Search Results - "Cochrane, Charles G."

Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys by REVAK, S. D, MERRITT, T. A, COCHRANE, C. G, HELDT, G. P, ALBERTS, M. S, ANDERSON, D. W, KHEITER, A

“…Studies were conducted to assess the efficacy and safety of a synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome (RDS)…”
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Pulmonary surfactant in allergic inflammation: new insights into the molecular mechanisms of surfactant function by Cochrane, Charles G

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A Multicenter, Randomized, Controlled Trial Comparing Surfaxin (Lucinactant) Lavage With Standard Care for Treatment of Meconium Aspiration Syndrome by Wiswell, Thomas E, Knight, Gail R, Finer, Neil N, Donn, Steven M, Desai, Hemant, Walsh, William F, Sekar, Krishnamurthy C, Bernstein, Graham, Keszler, Martin, Visser, Valya E, Merritt, T. Allen, Mannino, Frank L, Mastrioianni, Lisa, Marcy, Brian, Revak, Susan D, Tsai, Huei, Cochrane, Charles G

“…Infants with meconium aspiration syndrome (MAS) have marked surfactant dysfunction. Airways and alveoli of affected neonates contain meconium, inflammatory…”
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Bronchopulmonary segmental lavage with Surfaxin (KL4-surfactant) for acute respiratory distress syndrome by WISWELL, T. E, SMITH, R. M, REVAK, S. D, COCHRANE, C. G, KATZ, L. B, MASTROIANNI, L, WONG, D. Y, WILLMS, D, HEARD, S, WILSON, M, HITE, R. D, ANZUETO, A

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Bronchoalveolar lavage with KL4-surfactant in models of meconium aspiration syndrome by COCHRANE, C. G, REVAK, S. D, MERRITT, T. A, SCHRAUFSTÄTTER, I. U, HOCH, R. C, HENDERSON, C, ANDERSSON, S, TAKAMORI, H, OADES, Z. G

“…As a model of the meconium aspiration syndrome (MAS) of human infants, adult rabbits and newborn rhesus monkeys received intratracheal instillation of human…”
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fMet-Leu-Phe Stimulates Proinflammatory Cytokine Gene Expression in Human Peripheral Blood Monocytes: The Role of Phosphatidylinositol 3-Kinase by Pan, Zhixing K, Chen, Ling-Yu, Cochrane, Charles G, Zuraw, Bruce L

“…The fMLP-stimulated release of proinflammatory cytokines such as IL-1 by human peripheral blood monocytes is an important component of the inflammatory…”
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Surfactant lavage treatment in a model of respiratory distress syndrome by Cochrane, C G, Revak, S D

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Depletion of Plasma Complement in Vivo by a Protein of Cobra Venom: Its Effect on Various Immunologic Reactions by Cochrane, Charles G, Muller-Eberhard, Hans J, Aikin, Barbara S

“…Abstract The purified low molecular weight anticomplementary factor (CoF) in the venom of the cobra Naja naja was tested for its behavior in vivo and for its…”
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The Role of Tyr and Lys of Interleukin-8 in the High Affinity Interaction with the Interleukin-8 Receptor Type A by Ingrid U. Schraufstätter, Min Ma, Zenaida G. Oades, Diana S. Barritt, Charles G. Cochrane

“…Interleukin-8 (IL-8) has at least two binding regions for both the A and the B type IL-8 receptors. This study defines an important region between Cys 7 and…”
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Positive end-expiratory pressure during KL4 surfactant instillation enhances intrapulmonary distribution in a Simian model of respiratory distress syndrome by MERRITT, T. A, AHMED KHEITER, COCHRANE, C. G

“…Intrapulmonary distribution of a peptide-phospholipid (KL4) surfactant administered through an adapter permitting maintenance of positive end-expiratory…”
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The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants by Revak, S D, Merritt, T A, Hallman, M, Heldt, G, La Polla, R J, Hoey, K, Houghten, R A, Cochrane, C G

“…Synthetic pulmonary surfactants consisting of mixtures of phospholipids with synthetic peptides based on the amino acid sequence of human surfactant apoprotein…”
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Identification of anN-Formyl Peptide Receptor Ligand Binding Domain by a Gain-of-Function Approach by Quehenberger, Oswald, Pan, Zhixing K., Prossnitz, Eric R., Cavanagh, Stacey L., Cochrane, Charles G., Ye, Richard D.

“…Replacement of N-formyl peptide receptor (FPR) domains with those from a homologous receptor, FPR2, resulted in chimeric receptors displaying low binding…”
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Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B by Vincent, James S, Revak, Susan D, Cochrane, Charles G, Levin, Ira W

“…The temperature dependence of dipalmitoylphosphatidylcholine (DPPC)/phosphatidylglycerol (PG) multilayers, reconstituted with various synthetic peptides for…”
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Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells by Hyslop, P A, Hinshaw, D B, Schraufstätter, I U, Sklar, L A, Spragg, R G, Cochrane, C G

“…The effects of exposure of cultured P388D1 cells to H2O2 on intracellular free calcium ([Ca++]i) was investigated utilizing the intracellular fluorescent…”
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The biochemistry and pathophysiology of the contact system of plasma by Cochrane, C G, Griffin, J H

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Site of Deposition of C3 in Arthus Reactions of C4 Deficient Guinea Pigs by Frank, Michael M, Ellman, L, Green, I, Cochrane, Charles G

“…Summary The site of C3 deposition in the direct Arthus reaction induced in a strain of guinea pigs with a nonoperative classical complement pathway but a…”
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Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein by Schreiber, R E, Prossnitz, E R, Ye, R D, Cochrane, C G, Jesaitis, A J, Bokoch, G M

“…A recombinant human neutrophil N-formyl peptide receptor (rFPR) expressed in transfected mouse fibroblasts (TX2 cells) was analyzed for its ability to couple…”
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Direct evidence for Hageman factor (factor XII) activation by bacterial lipopolysaccharides (endotoxins) by Morrison, D C, Cochrane, C G

“…Purified precursor Hageman factor has been demonstrated to bind to soluble bacterial lipopolysaccharide (LPS, endotoxin) isolated from Escherichia coli…”
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Cellular injury by oxidants by Cochrane, C G

“…Oxidants, generated by stimulated leukocytes, induce a variety of distinct biochemical changes in target cells. Hypochlorous acid (HOCl), produced by the…”
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Mechanisms involved in the deposition of immune complexes in tissues by Cochrane, C G

“…The mechanisms reponsible for the deposition of circulating immune complexes have been analyzed. An active process appears to be responsible in both a…”
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