Search Results - "Cockrell, Gael"

Enhanced Excretion of Vitamin D Binding Protein in Type 1 Diabetes: A Role in Vitamin D Deficiency? by Thrailkill, Kathryn M, Jo, Chan-Hee, Cockrell, Gael E, Moreau, Cynthia S, Fowlkes, John L

“…Context: Vitamin D deficiency is an increasingly recognized comorbidity in patients with both type 1 (T1D) and type 2 diabetes, particularly associated with…”
Get full text

SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice by Thrailkill, Kathryn M, Clay Bunn, R, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

“…Abstract Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone,…”
Get full text

Palmitate and insulin synergistically induce IL-6 expression in human monocytes by Bunn, Robert C, Cockrell, Gael E, Ou, Yang, Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Fowlkes, John L

“…Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and…”
Get full text

Microalbuminuria in Type 1 Diabetes Is Associated With Enhanced Excretion of the Endocytic Multiligand Receptors Megalin and Cubilin by Thrailkill, Kathryn M, Nimmo, Teresa, Bunn, R. Clay, Cockrell, Gael E, Moreau, Cynthia S, Mackintosh, Samuel, Edmondson, Ricky D, Fowlkes, John L

“…OBJECTIVE: Proteinuria is the hallmark of diabetic nephropathy; yet, glomerular histology does not fully explain mechanisms contributing to proteinuria. Our…”
Get full text

Increasing duration of type 1 diabetes perturbs the strength–structure relationship and increases brittleness of bone by Nyman, Jeffry S, Even, Jesse L, Jo, Chan-Hee, Herbert, Erik G, Murry, Matthew R, Cockrell, Gael E, Wahl, Elizabeth C, Bunn, R. Clay, Lumpkin, Charles K, Fowlkes, John L, Thrailkill, Kathryn M

“…Abstract Type 1 diabetes (T1DM) increases the likelihood of a fracture. Despite serious complications in the healing of fractures among those with diabetes,…”
Get full text

Matrix Metalloproteinase-2 Dysregulation in Type 1 Diabetes by Thrailkill, Kathryn M, Bunn, Robert C, Moreau, Cynthia S, Cockrell, Gael E, Simpson, Pippa M, Coleman, Hannah N, Frindik, J. Paul, Kemp, Stephen F, Fowlkes, John L

“…OBJECTIVE:--Dysregulation of matrix metalloproteinase (MMP)-2 may contribute pathologically to the development of diabetes complications, including diabetic…”
Get full text

Runt-Related Transcription Factor 2 (RUNX2) and RUNX2-Related Osteogenic Genes Are Down-Regulated throughout Osteogenesis in Type 1 Diabetes Mellitus by Fowlkes, John L, Bunn, R. Clay, Liu, Lichu, Wahl, Elizabeth C, Coleman, Hannah N, Cockrell, Gael E, Perrien, Daniel S, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Type 1 diabetes mellitus is associated with a number of disorders of skeletal health, conditions that rely, in part, on dynamic bone formation. A mouse model…”
Get full text

Corrigendum to “SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice” [Bone 82 (2016) 101–107] by Thrailkill, Kathryn M, Bunn, R.C, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

Get full text

Bone Formation Is Impaired in a Model of Type 1 Diabetes by THRAILKILL, Kathryn M, LICHU LIU, ARONSON, James, LUMPKIN, Charles K, WAHL, Elizabeth C, BUNN, Robert C, PERRIEN, Daniel S, COCKRELL, Gael E, SKINNER, Robert A, HOGUE, William R, CARVER, Adam A, FOWLKES, John L

“…Bone Formation Is Impaired in a Model of Type 1 Diabetes Kathryn M. Thrailkill 1 , Lichu Liu 2 , Elizabeth C. Wahl 2 , Robert C. Bunn 1 , Daniel S. Perrien 3 4…”
Get full text

Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone by Nyman, Jeffry S., Fowlkes, John L., Morris, Lindsey, Cockrell, Gael E., Wahl, Elizabeth C., Lumpkin, Charles K., Bunn, R. Clay, Thrailkill, Kathryn M., Kahn, C. Ronald

“…Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility…”
Get full text

Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes by Fowlkes, John L, Nyman, Jeffry S, Bunn, R. Clay, Jo, Chanhee, Wahl, Elizabeth C, Liu, Lichu, Cockrell, Gael E, Morris, Lindsey M, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Abstract Objective Using a streptozotocin (STZ)-induced mouse model of type 1 diabetes (T1D), we have previously demonstrated that long-term diabetes inhibits…”
Get full text

Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus by Thrailkill, Kathryn M., Moreau, Cynthia S., Cockrell, Gael E., Jo, Chan-Hee, Bunn, Robert C., Morales-Pozzo, Alba E., Lumpkin, Charles K., Fowlkes, John L.

“…Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal injury, can bind matrix metalloproteinase-9 (MMP-9) and inhibit its degradation,…”
Get full text

Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Clark, Lindsey M, Ou, Yang, Isales, Carlos M, Badger, Thomas M, Ronis, Martin J, Sims, John, Lumpkin, Charles K

“…Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised…”
Get full text

Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model by Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K

“…DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local…”
Get full text

Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Ronis, Martin J.J, Lumpkin, Charles K

“…Abstract Distraction osteogenesis (DO) is a process which induces direct new bone formation as a result of mechanical distraction. Tumor necrosis factor-α…”
Get full text

Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice by Fowlkes, John L, Nyman, Jeffry S, Bunn, R Clay, Cockrell, Gael E, Wahl, Elizabeth C, Rettiganti, Mallikarjuna R, Lumpkin, Jr, Charles K, Thrailkill, Kathryn M

“…In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of…”
Get full text

A novel rat model for the study of deficits in bone formation in type-2 diabetes by Liu, Zhendong, Aronson, James, Wahl, Elizabeth C, Liu, Lichu, Perrien, Daniel S, Kern, Phillip A, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Cockrell, Gael E, Skinner, Robert A, Lumpkin, Jr, Charles K

“…There is evidence to suggest that impairment in bone formation and/or turnover is associated with the metabolic abnormalities characteristic of type-2 diabetes…”
Get more information

Mutational analysis of the IgE-binding epitopes of P34/Gly m Bd 30K by Helm, Ricki M., Cockrell, Gael, Connaughton, Cathie, West, C.Michael, Herman, Eliot, Sampson, Hugh A., Bannon, Gary A., Burks, A.Wesley

“…Background: Peanuts and soybeans are 2 foods that have been shown to be responsible for many atopic disorders. Because of their nutritional benefit, soybean…”
Get full text

Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity by Burks, A.W, Shin, D, Cockrell, G, Stanley, J.S, Helm, R.M, Bannon, G.A

“…Peanut allergy is a significant health problem because of the prevelance and potential severity of the allergic reaction. Serum IgE from patients with…”
Get full text

Cellular and molecular characterization of a major soybean allergen by Helm, R, Cockrell, G, Herman, E, Burks, A, Sampson, H, Bannon, G

“…Soybean proteins share a large number of cross-reacting allergens with other members of the legume family; however, soy-allergic patients rarely react…”
Get more information