Search Results - "Cobley, Christopher"

Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin by Carlone, Armando, Bernardi, Luca, McCormack, Peter, Warr, Tony, Oruganti, Srinivas, Cobley, Christopher J

“…Herein, we present the scale up development of an innovative synthetic process to pregabalin. The process is underpinned by two enabling technologies critical…”
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An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes by Noonan, Gary M., Fuentes, José A., Cobley, Christopher J., Clarke, Matthew L.

“…Surprising selectivity: The first enantioselective hydroformylations of simple alkenes of type RCH2CHCH2 to preferentially deliver the branched aldehyde…”
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Simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and methoxycarbonylation of vinyl arenes by Konrad, Tina M, Durrani, Jamie T, Cobley, Christopher J, Clarke, Matthew L

“…Using a family of novel mononuclear and dinuclear palladium complexes of phanephos ligands, the simultaneous control of regioselectivity and enantioselectivity…”
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New catalytic route for the synthesis of an optically active tetralone-derived amine for rotigotine by Cobley, Christopher J., Evans, George, Fanjul, Tamara, Simmonds, Shaun, Woods, Amy

“…[Display omitted] Rotigotine is a launched drug for the treatment of Parkinson’s disease and restless legs syndrome. The key steps of an alternative route for…”
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Polycationic Rh–JosiPhos Polymers Supported on Phosphotungstic Acid/Al2O3 by Multiple Electrostatic Attractions by Nepal, Prabin, Kalapugama, Suneth, Shevlin, Michael, Naber, John R, Campeau, Louis-Charles, Pezzetta, Cristofer, Carlone, Armando, Cobley, Christopher J, Bergens, Steven H

“…Cationic Rh–JosiPhos complexes were tethered to crowded, ring-opening olefin metathesis (ROMP)-active norbornene groups. These monomers underwent facile,…”
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Synthesis of (R)‐3‐(tert‐Butoxycarbonylamino)‐4‐(2,4,5‐trifluorophenyl)butanoic Acid, a Key Intermediate, and the Formal Synthesis of Sitagliptin Phosphate by Sreenivasulu, Kurella, Chaudhari, Pramod S., Achanta, Srinivas, Sud, Abhishek, Dahanukar, Vilas, Cobley, Christopher J., Llewellyn‐Beard, Fiona, Bandichhor, Rakeshwar

“…An alternate formal synthesis of Sitagliptin phosphate is disclosed from 2,4,5‐trifluorobenzadehyde in 8 linear steps with an overall yield of 31%. The chiral…”
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Organocatalytic Asymmetric Conjugate Additions to Cyclopent-1-enecarbaldehyde: A Critical Assessment of Organocatalytic Approaches towards the Telaprevir Bicyclic Core by Bernardi, Luca, Fochi, Mariafrancesca, Carbone, Riccardo, Martinelli, Ada, Fox, Martin E., Cobley, Christopher J., Kandagatla, Bhaskar, Oruganti, Srinivas, Dahanukar, Vilas H., Carlone, Armando

“…In the context of a programme directed at the manufacture of telaprevir, eight possible approaches to its bicyclic α‐amino acid core, based on organocatalytic…”
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Enantioselective Hydrogenation of Imines Using a Diverse Library of Ruthenium Dichloride(diphosphine)(diamine) Precatalysts by Cobley, Christopher J., Henschke, Julian P.

“…A range of aromatic and cyclic imines were subjected to asymmetric hydrogenation with catalysts derived from complexes of the type RuCl2(diphosphine)(diamine)…”
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Regioselective and Enantioselective Hydroformylation of Dialkylacrylamides by Noonan, Gary M., Newton, David, Cobley, Christopher J., Suárez, Andrés, Pizzano, Antonio, Clarke, Matthew L.

“…Dimethylacrylamide can be hydroformylated with very high chemo‐ and regioselectivity. Asymmetric hydroformylation of this substrate is possible, provided steps…”
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Highly Regio- and Enantioselective Asymmetric Hydroformylation of Olefins Mediated by 2,5-Disubstituted Phospholane Ligands by Axtell, Alex T., Cobley, Christopher J., Klosin, Jerzy, Whiteker, Gregory T., Zanotti-Gerosa, Antonio, Abboud, Khalil A.

“…Off the shelf: The commercially available ligand (R,R)‐1,2‐bis(2,5‐diphenylphospholano)ethane ((R,R)‐Ph‐bpe) has been identified as an excellent ligand for…”
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Asymmetric Hydroformylation of an Enantiomerically Pure Bicyclic Lactam: Efficient Synthesis of Functionalised Cyclopentylamines by Noonan, Gary M., Cobley, Christopher J., Lebl, Tomas, Clarke, Matthew L.

