Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach

Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required informatio...

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Bibliographic Details
Published in:	Frontiers in physiology Vol. 12; p. 733009
Main Authors:	Guvenir Torun, Su, Torun, Hakki M., Hansen, Hendrik H. G., Gandini, Giulia, Berselli, Irene, Codazzi, Veronica, de Korte, Chris L., van der Steen, Antonius F. W., Migliavacca, Francesco, Chiastra, Claudio, Akyildiz, Ali C.
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 07-09-2021
Subjects:	atherosclerosis Bayesian optimization coronary artery finite element analysis inflation test material constant Physiology
Online Access:	Get full text
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Summary:	Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of atherosclerotic coronaries remains to be scarce. In this work, we characterized the component-wise mechanical properties of atherosclerotic human coronary arteries. To achieve this, we performed ex vivo inflation tests on post-mortem human coronary arteries and developed an inverse FE modeling (iFEM) pipeline, which combined high-frequency ultrasound deformation measurements, a high-field magnetic resonance-based artery composition characterization, and a machine learning-based Bayesian optimization (BO) with uniqueness assessment. By using the developed pipeline, 10 cross-sections from five atherosclerotic human coronary arteries were analyzed, and the Yeoh material model constants of the fibrous intima and arterial wall components were determined. This work outlines the developed pipeline and provides the knowledge of non-linear, multicomponent mechanical properties of atherosclerotic human coronary arteries.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Dalin Tang, Worcester Polytechnic Institute, United States This article was submitted to Computational Physiology and Medicine, a section of the journal Frontiers in Physiology Reviewed by: Qingyu Wang, Nanjing Medical University, China; Kristen L. Billiar, Worcester Polytechnic Institute, United States
ISSN:	1664-042X 1664-042X
DOI:	10.3389/fphys.2021.733009