Search Results - "Cockcroft, Shamshad"

Phospholipase C families: Common themes and versatility in physiology and pathology by Katan, Matilda, Cockcroft, Shamshad

“…Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all mammalian cells and play critical roles in signal transduction. To obtain a…”
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Phospholipid transport protein function at organelle contact sites by Cockcroft, Shamshad, Raghu, Padinjat

“…Phospholipids are synthesized at the endoplasmic reticulum (ER), the largest membrane bound organelle that forms membrane contact sites (MCS) with almost every…”
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Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases by Cockcroft, Shamshad

“…Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second…”
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A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport by Gatta, Alberto T, Wong, Louise H, Sere, Yves Y, Calderón-Noreña, Diana M, Cockcroft, Shamshad, Menon, Anant K, Levine, Tim P

“…Sterol traffic between the endoplasmic reticulum (ER) and plasma membrane (PM) is a fundamental cellular process that occurs by a poorly understood…”
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CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis by Blunsom, Nicholas J, Cockcroft, Shamshad

“…Cytidine diphosphate diacylglycerol (CDP-DAG) is a key intermediate in the synthesis of phosphatidylinositol (PI) and cardiolipin (CL). Both PI and CL have…”
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Courier service for phosphatidylinositol: PITPs deliver on demand by Ashlin, Tim G., Blunsom, Nicholas J., Cockcroft, Shamshad

“…Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes…”
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Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation by Leishman, Stuart, Aljadeed, Najd M., Qian, Liyunhe, Cockcroft, Shamshad, Behmoaras, Jacques, Anand, Paras K.

“…Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in…”
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Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1) Binds and Transfers Phosphatidic Acid by Garner, Kathryn, Hunt, Alan N., Koster, Grielof, Somerharju, Pentti, Groves, Emily, Li, Michelle, Raghu, Padinjat, Holic, Roman, Cockcroft, Shamshad

“…Phosphatidylinositol transfer proteins (PITPs) are versatile proteins required for signal transduction and membrane traffic. The best characterized mammalian…”
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Mammalian PITPs at the Golgi and ER-Golgi Membrane Contact Sites by Cockcroft, Shamshad, Lev, Sima

“…Phosphatidylinositol (PI)-transfer proteins (PITPs) have been long recognized as proteins that modulate phosphoinositide levels in membranes through their…”
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Biochemical and biological functions of class I phosphatidylinositol transfer proteins by Cockcroft, Shamshad, Carvou, Nicolas

“…Phosphoinositides function in a diverse array of cellular activities. They include a role as substrate for lipid kinases and phospholipases to generate second…”
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Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action? by Cockcroft, Shamshad, Garner, Kathryn

“…Phosphatidylinositol transfer proteins (PITPs) bind and facilitate the transport of phosphatidylinositol (PI) and phosphatidylcholine between membrane…”
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Pitpnc1a Regulates Zebrafish Sleep and Wake Behavior through Modulation of Insulin-like Growth Factor Signaling by Ashlin, Tim G., Blunsom, Nicholas J., Ghosh, Marcus, Cockcroft, Shamshad, Rihel, Jason

“…The lipid transporters of the phosphatidylinositol transfer protein (PITP) family dictate phosphoinositide compartmentalization, and specific phosphoinositides…”
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Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis by Zhao, Liang, Thorsheim, Chelsea L., Suzuki, Aae, Stalker, Timothy J., Min, Sang H., Lian, Lurong, Fairn, Gregory D., Cockcroft, Shamshad, Durham, Amy, Krishnaswamy, Sriram, Abrams, Charles S.

“…Platelets are increasingly recognized for their contributions to tumor metastasis. Here, we show that the phosphoinositide signaling modulated by…”
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Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases by Hyvola, Noora, Diao, Aipo, McKenzie, Eddie, Skippen, Alison, Cockcroft, Shamshad, Lowe, Martin

“…The X‐linked disorder oculocerebrorenal syndrome of Lowe is caused by mutation of the OCRL1 protein, an inositol polyphosphate 5‐phosphatase. OCRL1 is…”
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Identification of a Plasmodium falciparum Phospholipid Transfer Protein by van Ooij, Christiaan, Withers-Martinez, Chrislaine, Ringel, Alessa, Cockcroft, Shamshad, Haldar, Kasturi, Blackman, Michael J.

“…Infection of erythrocytes by the human malaria parasite Plasmodium falciparum results in dramatic modifications to the host cell, including changes to its…”
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The expanding roles of PI4P and PI(4,5)P2 at the plasma membrane: Role of phosphatidylinositol transfer proteins by Cockcroft, Shamshad

“…Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid that is synthesised at the endoplasmic reticulum. The plasma membrane…”
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Expanding functions of the phosphatidylinositol/phosphatidate lipid transporter, PITPNC1 in physiology and in pathology by Cockcroft, Shamshad

“…PITPNC1 was the last of the PITPs to be identified and has been characterized as a binding protein for phosphatidylinositol and phosphatidate. In mammals,…”
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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane by Katan, Matilda, Cockcroft, Shamshad

“…Phosphatidylinositol(4,5) bisphosphate (PI(4,5)P2) has become a major focus in biochemistry, cell biology and physiology owing to its diverse functions at the…”
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Current thoughts on the phosphatidylinositol transfer protein family by Allen-Baume, Victoria, Ségui, Bruno, Cockcroft, Shamshad

“…Monomeric transport of lipids is carried out by a class of proteins that can shield a lipid from the aqueous environment by binding the lipid in a hydrophobic…”
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Phosphatidylinositol transfer proteins couple lipid transport to phosphoinositide synthesis by Cockcroft, Shamshad

“…Phosphatidylinositol transfer proteins (PITPs) are lipid binding proteins that can catalyse the transfer of phosphatidylinositol (PI) from membranes enriched…”
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