Search Results - "Coburn‐Flynn, Olivia"

Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter by Petersen, Ines, Gabryszewski, Stanislaw J., Johnston, Geoffrey L., Dhingra, Satish K., Ecker, Andrea, Lewis, Rebecca E., Almeida, Mariana Justino, Straimer, Judith, Henrich, Philipp P., Palatulan, Eugene, Johnson, David J., Coburn‐Flynn, Olivia, Sanchez, Cecilia, Lehane, Adele M., Lanzer, Michael, Fidock, David A.

“…Summary The widespread use of chloroquine to treat Plasmodium falciparum infections has resulted in the selection and dissemination of variant haplotypes of…”
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum by Gulati, Sonia, Ekland, Eric H., Ruggles, Kelly V., Chan, Robin B., Jayabalasingham, Bamini, Zhou, Bowen, Mantel, Pierre-Yves, Lee, Marcus C.S., Spottiswoode, Natasha, Coburn-Flynn, Olivia, Hjelmqvist, Daisy, Worgall, Tilla S., Marti, Matthias, Di Paolo, Gilbert, Fidock, David A.

“…During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids. Consistent…”
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A broad analysis of resistance development in the malaria parasite by Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.

“…Microbial resistance to chemotherapy has caused countless deaths where malaria is endemic. Chemotherapy may fail either due to pre-existing resistance or…”
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505 NOVEL EPIGENETIC THERAPY FOR HYPERTHERMAL INTRAPERITONEAL CHEMOTHERAPY ENABLES GENE REMODELING OF THE TUMOR MICROENVIRONMENT by Coburn-Flynn, Olivia K., Butchy, Margaret V., Calendo, Gennaro, Emery, Robert, Verchio, Vincent, Knapp, Kristen, Ladd, Zachary, Zhang, Ping, Spitz, Francis, Jelinek, Jaroslav, Hong, Young K.

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Exploring cell competition for the prevention and therapy of esophageal squamous cell carcinoma by Knapp, Kristen, Verchio, Vincent, Coburn-Flynn, Olivia, Li, Yahui, Xiong, Zhaohui, Morrison, Jamin C., Shersher, David D., Spitz, Francis, Chen, Xiaoxin

“…[Display omitted] Esophageal squamous cell carcinoma (ESCC) is characterized by the development of cancer in the esophageal squamous epithelium through a…”
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Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics by Cowell, Annie N, Istvan, Eva S, Lukens, Amanda K, Gomez-Lorenzo, Maria G, Vanaerschot, Manu, Sakata-Kato, Tomoyo, Flannery, Erika L, Magistrado, Pamela, Owen, Edward, Abraham, Matthew, LaMonte, Gregory, Painter, Heather J, Williams, Roy M, Franco, Virginia, Linares, Maria, Arriaga, Ignacio, Bopp, Selina, Corey, Victoria C, Gnädig, Nina F, Coburn-Flynn, Olivia, Reimer, Christin, Gupta, Purva, Murithi, James M, Moura, Pedro A, Fuchs, Olivia, Sasaki, Erika, Kim, Sang W, Teng, Christine H, Wang, Lawrence T, Akidil, Aslı, Adjalley, Sophie, Willis, Paul A, Siegel, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Llinás, Manuel, Ottilie, Sabine, Gamo, Francisco-Javier, Lee, Marcus C S, Goldberg, Daniel E, Fidock, David A, Wirth, Dyann F, Winzeler, Elizabeth A

“…Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes…”
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Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors by Schlott, Anja C, Mayclin, Stephen, Reers, Alexandra R, Coburn-Flynn, Olivia, Bell, Andrew S, Green, Judith, Knuepfer, Ellen, Charter, David, Bonnert, Roger, Campo, Brice, Burrows, Jeremy, Lyons-Abbott, Sally, Staker, Bart L, Chung, Chun-Wa, Myler, Peter J, Fidock, David A, Tate, Edward W, Holder, Anthony A

