Search Results - "Coelho Castelo, A. A. M."

Detrimental Effect of Fungal 60-kDa Heat Shock Protein on Experimental Paracoccidioides brasiliensis Infection by Fernandes, Fabrício Freitas, Oliveira, Leandro Licursi de, Landgraf, Taise Natali, Peron, Gabriela, Costa, Marcelo Vieira, Coelho-Castelo, Arlete A M, Bonato, Vânia L D, Roque-Barreira, Maria-Cristina, Panunto-Castelo, Ademilson

“…The genus Paracoccidioides comprises species of dimorphic fungi that cause paracoccidioidomycosis (PCM), a systemic disease prevalent in Latin America. Here,…”
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B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization by Fontoura, I C, Trombone, A P F, Almeida, L P, Lorenzi, J C C, Rossetti, R A M, Malardo, T, Padilha, E, Schluchting, W, Silva, R L L, Gembre, A F, Fiuza, J E C, Silva, C L, Panunto-Castelo, A, Coelho-Castelo, A A M

“…In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells…”
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Functional interferences in host inflammatory immune response by airway allergic inflammation restrain experimental periodontitis development in mice by da Fonseca, Denise Morais, Trombone, Ana Paula Fávaro, Repeke, Carlos Eduardo, Avila-Campos, Mario Julio, Coelho-Castelo, Arlete A. M., Silva, João Santana, Campanelli, Ana Paula, Deperon Bonato, Vânia Luiza, Garlet, Gustavo Pompermaier

“…da Fonseca DM, Trombone APF, Repeke CE, Avila‐Campos MJ, Coelho‐Castelo AAM, Silva JS, Campanelli AP, Bonato VLD, Garlet GP. Functional interferences in host…”
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HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis by Ribeiro, Alice M, Bocca, Anamelia L, Amaral, André C, Souza, Ana Camila C.O, Faccioli, Lúcia H, Coelho-Castelo, Arlete A.M, Figueiredo, Florêncio, Silva, Célio L, Felipe, Maria Sueli S

“…Abstract The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in…”
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Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation by Trombone, Ana Paula F, Silva, Célio L, Lima, Karla M, Oliver, Constance, Jamur, Maria Célia, Prescott, Alan R, Coelho-Castelo, Arlete A M

“…Experimental models using DNA vaccine has shown that this vaccine is efficient in generating humoral and cellular immune responses to a wide variety of…”
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Intranasal vaccination with messenger RNA as a new approach in gene therapy: use against tuberculosis by Lorenzi, Julio C C, Trombone, Ana P F, Rocha, Carolina D, Almeida, Luciana P, Lousada, Ricardo L, Malardo, Thiago, Fontoura, Isabela C, Rossetti, Renata A M, Gembre, Ana F, Silva, Aristóbolo M, Silva, Celio L, Coelho-Castelo, Arlete A M

“…mRNAs are highly versatile, non-toxic molecules that are easy to produce and store, which can allow transient protein expression in all cell types. The safety…”
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Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes by Rosada, Rogério S, de la Torre, Lucimara Gaziola, Frantz, Fabiani G, Trombone, Ana P F, Zárate-Bladés, Carlos R, Fonseca, Denise M, Souza, Patrícia R M, Brandão, Izaíra T, Masson, Ana P, Soares, Edson G, Ramos, Simone G, Faccioli, Lúcia H, Silva, Célio L, Santana, Maria H A, Coelho-Castelo, Arlete A M

“…The greatest challenges in vaccine development include optimization of DNA vaccines for use in humans, creation of effective single-dose vaccines, development…”
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Immune modulation induced by tuberculosis DNA vaccine protects non‐obese diabetic mice from diabetes progression by Rodrigues dos Santos, R., Sartori, A., Deperon Bonato, V. L., Coelho Castelo, A. A. M., Vilella, C. A., Zollner, R. L., Lopes Silva, C.

“…Summary We have described previously the prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65 kDa heat shock protein…”
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Low-dose plasmid DNA treatment increases plasma vasopressin and regulates blood pressure in experimental endotoxemia by Malardo, Thiago, Batalhão, Marcelo E, Panunto-Castelo, Ademilson, Almeida, Luciana P, Padilha, Everton, Fontoura, Isabela C, Silva, Célio L, Carnio, Evelin C, Coelho-Castelo, Arlete A M

“…Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as…”
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Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice by SILVA, C. L, BONATO, V. L. D, COELHO-CASTELO, A. A. M, DE SOUZA, A. O, SANTOS, S. A, LIMA, K. M, FACCIOLI, L. H, RODRIGUES, J. M

