Search Results - "Coenraad Hemker, H"

Thrombin generation: What have we learned? by Al Dieri, Raed, de Laat, Bas, Hemker, H. Coenraad

“…Abstract Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of thrombin appears after a lag time. Clotting occurs at…”
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Data management in Thrombin Generation by Hemker, H. Coenraad, Kremers, R

“…Abstract To obtain a thrombin generation (TG) curve from the conversion of added fluorogenic substrate, thrombin concentrations are to be derived from the…”
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Thrombin generation, a function test of the haemostatic-thrombotic system by Hemker, H Coenraad, Al Dieri, Raed, De Smedt, Erik, Béguin, Suzette

“…By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG)…”
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Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate? by Cate, Hugo, Hemker, H. Coenraad

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Thrombin generation: biochemical possibilities and clinical reality by Hemker, H. Coenraad

“…In this issue of Blood, under the unassuming title “Sample conditions determine the ability of thrombin generation parameters to identify bleeding phenotype in…”
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Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis by Wildhagen, Karin C.A.A., García de Frutos, Pablo, Reutelingsperger, Chris P., Schrijver, Roy, Aresté, Cristina, Ortega-Gómez, Almudena, Deckers, Niko M., Hemker, H. Coenraad, Soehnlein, Oliver, Nicolaes, Gerry A.F.

“…Extracellular histones are considered to be major mediators of death in sepsis. Although sepsis is a condition that may benefit from low-dose heparin…”
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Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis by Hulshof, Anne-Marije, Hemker, H Coenraad, Spronk, Henri M H, Henskens, Yvonne M C, Ten Cate, Hugo

“…Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a…”
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Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis by Kremers, Romy M W, Kleinegris, Marie-Claire, Ninivaggi, Marisa, de Laat, Bas, Ten Cate, Hugo, Koek, Ger H, Wagenvoord, Rob J, Hemker, H Coenraad

“…Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or…”
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Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation by Bloemen, Saartje, Hemker, H Coenraad, Al Dieri, Raed

“…Anticoagulation by a standard dosage of an inhibitor of thrombin generation presupposes predictable pharmacokinetics and pharmacodynamics of the anticoagulant…”
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Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions by Kelchtermans, Hilde, Pelkmans, Leonie, Bouwhuis, Anne, Schurgers, Evelien, Lindhout, Theo, Huskens, Dana, Miszta, Adam, Hemker, H Coenraad, Lancé, Marcus D, de Laat, Bas

“…Assays based on the formation of thrombin and fibrin are frequently used, and results are considered exchangeable in research/clinical settings. However,…”
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Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B by Dargaud, Yesim, Béguin, Suzette, Lienhart, Anne, Al Dieri, Raed, Trzeciak, Christine, Bordet, Jean Claude, Hemker, H Coenraad, Negrier, Claude

“…In haemophilia patients, a relationship is usually observed between the clinical expression of the disease and plasmatic factor VIII/factor IX (FVIII/FIX)…”
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Thrombin generation in low plasma volumes by Bloemen, Saartje, Kelchtermans, Hilde, Hemker, H Coenraad

“…Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half,…”
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A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding by Kremers, Romy M W, Bosch, Yvonne P J, Bloemen, Saartje, de Laat, Bas, Weerwind, Patrick W, Mochtar, Bas, Maessen, Jos G, Wagenvoord, Rob J, Al Dieri, Raed, Hemker, H Coenraad

“…Cardiac surgery with cardiopulmonary bypass (CPB) is associated with blood loss and post-surgery thrombotic complications. The process of thrombin generation…”
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Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation by Kremers, Romy M W, Wagenvoord, Rob J, Hemker, H Coenraad

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Heparins: A Shift of Paradigm by Hemker, H Coenraad, Al Dieri, Raed, Béguin, Suzette

“…Heparins inhibit the thrombin forming capacity of plasma, i. e., the endogenous thrombin potential (ETP), by their anti-thrombin (aIIa) activity, the…”
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Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups by Kremers, Romy M W, Mohamed, Abdulrahman B O, Pelkmans, Leonie, Hindawi, Salwa, Hemker, H Coenraad, de Laat, H Bas, Huskens, Dana, Al Dieri, Raed

“…Individuals with blood group O have a higher bleeding risk than non-O blood groups. This could be explained by the lower levels of FVIII and von Willebrand…”
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Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin by Kremers, Romy M.W., Zuily, Stéphane, Kelchtermans, Hilde, Peters, Tessa C., Bloemen, Saartje, Regnault, Véronique, Hemker, H. Coenraad, de Groot, Philip G., Wahl, Denis, de Laat, Bas

“…Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia…”
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The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding by Al Dieri, Raed, Peyvandi, Flora, Santagostino, Elena, Giansily, Muriel, Mannucci, Pier Mannuccio, Schved, Jean François, Béguin, Suzette, Hemker, H Coenraad

“…We investigated the relation between clotting factor concentration, the parameters of the thrombin generation curve (the thrombogram) and the severity of…”
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Calibrated automated thrombin generation measurement in clotting plasma by Hemker, H Coenraad, Giesen, Peter, Al Dieri, Raed, Regnault, Véronique, de Smedt, Eric, Wagenvoord, Rob, Lecompte, Thomas, Béguin, Suzette

“…Calibrated automated thrombography displays the concentration of thrombin in clotting plasma with or without platelets (platelet-rich plasma/platelet-poor…”
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The initiation phase--a review of old (clotting-) times by Hemker, H Coenraad

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