Hyperbaric oxygen therapy effects on tissue lesions in acute pancreatitis. Experimental study in rats

Hyperbaric oxygen therapy effects on tissue lesions in acute pancreatitis. Experimental study in rats

To study the effects of hyperbaric oxygen therapy on tissue lesions in an experimental model of acute pancreatitis induced by pancreatic duct ligation. Forty-eight adult female Wistar rats were randomized into two groups (n=24): control group and hyperbaric oxygen therapy group. The second group was...

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Bibliographic Details
Published in:Journal of the Pancreas Vol. 9; no. 3; pp. 275 - 282
Main Authors: Festugato, Marcio, Coelho, Celso Picolli, Fiedler, Gustavo, Machado, Felipe Pioner, Gonçalves, Mauro Cabral, Bassani, Filipe Rech, Pierezan, Paulo Henrique, Osvaldt, Alessandro Bersch, Rohde, Luiz
Format: Journal Article
Language:English
Published: Italy 08-05-2008
Subjects:
Acute Disease
Amylases - metabolism
Animals
Disease Models, Animal
Female
Hemorrhage - diagnosis
Hyperbaric Oxygenation
Necrosis - diagnosis
Pancreatitis - metabolism
Pancreatitis - pathology
Pancreatitis - therapy
Rats
Rats, Wistar
Research Design
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Summary:To study the effects of hyperbaric oxygen therapy on tissue lesions in an experimental model of acute pancreatitis induced by pancreatic duct ligation. Forty-eight adult female Wistar rats were randomized into two groups (n=24): control group and hyperbaric oxygen therapy group. The second group was treated with a two-hour daily session of hyperbaric oxygen therapy at 2.5 ATA started 6 hours after pancreatic duct ligation. The two groups were divided into 3 subgroups of 8 rats each undergoing euthanasia on days 1, 3, and 7 after the acute pancreatitis induction. The pancreas was evaluated according to the following histopathologic criteria: edema, hemorrhage, acinar necrosis and leukocyte infiltration. Hyperbaric oxygen therapy was efficient in significantly reducing acinar necrosis on the first day (P=0.049) and the foci of hemorrhage on the seventh day (P=0.050). The edema and leukocyte infiltration did not show the expected reduction. The utilization of a daily session of hyperbaric oxygen therapy at 2.5 ATA is efficient in reducing the hemorrhage and acinar necrosis but is not sufficient to reduce edema and leukocyte infiltration.
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ISSN:1590-8577