Search Results - "Coecke, S."

Biotransformation: A bottleneck in in vitro toxicology by Coecke, S.

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EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity by Bessems, J., Coecke, S., Gouliarmou, V., Whelan, M., Worth, A.

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Standardisation of ADME in vitro methods aimed for human risk assessment: The case of human hepatic metabolic clearance by Coecke, S., Gouliarmou, V., Bessems, J., Worth, A., Morath, S., Whelan, M.

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Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity by Gartlon, J., Kinsner, A., Bal-Price, A., Coecke, S., Clothier, R.H.

“…The European Commission White Paper, “Strategy for a future chemicals policy” (EC, 2001) is estimated to require the testing of approximately 30,000 ‘existing’…”
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The use of metabolising systems for in vitro testing of endocrine disruptors by Jacobs, M N, Janssens, W, Bernauer, U, Brandon, E, Coecke, S, Combes, R, Edwards, P, Freidig, A, Freyberger, A, Kolanczyk, R, Mc Ardle, C, Mekenyan, O, Schmieder, P, Schrader, T, Takeyoshi, M, van der Burg, B

“…Legislation and prospective legislative proposals in for instance the USA, Europe, and Japan require, or may require that chemicals are tested for their…”
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Neural stem cells from human cord blood on bioengineered surfaces—Novel approach to multiparameter bio-tests by Buzanska, L, Zychowicz, M, Ruiz, A, Ceriotti, L, Coecke, S, Rauscher, H, Sobanski, T, Whelan, M, Domanska-Janik, K, Colpo, P, Rossi, F

“…Abstract Stem cell technology combined with emerging surface nano/micro-technologies provides a new tool for better understanding of the mechanisms involved in…”
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Neuronal in vitro models for the estimation of acute systemic toxicity by Forsby, A., Bal-Price, A.K., Camins, A., Coecke, S., Fabre, N., Gustafsson, H., Honegger, P., Kinsner-Ovaskainen, A., Pallas, M., Rimbau, V., Rodríguez-Farré, E., Suñol, C., Vericat, J.A., Zurich, M.G.

“…The objective of the EU funded integrated project “ACuteTox” is to develop a strategy in which general cytotoxicity, together with organ-specific endpoints and…”
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Special issue: Evidence-based toxicology (EBT). Preface by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors by Schroeder, K., Bremm, K.D., Alépée, N., Bessems, J.G.M., Blaauboer, B., Boehn, S.N., Burek, C., Coecke, S., Gombau, L., Hewitt, N.J., Heylings, J., Huwyler, J., Jaeger, M., Jagelavicius, M., Jarrett, N., Ketelslegers, H., Kocina, I., Koester, J., Kreysa, J., Note, R., Poth, A., Radtke, M., Rogiers, V., Scheel, J., Schulz, T., Steinkellner, H., Toeroek, M., Whelan, M., Winkler, P., Diembeck, W.

“…There are now numerous in vitro and in silico ADME alternatives to in vivo assays but how do different industries incorporate them into their decision tree…”
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Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets by Scott, D.J, Devonshire, A.S, Adeleye, Y.A, Schutte, M.E, Rodrigues, M.R, Wilkes, T.M, Sacco, M.G, Gribaldo, L, Fabbri, M, Coecke, S, Whelan, M, Skinner, N, Bennett, A, White, A, Foy, C.A

“…Highlights ► Inter- and intra-laboratory reproducibility study of in vitro toxicogenomics. ► Case study using genotoxic carcinogen Benzo[a]pyrene (B[a]P)…”
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[P1.40]: Developmental neurotoxicants affect neuronal and glial differentiation and maturation in primary culture of rat cerebellum by Bal‐Price, A.K., Kinsner‐Ovaskainen, A., Coecke, S., Hartung, T., Hogberg, H.

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Stem-cell culture on patterned bio-functional surfaces by Ruiz, A., Buzanska, L., Ceriotti, L., Bretagnol, F., Coecke, S., Colpo, P., Rossi, F.

“…Bio-functional surfaces have been created by printing proteins on antifouling surfaces in a customised geometry. Human umbilical cord neural stem cells…”
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5 Steps toward an evidence-based toxicology: 5.1 evidence-based tools in toxicological basic research by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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Controlled micropatterning of biomolecules for cell culturing by Ruiz, A., Ceriotti, L., Buzanska, L., Hasiwa, M., Bretagnol, F., Ceccone, G., Gilliland, D., Rauscher, H., Coecke, S., Colpo, P., Rossi, F.

“…Various biomolecules have been patterned on anti-fouling substrates (Polyethylene glycol, PEG, plasma polymerized) by microcontact printing. Photolithography…”
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5.4 Possible improvement of information sources on hazard and risk by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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5.3 Evidence-based tools in toxicological decision-making by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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4.8 Current schemes for decision-making in toxicology by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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4.9 Current information sources for hazard identification by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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5.2 Evidence-based tools in toxicological hazard identification by Griesinger, C, Hoffmann, S, Kinsner, A, Coecke, S, Hartung, T

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5.6 An online portal to evidence-based toxicology by Kinsner, A, Griesinger, C, Hoffmann, S, Coecke, S, Bowe, G, Campana, C, Hartung, T

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