“…The attachment of myristate to the N-terminal glycine of certain proteins is largely a co-translational modification catalyzed by N-myristoyltransferase (NMT),…”
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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance by Murithi, James M, Deni, Ioanna, Pasaje, Charisse Flerida A, Okombo, John, Bridgford, Jessica L, Gnädig, Nina F, Edwards, Rachel L, Yeo, Tomas, Mok, Sachel, Burkhard, Anna Y, Coburn-Flynn, Olivia, Istvan, Eva S, Sakata-Kato, Tomoyo, Gomez-Lorenzo, Maria G, Cowell, Annie N, Wicht, Kathryn J, Le Manach, Claire, Kalantarov, Gavreel F, Dey, Sumanta, Duffey, Maëlle, Laleu, Benoît, Lukens, Amanda K, Ottilie, Sabine, Vanaerschot, Manu, Trakht, Ilya N, Gamo, Francisco-Javier, Wirth, Dyann F, Goldberg, Daniel E, Odom John, Audrey R, Chibale, Kelly, Winzeler, Elizabeth A, Niles, Jacquin C, Fidock, David A

“…Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital need to develop compounds with novel modes of action and identify…”
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A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost by Monárrez, Rubén, Braun, Molly, Coburn-Flynn, Olivia, Botelho, João, Odetoyin, Babatunde W., Otero-Vera, Jose I., Quartey, Naa Kwarley Eyiram, Peixe, Luísa, Aboderin, Aaron O., Okeke, Iruka N.

“…Antimicrobial resistance is rapidly expanding, in a large part due to mobile genetic elements. We screened 94 fecal fluoroquinolone-resistant Escherichia coli…”
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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate by Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.

“…The widespread emergence of Plasmodium falciparum ( Pf ) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel…”
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Structural insights on three series of anti-malarial N -myristoyltransferase inhibitors by Mayclin, Stephen, Schlott, Anja, Reers, Alexandra, Coburn-Flynn, Olivia, Holder, Anthony, Bell, Andrew, Fidock, David, Tate, Edward

“…Abstract only…”
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N‑Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds by Ramachandran, Sreekanth, Hameed P, Shahul, Srivastava, Abhishek, Shanbhag, Gajanan, Morayya, Sapna, Rautela, Nikhil, Awasthy, Disha, Kavanagh, Stefan, Bharath, Sowmya, Reddy, Jitendar, Panduga, Vijender, Prabhakar, K. R, Saralaya, Ramanatha, Nanduri, Robert, Raichurkar, Anandkumar, Menasinakai, Sreenivasaiah, Achar, Vijayashree, Jiménez-Díaz, María Belén, Martínez, María Santos, Angulo-Barturen, Iñigo, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Duffy, Sandra, Avery, Vicky M, Waterson, David, Lee, Marcus C. S, Coburn-Flynn, Olivia, Fidock, David A, Iyer, Pravin S, Narayanan, Shridhar, Hosagrahara, Vinayak, Sambandamurthy, Vasan K

“…From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual…”
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Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites by Frame, I. J, Deniskin, Roman, Rinderspacher, Alison, Katz, Francine, Deng, Shi-Xian, Moir, Robyn D, Adjalley, Sophie H, Coburn-Flynn, Olivia, Fidock, David A, Willis, Ian M, Landry, Donald W, Akabas, Myles H

“…Equilibrative transporters are potential drug targets; however, most functional assays involve radioactive substrate uptake that is unsuitable for…”
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Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter by Petersen, Ines, Gabryszewski, Stanislaw J., Johnston, Geoffrey L., Dhingra, Satish K., Ecker, Andrea, Lewis, Rebecca E., de Almeida, Mariana Justino, Straimer, Judith, Henrich, Philipp P., Palatulan, Eugene, Johnson, David J., Coburn‐Flynn, Olivia, Sanchez, Cecilia, Lehane, Adele M., Lanzer, Michael, Fidock, David A.

“…The widespread use of chloroquine to treat P lasmodium falciparum infections has resulted in the selection and dissemination of variant haplotypes of the…”
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