Search Results - "Cochlin, Lowri"

Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold by Piechnik, Stefan K, Ferreira, Vanessa M, Dall'Armellina, Erica, Cochlin, Lowri E, Greiser, Andreas, Neubauer, Stefan, Robson, Matthew D

“…T1 mapping allows direct in-vivo quantitation of microscopic changes in the myocardium, providing new diagnostic insights into cardiac disease. Existing…”
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Novel ketone diet enhances physical and cognitive performance by Murray, Andrew J., Knight, Nicholas S., Cole, Mark A., Cochlin, Lowri E., Carter, Emma, Tchabanenko, Kirill, Pichulik, Tica, Gulston, Melanie K., Atherton, Helen J., Schroeder, Marie A., Deacon, Robert M. J., Kashiwaya, Yoshihiro, King, M. Todd, Pawlosky, Robert, Rawlins, J. Nicholas P., Tyler, Damian J., Griffin, Julian L., Robertson, Jeremy, Veech, Richard L., Clarke, Kieran

“…ABSTRACT Ketone bodies are the most energy‐efficient fuel and yield more ATP permole of substrate than pyruvate and increase the free energy released from ATP…”
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In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance by Schroeder, Marie A, Cochlin, Lowri E, Heather, Lisa C, Clarke, Kieran, Radda, George K, Tyler, Damian J

“…The advent of hyperpolarized ¹³C magnetic resonance (MR) has provided new potential for the real-time visualization of in vivo metabolic processes. The aim of…”
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Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy by DASS, Sairia, SUTTIE, Joseph J, WATKINS, Hugh, NEUBAUER, Stefan, PIECHNIK, Stefan K, FERREIRA, Vanessa M, HOLLOWAY, Cameron J, BANERJEE, Rajarshi, MAHMOD, Masliza, COCHLIN, Lowri, KARAMITSOS, Theodoros D, ROBSON, Matthew D

“…Noncontrast magnetic resonance T1 mapping reflects a composite of both intra- and extracellular signal. We hypothesized that noncontrast T1 mapping can…”
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A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart by Cole, Mark A., Murray, Andrew J., Cochlin, Lowri E., Heather, Lisa C., McAleese, Sara, Knight, Nicholas S., Sutton, Elizabeth, Jamil, Amira Abd, Parassol, Nadege, Clarke, Kieran

“…Elevated levels of cardiac mitochondrial uncoupling protein 3 (UCP3) and decreased cardiac efficiency (hydraulic power/oxygen consumption) with abnormal…”
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A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects by Holloway, Cameron J, Cochlin, Lowri E, Emmanuel, Yaso, Murray, Andrew, Codreanu, Ion, Edwards, Lindsay M, Szmigielski, Cezary, Tyler, Damian J, Knight, Nicholas S, Saxby, Brian K, Lambert, Bridget, Thompson, Campbell, Neubauer, Stefan, Clarke, Kieran

“…Background: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free…”
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Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction by Dass, Sairia, Cochlin, Lowri E, Suttie, Joseph J, Holloway, Cameron J, Rider, Oliver J, Carden, Leah, Tyler, Damian J, Karamitsos, Theodoros D, Clarke, Kieran, Neubauer, Stefan, Watkins, Hugh

“…Hypertrophic cardiomyopathy (HCM) is the commonest cause of sudden cardiac death in the young, with an excess of exercise-related deaths. The HCM sarcomere…”
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Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding by Murray, Andrew J, Knight, Nicholas S, Cochlin, Lowri E, McAleese, Sara, Deacon, Robert M.J, Rawlins, J. Nicholas P, Clarke, Kieran

“…Efficiency, defined as the amount of work produced for a given amount of oxygen consumed, is a key determinant of endurance capacity, and can be altered by…”
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No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure by Dass, Sairia, Holloway, Cameron J, Cochlin, Lowri E, Rider, Oliver J, Mahmod, Masliza, Robson, Matthew, Sever, Emily, Clarke, Kieran, Watkins, Hugh, Ashrafian, Houman, Karamitsos, Theodoros D, Neubauer, Stefan

“…Whether the myocardium in nonischemic heart failure experiences oxygen limitation remains a long-standing controversy. We addressed this question in patients…”
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Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate by Clarke, Kieran, Tchabanenko, Kirill, Pawlosky, Robert, Carter, Emma, Knight, Nicholas S., Murray, Andrew J., Cochlin, Lowri E., King, M. Todd, Wong, Andrea W., Roberts, Ashley, Robertson, Jeremy, Veech, Richard L.

