Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy

Abstract Objective To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital. Methods A cross-sectional study was conducted of pregnant women infected with H1N1 who were admi...

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Published in:	International journal of gynecology and obstetrics Vol. 116; no. 3; pp. 214 - 218
Main Authors:	Figueiró-Filho, Ernesto A, Oliveira, Myrna L.G, Pompilio, Maurício A, Uehara, Silvia N.O, Coelho, Lílian R, De Souza, Bruno A, Breda, Ili
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-03-2012 Elsevier
Subjects:	Adolescent Adult Antiviral Agents - therapeutic use Biological and medical sciences Brazil Brazil - epidemiology Cross-Sectional Studies Delivery. Postpartum. Lactation Female Gynecology. Andrology. Obstetrics H1N1 virus Humans Infectious diseases Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - diagnosis Influenza, Human - drug therapy Influenza, Human - epidemiology Maternal and child health Maternal Mortality Medical sciences Obstetrics and Gynecology Oseltamivir - therapeutic use Pandemics Perinatal Mortality Pregnancy Pregnancy complications Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - epidemiology Pregnancy Outcome Treatment Outcome Viral diseases Young Adult South America Brazil America H1N1 virus Pregnancy Brazil Maternal and child health Pregnancy complications Human Gynecology Perinatal Obstetrics Infection Virus Treatment Mother Viral disease Complication Delivery Child Public health
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Summary:	Abstract Objective To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital. Methods A cross-sectional study was conducted of pregnant women infected with H1N1 who were admitted to the University Hospital at the School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, during the 2009 pandemic. Data were obtained via a questionnaire, which was administered during the hospital evaluation of patients’ medical records. Results Thirty-one patients were included in the study. Antiviral therapy was initiated within 48 hours of the onset of symptoms in 64.5% of cases. Infection with the H1N1 virus was associated with severe clinical complications in 22.6% of patients and adverse perinatal outcomes in 41.9% of cases. The rate of maternal and perinatal mortality was 9.7%. There was a statistically significant association between late treatment with oseltamivir and increase in systemic complications in pregnancy (odds ratio 22.80 [95% confidence interval, 2.20–235.65]; P = 0.007). Conclusion Early treatment with oseltamivir may prevent serious complications associated with H1N1 infection in pregnant women but it does not affect perinatal outcome.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7292 1879-3479
DOI:	10.1016/j.ijgo.2011.10.026