Search Results - "Cochran, Andrea G"

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications by Flynn, E. Megan, Huang, Oscar W., Poy, Florence, Oppikofer, Mariano, Bellon, Steve F., Tang, Yong, Cochran, Andrea G.

“…Bromodomains are epigenetic readers that are recruited to acetyllysine residues in histone tails. Recent studies have identified non-acetyl acyllysine…”
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BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase by Taherbhoy, Asad M., Huang, Oscar W., Cochran, Andrea G.

“…Polycomb repressive complex 1 (PRC1) is required for ubiquitination of histone H2A lysine 119, an epigenetic mark associated with repression of genes important…”
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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells by Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie

“…KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates…”
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Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6 by Bourhis, Eric, Wang, Weiru, Tam, Christine, Hwang, Jiyoung, Zhang, Yingnan, Spittler, Didier, Huang, Oscar W., Gong, Yan, Estevez, Alberto, Zilberleyb, Inna, Rouge, Lionel, Chiu, Cecilia, Wu, Yan, Costa, Mike, Hannoush, Rami N., Franke, Yvonne, Cochran, Andrea G.

“…The Wnt pathway inhibitors DKK1 and sclerostin (SOST) are important therapeutic targets in diseases involving bone loss or damage. It has been appreciated that…”
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Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6 by Bourhis, Eric, Tam, Christine, Franke, Yvonne, Bazan, J. Fernando, Ernst, James, Hwang, Jiyoung, Costa, Mike, Cochran, Andrea G., Hannoush, Rami N.

“…Wnt/β-catenin signaling is initiated at the cell surface by association of secreted Wnt with its receptors Frizzled (Fz) and low density lipoprotein…”
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Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex by Bentley, Matthew L, Corn, Jacob E, Dong, Ken C, Phung, Qui, Cheung, Tommy K, Cochran, Andrea G

“…The Polycomb repressive complex 1 (PRC1) mediates gene silencing, in part by monoubiquitination of histone H2A on lysine 119 (uH2A). Bmi1 and Ring1b are…”
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Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300 by Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven

“…The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target of much recent interest in cancer and immune system regulation…”
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage by Oppikofer, Mariano, Sagolla, Meredith, Haley, Benjamin, Zhang, Hui-Min, Kummerfeld, Sarah K., Sudhamsu, Jawahar, Flynn, E. Megan, Bai, Tianyi, Zhang, Jennifer, Ciferri, Claudio, Cochran, Andrea G.

“…Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA…”
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Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance by Crawford, Terry D., Vartanian, Steffan, Côté, Alexandre, Bellon, Steve, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Zawadzke, Laura, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G., Stokoe, David

“…[Display omitted] Bromodomain-containing protein 9 (BRD9), an epigenetic “reader” of acetylated lysines on post-translationally modified histone proteins, is…”
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Tryptophan Zippers: Stable, Monomeric β-Hairpins by Cochran, Andrea G., Skelton, Nicholas J., Starovasnik, Melissa A.

“…A structural motif, the tryptophan zipper (trpzip), greatly stabilizes the β-hairpin conformation in short peptides. Peptides (12 or 16 aa in length) with four…”
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Bromodomains: a new target class for drug development by Cochran, Andrea G., Conery, Andrew R., Sims, Robert J.

“…Less than a decade ago, it was shown that bromodomains, acetyl lysine ‘reader’ modules found in proteins with varied functions, were highly tractable…”
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GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1 by Cochran, Andrea G., Flynn, Megan

“…Bromodomains are acetyl-lysine binding modules that are found in different classes of chromatin-interacting proteins. Among these are large chromatin…”
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The Mitotic Regulator Survivin Binds as a Monomer to Its Functional Interactor Borealin by Bourhis, Eric, Hymowitz, Sarah G., Cochran, Andrea G.

“…Survivin is a member of the IAP (inhibitor of apoptosis) protein family, defined in part by the presence of a zinc-binding baculoviral inhibitory repeat (BIR)…”
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Short Constrained Peptides That Inhibit HIV-1 Entry by Sia, Samuel K., Carr, Peter A., Cochran, Andrea G., Malashkevich, Vladimir N., Kim, Peter S.

“…Peptides corresponding to the C-terminal heptad repeat of HIV-1 gp41 (C-peptides) are potent inhibitors of HIV-1 entry into cells. Their mechanism of…”
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Expansion of the ISWI chromatin remodeler family with new active complexes by Oppikofer, Mariano, Bai, Tianyi, Gan, Yutian, Haley, Benjamin, Liu, Peter, Sandoval, Wendy, Ciferri, Claudio, Cochran, Andrea G

“…ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two…”
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Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 by Bourhis, Eric, Tam, Christine, Franke, Yvonne, Bazan, J Fernando, Ernst, James, Hwang, Jiyoung, Costa, Mike, Cochran, Andrea G, Hannoush, Rami N

“…Wnt/beta-catenin signaling is initiated at the cell surface by association of secreted Wnt with its receptors Frizzled (Fz) and low density lipoprotein…”
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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells by Rutz, Sascha, Kayagaki, Nobuhiko, Phung, Qui T., Eidenschenk, Celine, Noubade, Rajkumar, Wang, Xiaoting, Lesch, Justin, Lu, Rongze, Newton, Kim, Huang, Oscar W., Cochran, Andrea G., Vasser, Mark, Fauber, Benjamin P., DeVoss, Jason, Webster, Joshua, Diehl, Lauri, Modrusan, Zora, Kirkpatrick, Donald S., Lill, Jennie R., Ouyang, Wenjun, Dixit, Vishva M.

“…The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in T H 17 cells; DUBA interacts with and stabilizes the…”
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Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation by Miller, Gregory M., Flynn, E. Megan, Tom, Jeffrey, Song, Aimin, Cochran, Andrea G.

“…Genetic code expansion has proven invaluable to the elucidation of functions of defined protein modifications through the site-specific incorporation of…”
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Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains by Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G

“…The biological role played by non-BET bromodomains remains poorly understood, and it is therefore imperative to identify potent and highly selective inhibitors…”
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1 by Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.

“…Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with…”
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