Search Results - "Coelho, Laura Lacerda"
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Current Understanding of Human Polymorphism in Selenoprotein Genes: A Review of Its Significance as a Risk Biomarker
Published in International journal of molecular sciences (01-02-2024)“…Selenium has been proven to influence several biological functions, showing to be an essential micronutrient. The functional studies demonstrated the benefits…”
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Exploring the Dimensions of Pre-Clinical Research: 3D Cultures as an Investigative Model of Cardiac Fibrosis in Chagas Disease
Published in Biomedicines (25-06-2024)“…A three-dimensional (3D) cell culture can more precisely mimic tissues architecture and functionality, being a promising alternative model to study disease…”
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Clinical trials for Chagas disease: etiological and pathophysiological treatment
Published in Frontiers in microbiology (2023)“…Chagas disease (CD) is caused by the flagellate protozoan . It is endemic in Latin America. Nowadays around 6 million people are affected worldwide, and 75…”
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Vascular Growth Factor Inhibition with Bevacizumab Improves Cardiac Electrical Alterations and Fibrosis in Experimental Acute Chagas Disease
Published in Biology (Basel, Switzerland) (01-11-2023)“…Chagas disease (CD) caused by Trypanosoma cruzi is a neglected illness and a major reason for cardiomyopathy in endemic areas. The existing therapy generally…”
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Unveiling Lovastatin's Anti-Inflammatory Potential in Mouse's Brain during Acute Trypanosoma cruzi Infection
Published in Biology (Basel, Switzerland) (27-04-2024)“…Neurological commitment is a neglected manifestation of Chagas disease (CD). Meningoencephalitis mainly affects children and immunosuppressed patients, while…”
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Spheroid Model of Mammary Tumor Cells: Epithelial-Mesenchymal Transition and Doxorubicin Response
Published in Biology (Basel, Switzerland) (21-06-2024)“…Breast cancer is the most prevalent cancer among women worldwide. Therapeutic strategies to control tumors and metastasis are still challenging…”
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Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins
Published in Parasites & vectors (30-01-2018)“…Cardiac fibrosis is a consequence of chronic chagasic cardiomyopathy (CCC). In other cardiovascular diseases, the protagonist role of fibroblasts in cardiac…”
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Unveiling Lovastatin’s Anti-Inflammatory Potential in Mouse’s Brain during Acute ITrypanosoma cruzi/I Infection
Published in Biology (Basel, Switzerland) (01-05-2024)“…Cerebral alterations have been identified in Chagas disease since its discovery. Meningoencephalitis and stroke were verified in patients and experimental…”
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Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection
Published in Memórias do Instituto Oswaldo Cruz (01-01-2022)“…Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in Chagas disease (CD) physiopathology is unclear. The…”
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