“…Customising a bicycle: Rh‐catalysed asymmetric hydroformylation of a bicyclic lactam, 2‐azabicyclo‐[2.2.1]hept‐5‐en‐3‐one, was investigated. The use of a…”
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Bridging Group Effects in Chelating Bis(2,5-diphenylphospholane) Ligands for Rhodium-Catalyzed Asymmetric Hydroformylation by Axtell, Alex T, Klosin, Jerzy, Whiteker, Gregory T, Cobley, Christopher J, Fox, Martin E, Jackson, Mark, Abboud, Khalil A

“…A series of seven bis(2,5-diphenylphospholane) ligands has been evaluated for utility in rhodium-catalyzed asymmetric hydroformylation. The ligands differ in…”
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Effect of the Dihedral Angle of Biaryl-Bridged Bisphosphite Ligands on Enantioselectivity and Regioselectivity of Asymmetric Hydroformylation by Cobley, Christopher J, Froese, Robert D. J, Klosin, Jerzy, Qin, Cheng, Whiteker, Gregory T, Abboud, Khalil A

“…Eight new biaryl-bridged bisphosphite ligands have been synthesized and applied in rhodium-catalyzed asymmetric hydroformylation of styrene, allyl cyanide, and…”
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Parallel Ligand Screening on Olefin Mixtures in Asymmetric Hydroformylation Reactions by Cobley, Christopher J, Klosin, Jerzy, Qin, Cheng, Whiteker, Gregory T

“…Herein we describe a new protocol for catalyst evaluation in asymmetric hydroformylation reactions where multisubstrate screening is performed in an array of…”
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Synthesis and Application of a New Bisphosphite Ligand Collection for Asymmetric Hydroformylation of Allyl Cyanide by Cobley, Christopher J, Gardner, Kelli, Klosin, Jerzy, Praquin, Céline, Hill, Catherine, Whiteker, Gregory T, Zanotti-Gerosa, Antonio, Petersen, Jeffrey L, Abboud, Khalil A

“…A series of mono- and bidentate phosphites was prepared with (S)-5,5‘,6,6‘-tetramethyl-3,3‘-di-tert-butyl-1,1‘-biphenyl-2,2‘-dioxy [(S)-BIPHEN] as a chiral…”
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The Combination of Hydroformylation and Biocatalysis for the Large-Scale Synthesis of (S)-Allysine Ethylene Acetal by Cobley, Christopher J, Hanson, Christopher H, Lloyd, Michael C, Simmonds, Shaun, Peng, Wei Jun

“…The compound, (S)-2-amino-5-[1,3]dioxolan-2-yl-pentanoic acid [(S)-allysine ethylene acetal], is a key intermediate in a number of angiotension-I converting…”
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Synthesis and Applications of HexaPHEMP, a Novel Biaryl Diphosphine Ligand by Henschke, Julian P., Burk, Mark J., Malan, Christophe G., Herzberg, Daniela, Peterson, Justine A., Wildsmith, Andrew J., Cobley, Christopher J., Casy, Guy

“…The novel biaryldiphosphine ligand 1 (HexaPHEMP) has been prepared in five steps from commercially available 3,4,5‐trimethylphenol using a concise synthetic…”
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Microwave accelerated Suzuki coupling of chloro-aryl phosphine-oxides: A method for introducing diversity into phosphine ligands by Damian, Karen, Clarke, Matthew L., Cobley, Christopher J.

“…There is a demand for methodology that can rapidly produce families of catalysts for catalyst–structure–performance studies. The results reported here show…”
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Platinum catalysed hydrolytic amidation of unactivated nitriles by Cobley, Christopher J, van den Heuvel, Marco, Abbadi, Abdelilah, de Vries, Johannes G

“…The platinum(II) complex, [(Me 2PO··H··OPMe 2)PtH(PMe 2OH)], efficiently catalyses the direct conversion of unactivated nitriles to N-substituted amides with…”
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Highly Efficient Asymmetric Hydrogenation of 2-Methylenesuccinamic Acid Using a Rh-DuPHOS Catalyst by Cobley, Christopher J, Lennon, Ian C, Praquin, Céline, Zanotti-Gerosa, Antonio, Appell, Robert B, Goralski, Christian T, Sutterer, Angela C

“…An extremely efficient route to highly enantiomerically enriched 2-methylsuccinamic acid via asymmetric hydrogenation has been developed. By using…”
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