Search Results - "Cobianchi, Fabio"
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Structural and functional characterization of noncoding repetitive RNAs transcribed in stressed human cells
Published in Molecular biology of the cell (01-06-2005)“…Thermal and chemical stresses induce the formation in human cells of novel and transient nuclear structures called nuclear stress bodies (nSBs). These contain…”
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Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock
Published in Molecular biology of the cell (01-02-2004)“…Heat shock triggers the assembly of nuclear stress bodies that contain heat shock factor 1 and a subset of RNA processing factors. These structures are formed…”
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Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors
Published in Molecular biology of the cell (01-11-2001)“…Heterogeneous nuclear ribonucleoprotein (hnRNP) HAP (hnRNP A1 interacting protein) is a multifunctional protein with roles in RNA metabolism, transcription,…”
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Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies
Published in Molecular biology of the cell (01-06-2002)“…We previously reported the identification of a novel nuclear compartment detectable in heat-shocked HeLa cells that we termed stress-induced Src-activated…”
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A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock
Published in Journal of cell science (15-05-1999)“…A two-hybrid screening in yeast for proteins interacting with the human hnRNP A1, yielded a nuclear protein of 917 amino acids that we termed hnRNP A1…”
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hnRNP A1 Selectively Interacts Through its Gly-rich Domain with Different RNA-binding Proteins
Published in Journal of molecular biology (14-06-1996)“…Heterogeneous nuclear ribonucleoproteins (hnRNPs) are abundant nuclear polypeptides, most likely involved in different steps of pre-mRNA processing. Protein A1…”
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RNA recognition motif 2 directs the recruitment of SF2/ASF to nuclear stress bodies
Published in Nucleic acids research (2004)“…Heat shock induces the transcriptional activation of large heterochromatic regions of the human genome composed of arrays of satellite III DNA repeats. A…”
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Structural and Functional Characterization of Noncoding Repetitive RNAs Transcribed in Stressed Human CellsD
Published in Molecular biology of the cell (01-06-2005)“…Thermal and chemical stresses induce the formation in human cells of novel and transient nuclear structures called nuclear stress bodies (nSBs). These contain…”
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Heart-Specific Localization of Emerin: New Insights Into Emery-Dreifuss Muscular Dystrophy
Published in Human molecular genetics (01-12-1997)“…Emery-Dreifuss muscular dystrophy (EDMD) is an X-linked inherited disease characterized by early contracture of the elbows, Achilles tendons and post-cervical…”
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10
Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments
Published in Journal of cell science (01-11-2000)“…We have previously described HAP, a novel hnRNP protein that is identical both to SAF-B, a component of the nuclear scaffold, and to HET, a transcriptional…”
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11
Transcriptional Activation of a Constitutive Heterochromatic Domain of the Human Genome in Response to Heat ShockD
Published in Molecular biology of the cell (01-02-2004)“…Heat shock triggers the assembly of nuclear stress bodies that contain heat shock factor 1 and a subset of RNA processing factors. These structures are formed…”
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Phosphorylation of human hnRNP protein A1 abrogates in vitro strand annealing activity
Published in Nucleic acids research (25-02-1993)“…In HeLa cells metabolically labeled in vlvo wlth [32P] orthophosphate in the presence of okadalc acid the concentration of phosphorylated A1 proteln was…”
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Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly
Published in Nucleic acids research (11-10-1992)“…The in vitro interaction of recombinant hnRNP A1 with purified snRNPs and with pre-mRNAs was investigated. We show that protein A1 can stably bind U2 and U4…”
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Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides homologous to intron/exon acceptor sites
Published in Nucleic acids research (25-11-1990)“…The reported binding preference of human hnRNP protein A1 for the 3'-splice site of some introns (Swanson and Dreyfuss (1988) EMBO J. 7, 3519-3529; Mayrand and…”
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Human hnRNP protein A1 gene expression. Structural and functional characterization of the promoter
Published in Journal of molecular biology (05-03-1993)“…hnRNP protein A1 (34 kDa, pl 9.5) is a prominent member of the family of proteins (hnRNP proteins) that associate with the nascent transcripts of RNA…”
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Emerin presence in platelets
Published in Acta neuropathologica (01-09-2000)“…Emerin is an almost ubiquitous protein which is abnormal in X-linked Emery-Dreifuss muscular dystrophy (EMD), a syndrome characterized by muscle weakness,…”
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Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein
Published in The EMBO journal (01-04-1990)“…The human hnRNP core protein A1 (34 kd) is encoded by a 4.6 kb gene split into 10 exons. Here we show that the A1 gene can be differentially spliced by the…”
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Human hnRNP protein A1: a model polypeptide for a structural and genetic investigation of a broad family of RNA binding proteins
Published in Genetica (01-01-1994)“…The hnRNP fiber is the substrate on which pre-mRNA processing occurs. The protein moiety of the fiber (hnRNP proteins) constitutes a broad family of RNA…”
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Modeling by homology of RNA binding domain in A1 hnRNP protein
Published in FEBS letters (17-12-1990)“…Eukaryotic nuclear RNA binding proteins share a common sequence motif thought to be implicated in RNA binding. One of the two domains present in A1 hnRNP…”
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Antibodies to hnRNP core protein A1 in connective tissue diseases
Published in Journal of cellular biochemistry (01-05-1989)“…We investigated the specificity of circulating autoantibodies to a heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), obtained by recombinant DNA…”
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