Search Results - "Coers, Jorn"

Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions by Kutsch, Miriam, Sistemich, Linda, Lesser, Cammie F, Goldberg, Marcia B, Herrmann, Christian, Coers, Jörn

“…In the outer membrane of gram‐negative bacteria, O‐antigen segments of lipopolysaccharide (LPS) form a chemomechanical barrier, whereas lipid A moieties anchor…”
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins by Finethy, Ryan, Luoma, Sarah, Orench-Rivera, Nichole, Feeley, Eric M, Haldar, Arun K, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi, Kuehn, Meta J, Coers, Jörn

“…The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of…”
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Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles by Hernandez, Dulcemaria, Walsh, Stephen, Saavedra Sanchez, Luz, Dickinson, Mary S, Coers, Jörn

“…The obligate intracellular protozoan pathogen Toxoplasma gondii infects a wide range of vertebrate hosts and frequently causes zoonotic infections in humans…”
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Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses by Liu, Beiyun C., Sarhan, Joseph, Panda, Alexander, Muendlein, Hayley I., Ilyukha, Vladimir, Coers, Jörn, Yamamoto, Masahiro, Isberg, Ralph R., Poltorak, Alexander

“…Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed…”
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The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation by Bastidas, Robert J, Kędzior, Mateusz, Davidson, Robert K, Walsh, Stephen C, Dolat, Lee, Sixt, Barbara S, Pruneda, Jonathan N, Coers, Jörn, Valdivia, Raphael H

“…Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of…”
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The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs by Sixt, Barbara S., Bastidas, Robert J., Finethy, Ryan, Baxter, Ryan M., Carpenter, Victoria K., Kroemer, Guido, Coers, Jörn, Valdivia, Raphael H.

“…Evading cell death is critical for Chlamydia to maintain a replicative niche, but the underlying mechanisms are unknown. We screened a library of Chlamydia…”
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Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases by Biering, Scott B., Choi, Jayoung, Halstrom, Rachel A., Brown, Hailey M., Beatty, Wandy L., Lee, Sanghyun, McCune, Broc T., Dominici, Erin, Williams, Lelia E., Orchard, Robert C., Wilen, Craig B., Yamamoto, Masahiro, Coers, Jörn, Taylor, Gregory A., Hwang, Seungmin

“…All viruses with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replication complexes (RCs). RCs provide an advantageous…”
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Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems by Feeley, Eric M., Pilla-Moffett, Danielle M., Zwack, Erin E., Piro, Anthony S., Finethy, Ryan, Kolb, Joseph P., Martinez, Jennifer, Brodsky, Igor E., Coers, Jörn

“…Many invasive bacteria establish pathogen-containing vacuoles (PVs) as intracellular niches for microbial growth. Immunity to these infections is dependent on…”
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IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins by Haldar, Arun K, Saka, Hector A, Piro, Anthony S, Dunn, Joe Dan, Henry, Stanley C, Taylor, Gregory A, Frickel, Eva M, Valdivia, Raphael H, Coers, Jörn

“…Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic…”
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The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction by Walsh, Stephen C., Reitano, Jeffrey R., Dickinson, Mary S., Kutsch, Miriam, Hernandez, Dulcemaria, Barnes, Alyson B., Schott, Benjamin H., Wang, Liuyang, Ko, Dennis C., Kim, So Young, Valdivia, Raphael H., Bastidas, Robert J., Coers, Jörn

“…Chlamydia trachomatis is the leading cause of sexually transmitted bacterial infections and a major threat to women’s reproductive health in particular. This…”
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Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility by Piro, Anthony S, Hernandez, Dulcemaria, Luoma, Sarah, Feeley, Eric M, Finethy, Ryan, Yirga, Azeb, Frickel, Eva M, Lesser, Cammie F, Coers, Jörn

“…Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial…”
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Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock by Finethy, Ryan, Dockterman, Jacob, Kutsch, Miriam, Orench‐Rivera, Nichole, Wallace, Graham D, Piro, Anthony S, Luoma, Sarah, Haldar, Arun K, Hwang, Seungmin, Martinez, Jennifer, Kuehn, Meta J, Taylor, Gregory A, Coers, Jörn

“…Inflammation associated with gram‐negative bacterial infections is often instigated by the bacterial cell wall component lipopolysaccharide (LPS). LPS‐induced…”
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The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence by Pensinger, Daniel A, Boldon, Kyle M, Chen, Grischa Y, Vincent, William J B, Sherman, Kyle, Xiong, Meng, Schaenzer, Adam J, Forster, Emily R, Coers, Jörn, Striker, Rob, Sauer, John-Demian

“…Obstacles to bacterial survival and replication in the cytosol of host cells, and the mechanisms used by bacterial pathogens to adapt to this niche are not…”
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Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components by Zwack, Erin E, Feeley, Eric M, Burton, Amanda R, Hu, Baofeng, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi, Bliska, James B, Coers, Jörn, Brodsky, Igor E

“…Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate…”
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IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila by Price, Jordan V, Russo, Daniel, Ji, Daisy X, Chavez, Roberto A, DiPeso, Lucian, Lee, Angus Yiu-Fai, Coers, Jörn, Vance, Russell E

“…Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance…”
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Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation by Goers, Lisa, Kim, Kyungsub, Stedman, Teagan C, Canning, Patrick J, Mou, Xiangyu, Ernst, Nadja Heinz, Coers, Jörn, Lesser, Cammie F

“…Pyroptosis is an inflammatory form of cell death induced upon recognition of invading microbes. During an infection, pyroptosis is enhanced in…”
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A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins by Kohler, Kristin M, Kutsch, Miriam, Piro, Anthony S, Wallace, Graham D, Coers, Jörn, Barber, Matthew F

“…Cell-autonomous immunity relies on the rapid detection of invasive pathogens by host proteins. Guanylate binding proteins (GBPs) have emerged as key mediators…”
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A binary module for microbiota-mediated regulation of γδ17 cells, hallmarked by microbiota-driven expression of programmed cell death protein 1 by Huang, Hsin-I, Xue, Yue, Jewell, Mark L., Tan, Chin Yee, Theriot, Barbara, Aggarwal, Nupur, Dockterman, Jacob, Lin, Yang-Ding, Schroeder, Erin A., Wang, Donghai, Xiong, Na, Coers, Jörn, Shinohara, Mari L., Surana, Neeraj K., Hammer, Gianna Elena

“…Little is known about how microbiota regulate innate-like γδ T cells or how these restrict their effector functions within mucosal barriers, where microbiota…”
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An ancestral mycobacterial effector promotes dissemination of infection by Saelens, Joseph W., Sweeney, Mollie I., Viswanathan, Gopinath, Xet-Mull, Ana María, Jurcic Smith, Kristen L., Sisk, Dana M., Hu, Daniel D., Cronin, Rachel M., Hughes, Erika J., Brewer, W. Jared, Coers, Jörn, Champion, Matthew M., Champion, Patricia A., Lowe, Craig B., Smith, Clare M., Lee, Sunhee, Stout, Jason E., Tobin, David M.

“…The human pathogen Mycobacterium tuberculosis typically causes lung disease but can also disseminate to other tissues. We identified a M. tuberculosis (Mtb)…”
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Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells by Haldar, Arun K, Piro, Anthony S, Finethy, Ryan, Espenschied, Scott T, Brown, Hannah E, Giebel, Amanda M, Frickel, Eva-Maria, Nelson, David E, Coers, Jörn

“…The cytokine gamma interferon (IFN-γ) induces cell-autonomous immunity to combat infections with intracellular pathogens, such as the bacterium Chlamydia…”
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