“…Tuberculosis (TB) remains a threat for public health, killing around 3 million people a year. Despite the fact that most cases can be cured with antibiotics,…”
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B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization by I. C. Fontoura, A.P.F. Trombone, L. P. Almeida, J. C. C. Lorenzi, R. A. M. Rossetti, T. Malardo, E. Padilha, W. Schluchting, R. L. L. Silva, A. F. Gembre, J. E. C. Fiuza, C. L. Silva, A. Panunto-Castelo, A. A. M. Coelho-Castelo

“…In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells…”
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Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis by LIMA, K. M, SANTOS, S. A, LIMA, V. M. F, COELHO-CASTELO, A. A. M, RODRIGUES, J. M, SILVA, C. L

“…The high incidence of tuberculosis around the world and the inability of BCG to protect certain populations clearly indicate that an improved vaccine against…”
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Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin by Lourenço, E V, Pereira, S R, Faça, V M, Coelho-Castelo, A A, Mineo, J R, Roque-Barreira, M C, Greene, L J, Panunto-Castelo, A

“…Host cell invasion by Toxoplasma gondii is a multistep process with one of the first steps being the apical release of micronemal proteins that interact with…”
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Protective efficacy of different strategies employing Mycobacterium leprae heat-shock protein 65 against tuberculosis by Souza, Patrícia R M, Zárate-Bladés, Carlos R, Hori, Juliana I, Ramos, Simone G, Lima, Deison S, Schneider, Tatiana, Rosada, Rogério S, Torre, Lucimara G L, Santana, Maria Helena A, Brandão, Izaíra T, Masson, Ana P, Coelho-Castelo, Arlete A M, Bonato, Vânia L, Galetti, Fabio C S, Gonçalves, Eduardo D, Botte, Domingos A, Machado, Jeanne B M, Silva, Celio L

“…Tuberculosis is a major threat to human health. The high disease burden remains unaffected and the appearance of extremely drug-resistant strains in different…”
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The synergy between structural stability and DNA-binding controls the antibody production in EPC/DOTAP/DOPE liposomes and DOTAP/DOPE lipoplexes by de la Torre, Lucimara Gaziola, Rosada, Rogério Silva, Trombone, Ana Paula Fávaro, Frantz, Fabiani Gai, Coelho-Castelo, Arlete A.M., Silva, Celio Lopes, Santana, Maria Helena Andrade

“…We present a comparative study of the physico-chemical properties, in vitro cytotoxicity and in vivo antibody production of surface-complexed DNA in…”
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Immune regulatory effect of pHSP65 DNA therapy in pulmonary tuberculosis: activation of CD8+ cells, interferon‐γ recovery and reduction of lung injury by Bonato, V. L. D., Gonçalves, E. D. C., Soares, E. G., Júnior, R. R. Santos, Sartori, A., Coelho‐Castelo, A. A. M., Silva, C. L.

“…Summary A DNA vaccine based on the heat‐shock protein 65 Mycobacterium leprae gene (pHSP65) presented a prophylactic and therapeutic effect in an experimental…”
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Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis by Rocha, C D, Trombone, A P F, Lorenzi, J C C, Almeida, L P, Gembre, A F, Padilha, E, Ramos, S G, Silva, C L, Coelho-Castelo, A A M

“…In the last several years, the use of dendritic cells has been studied as a therapeutic strategy against tumors. Dendritic cells can be pulsed with peptides or…”
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Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis by Santos-Junior, Rubens R, Sartori, Alexandrina, De Franco, Marcelo, Filho, Orlando G R, Coelho-Castelo, Arlete A M, Bonato, Vânia L D, Cabrera, Wafa H K, Ibañez, Olga M, Silva, Célio L

“…We described a prophylactic and therapeutic effect of a DNA vaccine encoding the Mycobacterium leprae 65-kDa heat shock protein (DNA-hsp65) in experimental…”
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B-lymphocytes in bone marrow or lymph nodes can take up plasmid DNA after intramuscular delivery by Coelho-Castelo, Arlete A M, Santos Júnior, Rubens R, Bonato, Vânia L D, Jamur, Maria Célia, Oliver, Constance, Silva, Célio Lopes

“…Nucleic acid vaccines are an attractive alternative to conventional protein vaccines because of their ability to induce de novo production of antigens in a…”
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Cytotoxic T cells and mycobacteria by Silva, Celio L., Bonato, Vania L.D., Lima, Karla M., Coelho-Castelo, Arlete A.M., Faccioli, Lúcia H., Sartori, Alexandrina, De Souza, Ana O., Leão, Sylvia C.

“…Abstract How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated…”
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