Search Results - "Coelewij, Leda"

Mini‐review: Update on the genetics of schizophrenia by Coelewij, Leda, Curtis, David

“…A number of important findings have recently emerged relevant to identifying genetic risk factors for schizophrenia. Findings using common variants point…”
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Using Serum Metabolomics to Predict Development of Anti-drug Antibodies in Multiple Sclerosis Patients Treated With IFNβ by Waddington, Kirsty E, Papadaki, Artemis, Coelewij, Leda, Adriani, Marsilio, Nytrova, Petra, Kubala Havrdova, Eva, Fogdell-Hahn, Anna, Farrell, Rachel, Dönnes, Pierre, Pineda-Torra, Inés, Jury, Elizabeth C

“…Neutralizing anti-drug antibodies (ADA) can greatly reduce the efficacy of biopharmaceuticals used to treat patients with multiple sclerosis (MS). However, the…”
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Impact of immunogenicity on clinical efficacy and toxicity profile of biologic agents used for treatment of inflammatory arthritis in children compared to adults by Parikh, Chinar R., Ponnampalam, Jaya K., Seligmann, George, Coelewij, Leda, Pineda-Torra, Ines, Jury, Elizabeth C., Ciurtin, Coziana

“…The treatment of inflammatory arthritis has been revolutionised by the introduction of biologic treatments. Many biologic agents are currently licensed for use…”
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Blood metabolomic and transcriptomic signatures stratify patient subgroups in multiple sclerosis according to disease severity by Oppong, Alexandra E., Coelewij, Leda, Robertson, Georgia, Martin-Gutierrez, Lucia, Waddington, Kirsty E., Dönnes, Pierre, Nytrova, Petra, Farrell, Rachel, Pineda-Torra, Inés, Jury, Elizabeth C.

“…There are no blood-based biomarkers distinguishing patients with relapsing-remitting (RRMS) from secondary progressive multiple sclerosis (SPMS) although…”
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Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology by Curtis, David, Coelewij, Leda, Liu, Shou-Hwa, Humphrey, Jack, Mott, Richard

“…A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in…”
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Dysregulated lipid metabolism networks modulate T-cell function in people with relapsing-remitting multiple sclerosis by Martin-Gutierrez, Lucia, Waddington, Kirsty E, Maggio, Annalisa, Coelewij, Leda, Oppong, Alexandra E, Yang, Nina, Adriani, Marsilio, Nytrova, Petra, Farrell, Rachel, Pineda-Torra, Inés, Jury, Elizabeth C

“…Altered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with…”
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Patients with multiple sclerosis who develop immunogenicity to interferon-beta have distinct transcriptomic and proteomic signatures prior to treatment which are associated with disease severity by Coelewij, Leda, Adriani, Marsilio, Dönnes, Pierre, Waddington, Kirsty E., Ciurtin, Coziana, Havrdova, Eva Kubala, Farrell, Rachel, Nytrova, Petra, Pineda-Torra, Inés, Jury, Elizabeth C.

“…Anti-drug antibodies (ADA) reduce the efficacy of immunotherapies in multiple sclerosis (MS) and are associated with increased disease progression risk. Blood…”
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Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus by Coelewij, Leda, Waddington, Kirsty E., Robinson, George A., Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Dönnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C., Pineda-Torra, Ines

“…[Figure: see text]…”
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Using Metabolomic and Transcriptomic Profiles to Predict Development of Anti-Drug Antibodies in People with Relapsing Remitting Multiple Sclerosis by Coelewij, Leda Maria Giuseppina

“…Background: Anti-drug antibodies (ADA) can greatly reduce the efficacy of immunotherapies in people affected by multiple sclerosis (MS). Immunogenicity risk…”
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Serum metabolomic signatures can predict sub-clinical atherosclerosis in patients with SLE by Coelewij, Leda, Waddington, Kirsty E, Robinson, George A, Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Dönnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C, Pineda-Torra, Ines

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Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus by Coelewij, Leda, Waddington, Kirsty E., Robinson, George A., Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Donnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C., Pineda-Torra, Ines

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Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE by Robinson, George A., Waddington, Kirsty E., Coelewij, Leda, Peng, Junjie, Naja, Meena, Wincup, Chris, Radziszewska, Anna, Peckham, Hannah, Isenberg, David A., Ioannou, Yiannis, Ciurtin, Coziana, Pineda-Torra, Ines, Jury, Elizabeth C.

“…Cardiovascular disease is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE). Traditional factors for…”
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P171 Cardiovascular risk in young patients with lupus: investigating metabolic biomarkers and the immunological phenotype by Robinson, George, Waddington, Kirsty, Coelewij, Leda, Peng, Junjie, Radziszewska, Anna, Wincup, Chris, Peckham, Hannah, Isenberg, David, Ioannou, Yiannis, Pineda-Torra, Ines, Ciurtin, Coziana, Jury, Elizabeth

“…BackgroundCardiovascular disease is the leading cause of mortality in patients with Juvenile-onset Systemic Lupus Erythematosus (JSLE) not attributable to…”
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