Search Results - "Coe, Paul L"

The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogs by Dyson, Michael R, Coe, Paul L, Walker, Richard T

“…Starting from benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro- pentofuranoside (4), the following 2'-deoxy nucleoside analogues have been synthesized:…”
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Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides by Rahim, S. George, Trivedi, Naimisha, Bogunovic-Batchelor, Mirjana V, Hardy, George W, Mills, Gail, Selway, John W. T, Snowden, Wendy, Littler, Edward, Coe, Paul L, Basnak, Ivan, Whale, Robert F, Walker, Richard T

“…A series of 5-substituted 2‘-deoxy-4‘-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as…”
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Synthesis and antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides by Bamford, Mark J, Coe, Paul L, Walker, Richard T

“…A series of 3'-branched-chain sugar nucleosides, in particular 3'-deoxy-3'-C-hydroxmethyl nucleosides, have been synthesized and evaluated as antiviral agents…”
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Synthesis and antiviral activity of some 3'-C-difluoromethyl- and 3'-deoxy-3'-C-fluoromethyl nucleosides by Bamford, Mark J, Coe, Paul L, Walker, Richard T

“…The synthesis and antiviral activity of a number of 3'-C-difluoromethyl and 3'-deoxy-3'-C-fluoromethyl nucleosides are reported. The 3'-C-difluoromethyl…”
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Conformation of two 4'-thio-2'-deoxynucleoside analogs studied by 5000-MHz proton NMR spectroscopy and x-ray crystallography by Koole, Leo H, Plavec, Janez, Liu, Hongying, Vincent, Beverly R, Dyson, Michael R, Coe, Paul L, Walker, Richard T, Hardy, George W, Rahim, S. George, Chattopadhyaya, Jyoti

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Preparation and reactions of 2,3,4,6-tetrafluoropyridine and its derivatives by Coe, Paul L, Rees, Anthony J

“…A reliable route to 2,3,4,6-tetrafluoropyridine has been established starting from the readily available 3,5-dichlorotrifluoropyridine by halogen exchange…”
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A simple stereoselective synthesis of biologically important 2-halo-2,3-dideoxy-arabinose derivatives from 1,1,1,2-tetrafluoroethane (134a) and 1-chloro-2,2,2-trifluoroethane (133a) by Coe, Paul L., Burdon, James, Haslock, Iain B.

“…A simple stereoselective three step synthesis of 2-fluoro- and 2-chloro-2,3-dideoxy arabinose derivatives from the readily available starting materials, (…”
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Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes by Verri, A, Focher, F, Duncombe, R J, Basnak, I, Walker, R T, Coe, P L, de Clercq, E, Andrei, G, Snoeck, R, Balzarini, J, Spadari, S

“…The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to…”
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4′-Methyloxycarbamyl-3′-deoxy-5-methyluridine; synthesis of a novel nucleoside analogue by Pickering, Lea, Malhi, Baljinder S, Coe, Paul L, Walker, Richard T

“…The preparation of 4′-methyloxycarbamyl-3′-deoxythymidine from chiral amino acid precursors is described. The route chosen employs a hitherto unreported…”
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Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines by Coe, Paul L, Harnden, Michael R, Jones, A. Stanley, Noble, Stewart A, Walker, Richard T

“…The following 5-substituted 2,4-dimethoxypyrimidines were synthesized: 5-(2,2,2-trichloro-1-hydroxyethyl),…”
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Polyfluorovinyl lithium reagents and their use in synthesis by Coe, Paul L.

“…The use of polyfluorovinyl lithium reagents in synthesis since their original discovery almost simultaneously by Seyferth and Tarrant and their development by…”
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Fluorinated analogs of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea: an attempt to control metabolism by Foster, Allan B, Jarman, Michael, Coe, Paul L, Sleigh, John, Tatlow, J. Colin

“…In seeking to block and thereby determine the role of the rapid in vivo hydroxylation of the cyclohexyl moiety of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea…”
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Fluorination of (+)-chiro-inositol with SF4/HF to give 2α,3β-difluoro-7-oxabicyclo[2.2.1]heptane-5α,6α-sulfite by Coe, Paul L., Maunder, Peter, Frampton, Christopher S., Martin, Joseph A., Anthony Thomas, W., Whitcombe, Ian W.A.

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Reactions of polyfluoropyridines with bidentate nucleophiles: attempts to prepare deazapurine analogues by Coe, Paul L., Rees, Anthony J., Whittaker, Jane

“…Reactions of pentafluoropyridine with guanidine, thiourea and urea with the hope of preparing derivatives which may be cyclised to polyfluorodeazapurines are…”
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Tetrafluorethene oligomers part 14 1reactions of perfluoro-3-methylpent-2-ene (tetrafluoroethylene trimer) with nucleophiles by Coe, Paul L., Ray, Nicholas C.

“…Perfluoro-3-methylpent-2-ene (tetrafluoroethylene (TFE) trimer) (1), produced by the flash vacuum thermolysis (FVT) of perfluoro-2,3-epoxy-4-ethyl-2,…”
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Fluorination of (+)- chiro-inositol with SF 4/HF to give 2α,3β-difluoro-7-oxabicyclo[2.2.1]heptane-5α,6α-sulfite by Coe, Paul L., Maunder, Peter, Frampton, Christopher S., Martin, Joseph A., Anthony Thomas, W., Whitcombe, Ian W.A.

“…Graphic The fluorination of (+)- chiro-inositol with SF 4/HF under moderate conditions affords a single product studied by 1 H and 19 F and 13 C NMR…”
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Anti-(herpes simplex virus) activity of 4′-thio-2′-deoxyuridines: a biochemical investigation for viral and cellular target enzymes by VERRI, Annalisa, FOCHER, Federico, DUNCOMBE, Richard J., BASNAK, Ivan, WALKER, Richard T., COE, Paul L., DE CLERCQ, Erik, ANDREI, Graciela, SNOECK, Robert, BALZARINI, Jan, SPADARI, Silvio

“…The antiviral activity of several nucleoside analogues is often limited by their rapid degradation by pyrimidine nucleoside phosphorylases. In an attempt to…”
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Electrophilic ipso substitution of trimethylsilyl groups in fluorobenzenes by Coe, Paul L., Stuart, Alison M., Moody, David J.

“…Using variants of literature methods 2,4- and 2,6- difluorophenyltrimethylsilanes have been bromodesilylated to the corresponding bromodifluorobenzenes in…”
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Fluorodesilylations of fluorophenyltrimethylsilanes with elemental fluorine: discovery of a novel 1,2-migration of the trimethylsilyl group by Stuart, Alison M., Coe, Paul L., Moody, David J.

“…The main product in the direct elemental fluorination of 4-fluorophenyltrimethylsilane was 1,4-difluorobenzene, produced by the ipso electrophilic substitution…”
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Chloropolyfluoro-derivatives of ethyl methyl ether by Coe, Paul L., Rowbotham, Roger A., Tatlow, John Colin

“…Fluorination of 2-chloroethyl methyl ether by potassium tetrafluorocobaltate at 180–250 °C gave various tri-, tetra-, penta- and hexafluoro(2-chloroethyl…”
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