Search Results - "Coco, John"

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH by Allen, Eric L., Ulanet, Danielle B., Pirman, David, Mahoney, Christopher E., Coco, John, Si, Yaguang, Chen, Ying, Huang, Lingling, Ren, Jinmin, Choe, Sung, Clasquin, Michelle F., Artin, Erin, Fan, Zi Peng, Cianchetta, Giovanni, Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Smolen, Gromoslaw A.

“…Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained…”
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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase by McDonald, Gabrielle, Chubukov, Victor, Coco, John, Truskowski, Kevin, Narayanaswamy, Rohini, Choe, Sung, Steadman, Mya, Artin, Erin, Padyana, Anil K, Jin, Lei, Ronseaux, Sebastien, Locuson, Charles, Fan, Zi-Peng, Erdmann, Tabea, Mann, Alan, Hayes, Sebastian, Fletcher, Mark, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Reddy, K Satish, Panigrahi, Sunil K, Antony, Thomas, Gopinath, Sreevalsam, Sui, Zhihua, Nagaraja, Nelamangala, Dang, Lenny, Lenz, Georg, Hurov, Jonathan, Biller, Scott A, Murtie, Josh, Marks, Kevin M, Ulanet, Danielle B

“…Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies…”
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Hematologic Malignancies Exhibit Selective Vulnerability to Inhibition of De Novo Pyrimidine Biosynthesis By AG-636, a Novel Inhibitor of Dihydroorotate Dehydrogenase in Phase 1 Clinical Trials by Ulanet, Danielle, Chubukov, Victor, Coco, John, McDonald, Gabrielle, Steadman, Mya, Narayanaswamy, Rohini, Ronseaux, Sebastien, Choe, Sung, Erdmann, Tabea, Truskowski, Kevin, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Lenz, Georg, Cooper, Michael, Murtie, Josh, Marks, Kevin

“…Rapidly proliferating cells reprogram metabolism to support increased biosynthetic demands, a feature that can expose targetable vulnerabilities for…”
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Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo by Tillotson, Bonnie, Slocum, Kelly, Coco, John, Whitebread, Nigel, Thomas, Brian, West, Kip A., MacDougall, John, Ge, Jie, Ali, Janid A., Palombella, Vito J., Normant, Emmanuel, Adams, Julian, Fritz, Christian C.

“…Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration…”
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Abstract B145: The novel Hedgehog pathway inhibitor IPI-926 delays metastatic spread and provides a survival benefit in an experimental model of pancreatic liver metastasis by Coco, John, West, Kip, McGovern, Karen, Read, Margaret, MacDougall, John, Fritz, Christian

“…Abstract Metastasis, or the spread of disseminated tumor cells to and colonization of distal sites, is a major cause of cancer mortality. The Hedgehog (Hh)…”
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Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119 by Brophy, Erin, Conley, James, O'Hearn, Patrick, Douglas, Mark, Cheung, Culver, Coco, John, D'Anello, Laura, Wylie, Andrew, Tibbitts, Thomas, Keaney, Gregg, Chan, Lawrence, Bahadoor, Adilah, Snyder, Dan, Nevalainen, Marta, Castro, Alfredo, Palombella, Vito, Loda, Massimo, Peluso, Stephane

“…Abstract Fatty acid synthase (FASN) is a key enzyme responsible for fatty acids synthesis de novo in mammals. Overexpression of FASN is common in many cancers…”
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Computer Simulation of the Polymerization of Styrene. The Mechanism of Thermal Initiation and the Importance of Primary Radical Termination by Pryor, William A, Coco, John H

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1546/The Ortho Birth Control Satisfaction Assessment Tool (Ortho BC-SAT): Reliability and Validity of a New Satisfaction Questionnaire by Susan Mathias, John Lo Coco, Debra Karvois, Hilary Colwell, Tricia Cimms, Andrew J. Friedman

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THE MECHANISM OF THE THERMAL POLYMERIZATION OF STYRENE by COCO, JOHN HENRY

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1534/Measuring Satisfaction with Hormonal Contraceptives: A Conceptual Framework for a Generic Measure of Satisfaction by Mathias, Susan D., Hilary H. Colwell, Tricia Cimms, Debra L. Karvois, John M. Lo Coco, Andrew J. Friedman

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