running dry, as most discovered candidate antibiotics suffer from…”
Get full text

Optimization of the Central α‑Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861 by Kohnhäuser, Daniel, Seedorf, Tim, Cirnski, Katarina, Heimann, Dominik, Coetzee, Janetta, Sordello, Sylvie, Richter, Jana, Stappert, Moritz, Sabuco, Jean-Francois, Corbett, David, Bacqué, Eric, Rox, Katharina, Herrmann, Jennifer, Vassort, Aurelie, Müller, Rolf, Kirschning, Andreas, Brönstrup, Mark

“…Cystobactamids have a unique oligoarylamide structure and exhibit broad-spectrum activity against Gram-negative and Gram-positive bacteria. In this study, the…”
Get full text

Inside Cover: Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering (Angew. Chem. Int. Ed. 2/2023) by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM‐complex of Gram‐negative pathogens. The renewal of the outer membrane proteins…”
Get full text

Total synthesis and mechanism of action of the antibiotic armeniaspirol A by Arisetti, Nanaji, Fuchs, Hazel L. S, Coetzee, Janetta, Orozco, Manuel, Ruppelt, Dominik, Bauer, Armin, Heimann, Dominik, Kuhnert, Eric, Bhamidimarri, Satya P, Bafna, Jayesh A, Hinkelmann, Bettina, Eckel, Konstantin, Sieber, Stephan A, Müller, Peter P, Herrmann, Jennifer, Müller, Rolf, Winterhalter, Mathias, Steinem, Claudia, Brönstrup, Mark

“…Emerging antimicrobial resistance urges the discovery of antibiotics with unexplored, resistance-breaking mechanisms. Armeniaspirols represent a novel class of…”
Get full text

Innentitelbild: Darobactine mit Überlegener Antibiotischer Aktivität Generiert durch Strukturgeleitetes Kryo‐EM‐Biosynthese‐Design (Angew. Chem. 2/2023) by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM‐complex of Gram‐negative pathogens. The renewal of the outer membrane proteins…”
Get full text

Darobactine mit Überlegener Antibiotischer Aktivität Generiert durch Strukturgeleitetes Kryo‐EM‐Biosynthese‐Design by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…In den letzten Jahrzehnten ist die Entwicklungspipeline neuer Antibiotika gegen Gram‐negative Bakterien nahezu zum Erliegen gekommen, da die meisten entdeckten…”
Get full text

Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into and by Zscherp, Robert, Coetzee, Janetta, Vornweg, Johannes, Grunenberg, Jörg, Herrmann, Jennifer, Müller, Rolf, Klahn, Philipp

“…The design, synthesis and biological evaluation of the artificial enterobactin analogue Ent KL and several fluorophore-conjugates thereof are described. Ent KL…”
Get full text