“…► (R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone ester) is an oral source of ketones. ► Rats consumed diets containing ketone ester for 28days. ► Consumption…”
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Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp by Holloway, Cameron J, Montgomery, Hugh E, Murray, Andrew J, Cochlin, Lowri E, Codreanu, Ion, Hopwood, Naomi, Johnson, Andrew W, Rider, Oliver J, Levett, Denny Z.H, Tyler, Damian J, Francis, Jane M, Neubauer, Stefan, Grocott, Michael P.W, Clarke, Kieran

“…We postulated that changes in cardiac high-energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers…”
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Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac high energy phosphate metabolism by Holloway, Cameron J, Dass, Sairia, Suttie, Joseph J, Rider, Oliver J, Cox, Pete, Cochlin, Lowri E, Jackson, Hamish, Fast, Angela M, Johnson, Andrew W, Karamitsos, Theodoros D, Neubauer, Stefan, Clarke, Kieran

“…To determine the effects of short-term exercise training on cardiac function and metabolism during rest and physical exercise in patients with heart failure…”
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The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism by Schroeder, Marie A., Atherton, Helen J., Cochlin, Lowri E., Clarke, Kieran, Radda, George K., Tyler, Damian J.

“…Hyperpolarized 13C‐labeled substrates directly provide a source of magnetic resonance (MR) signal to observe the substrates' real‐time uptake and enzymatic…”
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Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats by Murray, Andrew J, Knight, Nicholas S, Little, Sarah E, Cochlin, Lowri E, Clements, Mary, Clarke, Kieran

“…Short-term consumption of a high-fat diet impairs exercise capacity in both rats and humans, and increases expression of the mitochondrial uncoupling protein,…”
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Cardiac energy metabolism and oxygenation during exercise in the hypertensive heart by Dass, Sairia, Ariga, Rina, Sever, Emily, Cochlin, Lowri E, Suttie, Joseph, Holloway, Cameron, Mahmod, Masliza, Karamitsos, Theodoros D, Neubauer, Stefan

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Cardiac 31 P MRS analysis development: Improved fitting of 2, 3 DPG by Dass, Sairia, Tyler, Damian, Neubauer, Stefan, Clarke, Kieran, Cochlin, Lowri E

“…Doc number: P219…”
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Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance by Emmanuel, Yaso, Cochlin, Lowri E., Tyler, Damian J., Jager, Celeste A., David Smith, A., Clarke, Kieran

“…Neuronal glucose uptake was thought to be independent of insulin, being facilitated by glucose transporters GLUT1 and GLUT3, which do not require insulin…”
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Derangement of cardiac energy metabolism is acutely exacerbated during exercise in hypertrophic cardiomyopathy, independent of hypertrophy or late gadolinium burden by Dass, Sairia, Cochlin, Lowri E, Suttie, Joseph, Holloway, Cameron, Rodgers, Christopher T, Tyler, Damian, Karamitsos, Theodoros, Clarke, Kieran, Watkins, Hugh, Neubauer, Stefan

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Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP by Holloway, Cameron J, Murray, Andrew J, Mitchell, Kay, Martin, Daniel S, Johnson, Andrew W, Cochlin, Lowri E, Codreanu, Ion, Dhillon, Sundeep, Rodway, George W, Ashmore, Tom, Levett, Denny Z H, Neubauer, Stefan, Montgomery, Hugh E, Grocott, Michael P W, Clarke, Kieran

“…Exposure to high altitude is associated with sustained, but reversible, changes in cardiac mass, diastolic function, and high-energy phosphate metabolism…”
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Normobaric hypoxia elevates free fatty acids and impairs cardiac energetics and diastolic function in normal human volunteers by Holloway, Cameron J, Cochlin, Lowri E, Codreanu, Ion, Bloch, Edward, Fatemianl, Marzieh, Szmigielski, Cezary, Johnson, Andrew, Francis, Jane M, Robbins, Peter, Neubauer, Stefan, Clarke, Kieran

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