Search Results - "Codogno, Patrice"

Machinery, regulation and pathophysiological implications of autophagosome maturation by Zhao, Yan G., Codogno, Patrice, Zhang, Hong

“…Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome…”
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Autophagy in stem cells: repair, remodelling and metabolic reprogramming by Boya, Patricia, Codogno, Patrice, Rodriguez-Muela, Natalia

“…Autophagy is a catabolic pathway by which cellular components are delivered to the lysosome for degradation and recycling. Autophagy serves as a crucial…”
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Emerging regulation and functions of autophagy by Boya, Patricia, Reggiori, Fulvio, Codogno, Patrice

“…Autophagy maintains cell, tissue and organism homeostasis through degradation. Codogno, Boya and Reggiori review recent data that have uncovered unexpected…”
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Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics by Nascimbeni, Anna Chiara, Codogno, Patrice, Morel, Etienne

“…Phosphatidylinositol‐3‐phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. Most PI3P is associated with endosomal membranes and…”
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Autophagy modulation as a potential therapeutic target for diverse diseases by Rubinsztein, David C., Codogno, Patrice, Levine, Beth

“…Key Points Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and…”
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Canonical and non-canonical autophagy: variations on a common theme of self-eating? by Codogno, Patrice, Mehrpour, Maryam, Proikas-Cezanne, Tassula

“…The autophagosome, the central organelle in macroautophagy, is constructed from a membrane template called the phagophore, to which autophagy-related (ATG)…”
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Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production by Scrivo, Aurora, Codogno, Patrice, Bomont, Pascale

“…Autophagy is an essential self-digestion machinery for cell survival and homoeostasis. Membrane elongation is fundamental, as it drives the formation of the…”
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Overview of macroautophagy regulation in mammalian cells by Mehrpour, Maryam, Esclatine, Audrey, Beau, Isabelle, Codogno, Patrice

“…Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue…”
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p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth by Nowosad, Ada, Jeannot, Pauline, Callot, Caroline, Creff, Justine, Perchey, Renaud Thierry, Joffre, Carine, Codogno, Patrice, Manenti, Stephane, Besson, Arnaud

“…Autophagy is a catabolic process whereby cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis during nutrient…”
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Autophagic cell death: Loch Ness monster or endangered species? by Shen, Han-Ming, Codogno, Patrice

“…The concept of autophagic cell death was first established based on observations of increased autophagic markers in dying cells. The major limitation of such a…”
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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion by Zhou, Jing, Tan, Shi-Hao, Nicolas, Valérie, Bauvy, Chantal, Yang, Nai-Di, Zhang, Jianbin, Xue, Yuan, Codogno, Patrice, Shen, Han-Ming

“…Lysosome is a key subceilular organelle in the execution of the autophagic process and at present little is known whether lysosomal function is controlled in…”
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PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress by Boukhalfa, Asma, Nascimbeni, Anna Chiara, Ramel, Damien, Dupont, Nicolas, Hirsch, Emilio, Gayral, Stephanie, Laffargue, Muriel, Codogno, Patrice, Morel, Etienne

“…Cells subjected to stress situations mobilize specific membranes and proteins to initiate autophagy. Phosphatidylinositol-3-phosphate (PI3P), a crucial lipid…”
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The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells by Miceli, Caterina, Roccio, Federica, Penalva-Mousset, Lucille, Burtin, Martine, Leroy, Christine, Nemazanyy, Ivan, Kuperwasser, Nicolas, Pontoglio, Marco, Friedlander, Gérard, Morel, Etienne, Terzi, Fabiola, Codogno, Patrice, Dupont, Nicolas

“…Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly…”
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Salinomycin kills cancer stem cells by sequestering iron in lysosomes by Mai, Trang Thi, Hamaï, Ahmed, Hienzsch, Antje, Cañeque, Tatiana, Müller, Sebastian, Wicinski, Julien, Cabaud, Olivier, Leroy, Christine, David, Amandine, Acevedo, Verónica, Ryo, Akihide, Ginestier, Christophe, Birnbaum, Daniel, Charafe-Jauffret, Emmanuelle, Codogno, Patrice, Mehrpour, Maryam, Rodriguez, Raphaël

“…Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically…”
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Autophagy: A Druggable Process by Morel, Etienne, Mehrpour, Maryam, Botti, Joëlle, Dupont, Nicolas, Hamaï, Ahmed, Nascimbeni, Anna Chiara, Codogno, Patrice

“…Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for catabolism of intracellular material that is conserved among eukaryotic cells…”
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Regulation of autophagy by amino acids and MTOR-dependent signal transduction by Meijer, Alfred J, Lorin, Séverine, Blommaart, Edward F, Codogno, Patrice

“…Amino acids not only participate in intermediary metabolism but also stimulate insulin-mechanistic target of rapamycin (MTOR)-mediated signal transduction…”
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Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression by Liang, Gehao, Ling, Yun, Mehrpour, Maryam, Saw, Phei Er, Liu, Zihao, Tan, Weige, Tian, Zhenluan, Zhong, Wenjing, Lin, Wanyi, Luo, Qing, Lin, Qun, Li, Qiufang, Zhou, You, Hamai, Ahmed, Codogno, Patrice, Li, Jun, Song, Erwei, Gong, Chang

“…Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via…”
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Autophagy and microtubules - new story, old players by Mackeh, Rafah, Perdiz, Daniel, Lorin, Séverine, Codogno, Patrice, Poüs, Christian

“…Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle…”
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Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview by Mehrpour, Maryam, Esclatine, Audrey, Beau, Isabelle, Codogno, Patrice

“…Macroautophagy is a vacuolar degradation pathway that terminates in the lysosomal compartment after formation of a cytoplasmic vacuole or autophagosome that…”
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The Mechanism and Physiological Function of Macroautophagy by Klionsky, Daniel J., Codogno, Patrice

“…With regard to cell biology, one area of focus that has shifted back and forth over the years has been the relative emphasis on catabolic versus anabolic…”
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