Search Results - "Cocuzza, A J"

Use of the suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists by Cocuzza, Anthony J., Chidester, Dennis R., Culp, Steven, Fitzgerald, Lawrence, Gilligan, Paul

“…The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH 1 receptor. Examples with several different…”
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A System for Rapid DNA Sequencing with Fluorescent Chain-Terminating Dideoxynucleotides by Prober, James M., Trainor, George L., Dam, Rudy J., Hobbs, Frank W., Robertson, Charles W., Zagursky, Robert J., Cocuzza, Anthony J., Jensen, Mark A., Baumeister, Kirk

“…A DNA sequencing system based on the use of a novel set of four chain-terminating dideoxynucleotides, each carrying a different chemically tuned…”
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4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists by Cocuzza, Anthony J., Hobbs, Frank W., Arnold, Charles R., Chidester, Dennis R., Yarem, Jerry A., Culp, Steven, Fitzgerald, Lawrence, Gilligan, Paul J.

“…A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each…”
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Synthesis and Evaluation of Efavirenz (Sustiva TM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain by Cocuzza, Anthony J., Chidester, Dennis R., Cordova, Beverly C., Jeffrey, Susan, Parsons, Rodney L., Bacheler, Lee T., Erickson-Viitanen, Susan, Trainor, George L., Ko, Soo S.

“…Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the…”
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Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate by Sands, H, Gorey-Feret, L J, Cocuzza, A J, Hobbs, F W, Chidester, D, Trainor, G L

“…Biodistribution and metabolism of oligonucleotides were determined using a 3H-labeled 20-nucleotide phosphodiester and its phosphorothioate analog. The…”
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Synthetic studies toward mitomycins. 2. Total synthesis of dl-porfiromycin by Nakatsubo, F, Fukuyama, T, Cocuzza, A. J, Kishi, Y

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Synthetic studies toward mitomycins. 1. Total synthesis of deiminomitomycin A by Nakatsubo, F, Cocuzza, A. J, Keeley, D. E, Kishi, Y

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Conjugation of a monoclonal antibody with a DTPA modified random copolymer of hydroxyethyl methylacrylate and methyl methacrylate by Comeau, R D, Liberatore, F A, Cocuzza, A J, Emond, G Y, Dicker, I B

“…A new approach for covalent coupling diethylenetriaminepentaacetic acid (DTPA) molecules to a partially reduced monoclonal antibody utilizes a malemide…”
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4,1-Benzoxazepinone analogues of efavirenz (Sustiva™) as HIV-1 reverse transcriptase inhibitors by Cocuzza, Anthony J., Chidester, Dennis R., Cordova, Beverly C., Klabe, Ronald M., Jeffrey, Susan, Diamond, Sharon, Weigelt, Carolyn A., Ko, Soo S., Bacheler, Lee T., Erickson-Viitanen, Susan K., Rodgers, James D.

“…A series of 4,1-benzoxazepinone analogues of efavirenz (Sustiva™) as potent NNRTIs has been discovered. The cis-3-alkylbenzoxazepinones are more potent then…”
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Biodistribution and metabolism of internally 3H-labeled oligonucleotides. II. 3',5'-blocked oligonucleotides by Sands, H, Gorey-Feret, L J, Ho, S P, Bao, Y, Cocuzza, A J, Chidester, D, Hobbs, F W

“…The pharmacokinetics and metabolism of four radiolabeled phosphodiester oligonucleotides with 3'- and 5'-blocked ends were studied in mice and compared with…”
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Non-Peptide Corticotropin-Releasing Hormone Antagonists:  Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines by Arvanitis, Argyrios G, Gilligan, Paul J, Chorvat, Robert J, Cheeseman, Robert S, Christos, Thomas E, Bakthavatchalam, Rajagopal, Beck, James P, Cocuzza, Anthony J, Hobbs, Frank W, Wilde, Richard G, Arnold, Charles, Chidester, Dennis, Curry, Matthew, He, Liqi, Hollis, Andrea, Klaczkiewicz, John, Krenitsky, Paul J, Rescinito, Joseph P, Scholfield, Everett, Culp, Steven, De Souza, Errol B, Fitzgerald, Lawrence, Grigoriadis, Dimitri, Tam, S. William, Wong, Y. Nancy, Huang, Shiew-Mei, Shen, Helen L

“…Screening of our chemical library using a rat corticotropin-releasing hormone (CRH) receptor assay led to the discovery that 2-anilinopyrimidine 15 - 1 weakly…”
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Synthesis, Corticotropin-Releasing Factor Receptor Binding Affinity, and Pharmacokinetic Properties of Triazolo-, Imidazo-, and Pyrrolopyrimidines and -pyridines by Chorvat, Robert J, Bakthavatchalam, Rajagopal, Beck, James P, Gilligan, Paul J, Wilde, Richard G, Cocuzza, Anthony J, Hobbs, Frank W, Cheeseman, Robert S, Curry, Matthew, Rescinito, Joseph P, Krenitsky, Paul, Chidester, Dennis, Yarem, Jerry A, Klaczkiewicz, John D, Hodge, C. Nicholas, Aldrich, Paul E, Wasserman, Zelda R, Fernandez, Christine H, Zaczek, Robert, Fitzgerald, Lawrence W, Huang, Shiew-Mei, Shen, Helen L, Wong, Y. Nancy, Chien, Ben M, Quon, Check Y, Arvanitis, Argyrios

“…The synthesis and CRF receptor binding affinities of several new series of N-aryltriazolo- and -imidazopyrimidines and -pyridines are described. These cyclized…”
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Improvements in the chain-termination method of DNA sequencing through the use of 7-deaza-2'-deoxyadenosine by Jensen, M A, Zagursky, R J, Trainor, G L, Cocuzza, A J, Lee, A, Chen, E Y

“…Significant improvements in the quality of DNA sequencing data have been shown when deoxyadenosine triphosphate (dATP) is replaced by 7-deaza-2'-deoxyadenosine…”
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Synthesis and properties of 7-azaxanthopterin by Taylor, Edward C, Cocuzza, Anthony J

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Pteridines. 41. Synthesis and dihydrofolate reductase inhibitory activity of some cycloalka[g]pteridines by Taylor, Edward C, Berrier, John V, Cocuzza, Anthony J, Kobylecki, Ryszard, McCormack, John J

“…A number of homologous 2,4-diaminocycloalka[g]pteridines varying in ring size from 5 to 15 were prepared by (a) condensation of aminomalononitrile tosylate…”
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