Search Results - "Cockburn, B. N."

Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene by GRAGNOLI, C, LINDNER, T, COCKBURN, B. N, KAISAKI, P. J, GRAGNOLI, F, MAROZZI, G, BELL, G. I

“…Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1…”
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Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1α and glucokinase by GRAGNOLI, C, COCKBURN, B. N, CHIARAMONTE, F, GORINI, A, MARIETTI, G, MAROZZI, G, SIGNORINI, A. M

“…Maturity-onset-diabetes of the young (MODY) is caused by mutations in at least five different genes. Our aim was to determine the prevalence of the most common…”
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Association of the KCNJ11 variant E23K with type 2 diabetes in Indo-Trinidadians by Boodram, L G, Miyake, K, Hayes, M G, Bell, G I, Cockburn, B N

“…To examine the effect of genetic variation in KCNJ11 on the risk of Type 2 diabetes mellitus in Trinidadians. The coding and bordering intron-exon regions of…”
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Monitoring of International Diabetes Federation-recommended Clinical Diabetes Indicators in a Public Health Centre in Southwest Trinidad by Dhanoo, A S, Cockburn, B N, Shah, N, Superville, R, Hill-Briggs, F

“…To examine availability of International Diabetes Federation (IDF)-recommended diabetes indicators in the medical charts of patients in active care at a public…”
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Molecular genetics of MODY in Germany by Lindner, T H, Cockburn, B N, Bell, G I

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Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: Role of enhanced fuel metabolism by Zhou, Yun-Ping, Cockburn, Brian N., Pugh, William, Polonsky, Kenneth S.

“…The biochemical mechanisms responsible for basal hyperinsulinemia in insulin-resistant states have not been fully defined. We therefore studied pancreatic…”
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Hyperexcitability to sulphonylurea in MODY3 by Søvik, O, Njølstad, P, Følling, I, Sagen, J, Cockburn, B N, Bell, G I

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Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice by SREENAN, S. K, COCKBURN, B. N, BALDWIN, A. C, OSTREGA, D. M, LEVISETTI, M, GRUPE, A, BELL, G. I, STEWART, T. A, ROE, M. W, POLONSKY, K. S

“…Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice. S K Sreenan , B N Cockburn , A C Baldwin , D M Ostrega , M Levisetti , A…”
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes by Cockburn, B. N., Ostrega, D. M., Sturis, J., Kubstrup, C., Polonsky, K. S., Bell, G. I.

“…Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. B N Cockburn , D M Ostrega , J…”
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Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY by Horikawa, Yukio, Iwasaki, Naoko, Hara, Manami, Furuta, Hiroto, Hinokio, Yoshinori, Cockburn, Brian N, Lindner, Tom, Yamagata, Kazuya, Ogata, Makiko, Tomonaga, Osamu, Kuroki, Hiroyuki, Kasahara, Tadasu, Iwamoto, Yasuhiko, Bell, Graeme I

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Prevalence of the metabolic syndrome in patients with diabetes mellitus by AlSaraj, F., McDermott, J. H., Cawood, T., McAteer, S., Ali, M., Tormey, W., Cockburn, B. N., Sreenan, S.

“…Background Metabolic syndrome (MetS) is a vascular risk factor with prevalence in the general population of 17–25%. Aim To determine the prevalence of MetS in…”
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A missense mutation, Val62Ala, in the glucokinase gene in a Norwegian family with maturity-onset diabetes of the young by Njølstad, PR, Cockburn, BN, Bell, GI, Søvik, O

“…Maturity‐onset diabetes of the young (MODY) is a form of diabetes mellitus characterized by autosomal dominant inheritance, onset usually before 25 y of age…”
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Gene symbol: IPF1. Disease: MODY 4 by Cockburn, B N, Bermano, G, Boodram, L L, Teelucksingh, S, Tsuchiya, T, Mahabir, D, Allan, A B, Stein, R, Docherty, K, Bell, G I

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Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1α genes in patients with early-onset Type 2 diabetes mellitus/MODY by Ng, M. C. Y., Cockburn, B. N., Lindner, T. H., Yeung, V. T. F., Chow, C. -C., So, W. -Y., Li, J. K. Y., Lo, Y. M. D., Lee, Z. S. K., Cockram, C. S., Critchley, J. A. J. H., Bell, G. I., Chan, J. C. N.

“…Summary Aims To examine the prevalence of identified MODY‐related genes in Chinese subjects with early onset Type 2 diabetes mellitus and a positive family…”
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes by COCKBURN, B. N, OSTREGA, D. M, STURIS, J, KUBSTRUP, C, POLONSKY, K. S, BELL, G. I

“…We examined changes in high- and low-Km glucose phosphorylating activity in pancreatic islet extracts from the prediabetic Zucker diabetic fatty (ZDF) rat…”
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Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme by Deyrup, A T, Krishnan, S, Cockburn, B N, Schwartz, N B

“…The P-loop is a common motif found in ATP- and GTP-binding proteins. The recently cloned murine ATP-sulfurylase/adenosine 5'-phosphosulfate (APS) kinase…”
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A case of hepatocyte nuclear factor-1 alpha diabetes/MODY3 masquerading as type 1 diabetes in a Mexican-American adolescent and responsive to a low dose of sulfonylurea by Hathout, E H, Cockburn, B N, Mace, J W, Sharkey, J, Chen-Daniel, J, Bell, G I

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Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney by Cockburn, B N, Coore, H G

“…Pyruvate dehydrogenase complex (PDC) from rat kidney or pig heart previously inactivated by phosphorylation (PDHP) was activated in vitro by PDHP phosphatase…”
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Phospholamban ‐ SERCA2a Interactions In Hearts From Streptozotocin‐Induced Diabetic Rats by Singh, Shamjeet, Barnes, J A, Bidasee, K R, Ramdath, D D, Bourne, G A, Cockburn, B N

“…Reduced cardiac contractility is a primary cause for morbidity in diabetic patients. One protein that contributes to this defect is the sarco(endo)plasmic…”
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Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1[alpha] and glucokinase by Gragnoli, C, Cockburn, B N, Chiaramonte, F, Gorini, A, Marietti, G, Marozzi, G, Signorini, A M

“…Maturity-onset-diabetes of the young (MODY) is caused by mutations in at least five different genes. Our aim was to determine the prevalence of the most common…”
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